ACY3 and PMM2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ACY3	PMM2
Description		aminoacylase 3	phosphomannomutase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Cilium Microtubule Cytoskeleton Neuronal Cell Body
	Molecular Function	Aminoacylase Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Ester Bonds Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Identical Protein Binding Metal Ion Binding	Phosphomannomutase Activity Protein Binding Isomerase Activity Metal Ion Binding
	Biological Process		Mannose Metabolic Process Protein Glycosylation Protein N-linked Glycosylation GDP-mannose Biosynthetic Process GDP-mannose Biosynthetic Process From Mannose GDP-D-mannose Biosynthetic Process From Fructose-6-phosphate
Pathways		Aflatoxin activation and detoxification	Defective PMM2 causes PMM2-CDG Synthesis of GDP-mannose
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Serum metabolite concentrations in chronic kidney disease ( 33838163) Serum metabolite levels ( 24625756 33031748) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolite modules (eigenmetabolites) in chronic kidney disease ( 31959995) Waist circumference adjusted for body mass index ( 34021172)	Glaucoma (high intraocular pressure) ( 25173107)
Interacting Genes		21 interacting genes: AAMDC ARF5 ASPA CYSRT1 DDIT4L GORASP2 INCA1 KRTAP10-3 KRTAP10-8 KRTAP15-1 KRTAP26-1 LNX1 MAP3K8 NEDD4L NOTCH2NLA PIAS2 PLEKHF2 PMM2 PTGER4 RARG RRAS	3 interacting genes: ACY3 MEOX2 SGK2
Entrez ID		91703	5373
HPRD ID		12422	03472
Ensembl ID		ENSG00000132744	ENSG00000140650
Uniprot IDs		E9PRA7 Q96HD9	A0A0S2Z4J6 O15305 Q59F02
PDB IDs			2AMY 2Q4R 7O0C 7O1B 7O4G 7O58 7O5Z
Enriched GO Terms of Interacting Partners?		Intermediate Filament
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