MTNR1B and TMEM230

Number of citations of the paper that reports this interaction (PubMedID 26514267)
0

Data Source:
BioGRID (two hybrid)

		MTNR1B	TMEM230
Description		melatonin receptor 1B	transmembrane protein 230
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Synapse	Endosome Early Endosome Late Endosome Autophagosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Synaptic Vesicle Endomembrane System Membrane Axon Cytoplasmic Vesicle Synapse Recycling Endosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity	Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Negative Regulation Of CGMP-mediated Signaling Glucose Homeostasis Positive Regulation Of Circadian Rhythm Camera-type Eye Development Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Vasoconstriction Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Transmission Of Nerve Impulse Positive Regulation Of Transmission Of Nerve Impulse Regulation Of Neuronal Action Potential	Synaptic Vesicle Transport Axonal Transport
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon Tepotinib
Diseases		Type II diabetes mellitus
GWAS		Acute insulin response ( 28490609) Adverse response to radiation therapy ( 23719583) Birth weight ( 27680694 31043758) Chronotype ( 30696823) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Daytime nap ( 33568662) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Diabetes (gestational) ( 22233651) Fasting blood glucose ( 33842983 22581228 20081858 29844224 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 34059833) Fasting plasma glucose ( 25187374 22508271 19651812 19060907 19060909) Glucose homeostasis traits ( 25524916) Glycated hemoglobin levels ( 28898252 34059833 20858683) Glycemic traits ( 23575436) Glycemic traits (pleiotropy) ( 31021400) Glycemic traits (pregnancy) ( 23903356) Hemoglobin A1c levels ( 29403010) High fasting blood glucose ( 31910446) Homeostasis model assessment of beta-cell function ( 20081858) Incremental insulin ( 24699409) Insomnia (caffeine-induced) ( 22754043) Insulin disposition index ( 24699409 28490609) Insulin levels ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin secretion rate ( 28490609) Insulin-related traits (multivariate analysis) ( 32002517) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 22286219 21909109) Obesity-related traits ( 23251661) Offspring birth weight ( 29309628 31043758) Peak insulin response ( 28490609) Pulse pressure ( 30224653 30578418) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Type 2 diabetes ( 24509480 22885922 20581827 28254843 32499647 28869590 29358691 30297969 30054458) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658)
Interacting Genes		133 interacting genes: ACKR1 ACTN1 ADCY3 ANXA6 AP1B1 AP4E1 APOL6 ARHGAP1 ARHGAP28 ATP6V0B BCL2L1 BCL2L13 BTBD1 CANX CD99 CDC16 CDH11 CDH13 CDH4 CLASP1 CLDND1 COG4 COG8 COPA COX11 CRELD1 CSE1L CTNNA1 CTNND1 CUL3 DISP3 DMXL2 DST DYNC1H1 DYNC2H1 EBF1 EBP EIF3A ERG28 ESPL1 EVA1A FANCI FLNA FSTL1 FTL GGT7 GNAI1 GNAI2 GNAI3 GNAS GNB1 GNB2 GNB4 GPM6B GPR50 HARS1 HECTD1 HNRNPA0 HSPA5 INTS1 IPO4 IPO9 IRF2BP2 IRS4 ITM2C ITPR3 KMT2C LTBR MACF1 MARCHF6 MARF1 MFF MIA3 MMP2 MON2 MTMR6 MTNR1A OTX1 PCDHB10 PCNX4 PDIA3 PDIA6 PEAK1 PI4KA PIDD1 POLI PPM1G PPP1R21 PPP6R1 PRKDC PSMD8 PSME3IP1 PTPRD RECK RIPOR2 RNF185 RNF40 RNF41 RPRD2 SDHD SF3A3 SLC12A4 SLC2A3 SLC30A1 SLC39A6 SLC3A2 SLC4A7 SMARCD1 SMC3 SREBF1 SREBF2 STMN4 SYNE2 TANGO6 TBCD THOC1 THRA TINF2 TLN1 TMEM14A TMEM230 TRIM24 TRIM46 TRIP12 UBAP2L UBQLN2 UBQLN4 UBR4 USP34 VPS35 XBP1 YWHAB YWHAQ	14 interacting genes: AQP2 ARL4D CREB3 ERBB2 ERBB3 ERBB4 HTR4 LMNA MTNR1A MTNR1B RPL28 SGTA TMEM9 VKORC1
Entrez ID		4544	29058
HPRD ID		02882	12762
Ensembl ID		ENSG00000134640	ENSG00000089063
Uniprot IDs		P49286	A0A087WTT2 Q96A57
PDB IDs		6ME6 6ME7 6ME8 6ME9 7VH0
Enriched GO Terms of Interacting Partners?		Membrane Heterotrimeric G-protein Complex Focal Adhesion Cadherin Binding Extracellular Exosome Catenin Complex Lysosomal Membrane Guanyl Nucleotide Binding Homotypic Cell-cell Adhesion Cell-substrate Junction Assembly Regulation Of Organelle Organization Cell-substrate Junction Organization Establishment Of Protein Localization G-protein Beta/gamma-subunit Complex Binding Platelet Aggregation Cell Junction Assembly Biological_process C-8 Sterol Isomerase Activity Vinculin Binding Intracellular Protein Localization Protein Transport ERAD Pathway Protein Folding In Endoplasmic Reticulum Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Catabolic Process Regulation Of Cholesterol Biosynthetic Process Cytoplasmic Vesicle Regulation Of Cellular Component Organization Protein Binding Cellular Response To Fluid Shear Stress Negative Regulation Of Transport Cell-cell Adhesion Melanosome Regulation Of Macroautophagy Regulation Of Autophagy Endoplasmic Reticulum Membrane ER-nucleus Signaling Pathway Ubiquitin-protein Transferase Activity Regulation Of Focal Adhesion Assembly Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell-cell Adhesion Mediated By Cadherin Anchoring Junction Synapse Intracellular Transport Negative Regulation Of Protein Localization Proteolysis Regulation Of Cell-substrate Adhesion Adenylate Cyclase Regulator Activity Response To Fluid Shear Stress	ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Neuregulin Receptor Activity Melatonin Receptor Activity ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Receptor Complex Basal Plasma Membrane Protein-containing Complex Localization ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Basolateral Plasma Membrane ERBB Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Membrane Regulation Of Body Fluid Levels Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Protein Tyrosine Kinase Activity Peripheral Nervous System Development Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Regulation Of Biological Quality Growth Factor Binding Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Epithelial Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Activity Localization Within Membrane Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Animal Organ Development Establishment Of Planar Polarity Involved In Nephron Morphogenesis Large Intestinal Transit Negative Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Deacetylase Activity Vitamin-K-epoxide Reductase (warfarin-insensitive) Activity Protein Localization To Synapse Heart Development Glial Cell Development Lumenal Side Of Membrane Glycerol Transmembrane Transporter Activity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Cardiac Muscle Tissue Development
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