MTNR1B and FTL

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (two hybrid)

		MTNR1B	FTL
Description		melatonin receptor 1B	ferritin light chain
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GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse	Extracellular Region Cytoplasm Lysosome Autophagosome Cytosol Membrane Cytoplasmic Vesicle Azurophil Granule Lumen Autolysosome Extracellular Exosome Ferritin Complex
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity	Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Negative Regulation Of CGMP-mediated Signaling Glucose Homeostasis Positive Regulation Of Circadian Rhythm Camera-type Eye Development Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Vasoconstriction Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Neuronal Action Potential	Iron Ion Transport Intracellular Iron Ion Homeostasis
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon Tepotinib	Iron Dextran Protoporphyrin Ferric pyrophosphate Sodium ferric gluconate complex Ferric pyrophosphate citrate
Diseases		Type II diabetes mellitus	Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia
GWAS		Acute insulin response ( 28490609) Adverse response to radiation therapy ( 23719583) Birth weight ( 27680694 31043758) Chronotype ( 30696823) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Daytime nap ( 33568662) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Diabetes (gestational) ( 22233651) Fasting blood glucose ( 33842983 22581228 20081858 29844224 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting plasma glucose ( 25187374 22508271 19651812 19060907 19060909) Glucose homeostasis traits ( 25524916) Glycated hemoglobin levels ( 28898252 34059833 20858683) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Glycemic traits (pregnancy) ( 23903356) Hemoglobin A1c levels ( 29403010) High fasting blood glucose ( 31910446) Homeostasis model assessment of beta-cell function ( 20081858) Incremental insulin ( 24699409) Insomnia (caffeine-induced) ( 22754043) Insulin disposition index ( 24699409 28490609) Insulin levels ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin secretion rate ( 28490609) Insulin-related traits (multivariate analysis) ( 32002517) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 22286219 21909109) Obesity-related traits ( 23251661) Offspring birth weight ( 29309628 31043758) Peak insulin response ( 28490609) Pulse pressure ( 30224653 30578418) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Type 2 diabetes ( 24509480 22885922 20581827 28254843 32499647 28869590 29358691 30297969 30054458) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658)
Interacting Genes		133 interacting genes: ACKR1 ACTN1 ADCY3 ANXA6 AP1B1 AP4E1 APOL6 ARHGAP1 ARHGAP28 ATP6V0B BCL2L1 BCL2L13 BTBD1 CANX CD99 CDC16 CDH11 CDH13 CDH4 CLASP1 CLDND1 COG4 COG8 COPA COX11 CRELD1 CSE1L CTNNA1 CTNND1 CUL3 DISP3 DMXL2 DST DYNC1H1 DYNC2H1 EBF1 EBP EIF3A ERG28 ESPL1 EVA1A FANCI FLNA FSTL1 FTL GGT7 GNAI1 GNAI2 GNAI3 GNAS GNB1 GNB2 GNB4 GPM6B GPR50 HARS1 HECTD1 HNRNPA0 HSPA5 INTS1 IPO4 IPO9 IRF2BP2 IRS4 ITM2C ITPR3 KMT2C LTBR MACF1 MARCHF6 MARF1 MFF MIA3 MMP2 MON2 MTMR6 MTNR1A OTX1 PCDHB10 PCNX4 PDIA3 PDIA6 PEAK1 PI4KA PIDD1 POLI PPM1G PPP1R21 PPP6R1 PRKDC PSMD8 PSME3IP1 PTPRD RECK RIPOR2 RNF185 RNF40 RNF41 RPRD2 SDHD SF3A3 SLC12A4 SLC2A3 SLC30A1 SLC39A6 SLC3A2 SLC4A7 SMARCD1 SMC3 SREBF1 SREBF2 STMN4 SYNE2 TANGO6 TBCD THOC1 THRA TINF2 TLN1 TMEM14A TMEM230 TRIM24 TRIM46 TRIP12 UBAP2L UBQLN2 UBQLN4 UBR4 USP34 VPS35 XBP1 YWHAB YWHAQ	31 interacting genes: ACO1 CLEC4G FTH1 GADD45A GLP1R GRB2 HTT IGDCC3 KNG1 KPNA3 MAP3K12 MEOX2 MPHOSPH6 MTNR1B MYOC MYOG NTAQ1 PALS2 PIK3CA PPP1CC PTN RAP2A SDCBP SLC13A1 SMAD9 SPINK7 TAF10 UBC USHBP1 VKORC1 ZDHHC17
Entrez ID		4544	2512
HPRD ID		02882	00616
Ensembl ID		ENSG00000134640	ENSG00000087086
Uniprot IDs		P49286	A0A384MDR3 P02792
PDB IDs		6ME6 6ME7 6ME8 6ME9 7VH0	2FFX 2FG4 2FG8 3KXU 4V6B 5LG8 6TR9 6TS0 6TS1 6TSA 6TSF 6TSJ 6WX6
Enriched GO Terms of Interacting Partners?		Membrane Heterotrimeric G-protein Complex Focal Adhesion Cadherin Binding Extracellular Exosome Catenin Complex Lysosomal Membrane Guanyl Nucleotide Binding Homotypic Cell-cell Adhesion Cell-substrate Junction Assembly Regulation Of Organelle Organization Cell-substrate Junction Organization Establishment Of Protein Localization G-protein Beta/gamma-subunit Complex Binding Platelet Aggregation Cell Junction Assembly Biological_process C-8 Sterol Isomerase Activity Vinculin Binding Intracellular Protein Localization Protein Transport ERAD Pathway Protein Folding In Endoplasmic Reticulum Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Regulation Of Cholesterol Biosynthetic Process Cytoplasmic Vesicle Regulation Of Cellular Component Organization Protein Binding Cellular Response To Fluid Shear Stress Negative Regulation Of Transport Cell-cell Adhesion Melanosome Regulation Of Macroautophagy Regulation Of Autophagy Endoplasmic Reticulum Membrane ER-nucleus Signaling Pathway Ubiquitin-protein Transferase Activity Regulation Of Focal Adhesion Assembly Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell-cell Adhesion Mediated By Cadherin Anchoring Junction Synapse Intracellular Transport Negative Regulation Of Protein Localization Proteolysis Regulation Of Cell-substrate Adhesion Adenylate Cyclase Regulator Activity Response To Fluid Shear Stress
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