ERI3 and YTHDF1

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		ERI3	YTHDF1
Description		ERI1 exoribonuclease family member 3	YTH N6-methyladenosine RNA binding protein F1
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GO Annotations	Cellular Component		P-body Cytoplasm Cytoplasmic Stress Granule
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Hydrolase Activity Metal Ion Binding	RNA Binding MRNA Binding Protein Binding Ribosome Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process		Immune System Process Regulation Of Antigen Processing And Presentation Learning Memory Stress Granule Assembly Regulation Of MRNA Stability Positive Regulation Of Translation Positive Regulation Of Translational Initiation MRNA Destabilization Organelle Assembly Regulation Of Long-term Synaptic Potentiation Regulation Of Axon Guidance
Pathways
Drugs
Diseases
GWAS		Anxiety ( 33859377) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444)	Response to cytadine analogues (cytosine arabinoside) ( 24483146)
Interacting Genes		6 interacting genes: CENPO CPEB2 FNDC3B PRNP SHANK3 YTHDF1	42 interacting genes: ABHD11 BATF2 BICD2 C6orf15 CFTR CLK2 CPSF7 CTTN DMRTB1 DYNC1I1 ERI3 FAM168A FHIT HEY1 HSF4 ITSN2 KRTAP13-1 KRTAP26-1 KRTAP7-1 KRTAP8-1 LASP1 MAGED1 MOV10 MSX2 OIP5 PPIL3 PRR32 PRRC2B QKI RBFOX2 RBM22 RBMS3 RBPMS SARNP SF1 SNCA SNRPA TLE5 TMED9 VPS37C XRN2 ZNF34
Entrez ID		79033	54915
HPRD ID		15175	11691
Ensembl ID		ENSG00000117419	ENSG00000149658
Uniprot IDs		B4DEX5 B4DN03 O43414	Q9BYJ9
PDB IDs		2XRI 7K05 7K06 7K07 7LPY 7LPZ 7LQ0	4RCI 4RCJ 7PCU 7QKN 7QL7 7YYE 7YYF 7YYJ 7YZ8 8BS4
Enriched GO Terms of Interacting Partners?		Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Glutamate Receptor Signaling Pathway Memory Regulation Of Synaptic Plasticity Dendritic Spine Organization Learning Or Memory Neuron Projection Organization Postsynapse Organization Cognition Type 8 Metabotropic Glutamate Receptor Binding Ribosome Binding Mis6-Sim4 Complex Negative Regulation Of Cytoplasmic Translational Elongation Modulation Of Chemical Synaptic Transmission Guanylate Kinase-associated Protein Clustering Cellular Component Assembly Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Postsynapse Organization Negative Regulation Of Dendritic Spine Maintenance Cupric Ion Binding Regulation Of Cell Projection Organization Type 5 Metabotropic Glutamate Receptor Binding FHF Complex Learning Centromere Complex Assembly Negative Regulation Of Cell Volume AMPA Glutamate Receptor Clustering Synaptic Receptor Adaptor Activity Positive Regulation Of Synapse Structural Plasticity NMDA Glutamate Receptor Clustering Striatal Medium Spiny Neuron Differentiation Negative Regulation Of Translational Elongation ATP-dependent Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Manchette Assembly Postsynaptic Density Assembly Regulation Of Synapse Structural Plasticity Protein Localization To Perinuclear Region Of Cytoplasm Vocal Learning Neuron Spine Cuprous Ion Binding Positive Regulation Of Long-term Neuronal Synaptic Plasticity Observational Learning Negative Regulation Of Cytoplasmic Translation Postsynaptic Density Microtubule Binding Dendritic Spine Maintenance Nervous System Process Postsynaptic Specialization Assembly	Nucleic Acid Binding MRNA Processing RNA Binding Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome MRNA Metabolic Process Negative Regulation Of Biosynthetic Process RNA Processing RNA Splicing, Via Transesterification Reactions RNA Splicing MRNA Binding
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