MTNR1B and PDIA6

Number of citations of the paper that reports this interaction (PMID 17215244)
14

Data Source:
HPRD (in vivo)

		MTNR1B	PDIA6
Gene Name		melatonin receptor 1B	protein disulfide isomerase family A, member 6
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Melanosome Extracellular Vesicular Exosome
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Melatonin Receptor Activity	Protein Disulfide Isomerase Activity Protein Binding
	Biological Process	G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission Glucose Homeostasis Regulation Of Insulin Secretion	Protein Folding Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Endoplasmic Reticulum Unfolded Protein Response Response To Endoplasmic Reticulum Stress Apoptotic Cell Clearance Cellular Protein Metabolic Process Cell Redox Homeostasis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding	IRE1alpha activates chaperones XBP1(S) activates chaperone genes Unfolded Protein Response (UPR)
Drugs		Ramelteon Melatonin Agomelatine
Diseases
GWAS		Adverse response to radiation therapy ( 23719583) Diabetes (gestational) ( 22233651) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) Fasting plasma glucose ( 19060907 19060909 19651812 22508271) Glycated hemoglobin levels ( 20858683) Glycemic traits ( 23575436) Insomnia (caffeine-induced) ( 22754043) Metabolic syndrome ( 22399527) Metabolic traits ( 19060910) Metabolite levels ( 21909109 22286219) Obesity-related traits ( 23251661) Type 2 diabetes ( 20581827)
Protein-Protein Interactions		20 interactors: CANX COPA CTNND1 FLNA GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 HNRNPA0 HSPA5 IRS4 ITM2C MTNR1A PDIA6 PI4KA PPM1G VPS35 YWHAQ	9 interactors: ATP13A2 CASP8 CLN8 CSNK2A1 MTNR1A MTNR1B SLC2A4 SUMO4 VKORC1
Entrez ID		4544	10130
HPRD ID		02882	07504
Ensembl ID		ENSG00000134640	ENSG00000143870
Uniprot IDs		P49286	Q15084
PDB IDs			1X5D 3VWW 3W8J 4EF0 4GWR
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Signaling Cell Communication Substantia Nigra Development Signal Transduction Wound Healing Vesicle-mediated Transport Neural Nucleus Development Cell Activation Response To Wounding G-protein Coupled Receptor Signaling Pathway Midbrain Development G-protein Coupled Acetylcholine Receptor Signaling Pathway Cell-cell Signaling Cellular Response To Stimulus Synaptic Transmission Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Response To Stimulus Negative Regulation Of CAMP Biosynthetic Process Negative Regulation Of CAMP Metabolic Process Dopamine Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Peptide Hormone Cellular Response To Glucagon Stimulus Negative Regulation Of Nucleotide Metabolic Process Membrane Organization Response To Peptide Vesicle Organization Vesicle Fusion Regulation Of Protein Folding In Endoplasmic Reticulum Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Response To Glucagon Positive Regulation Of Nuclease Activity Regulation Of Adenylate Cyclase Activity Regulation Of Signal Transduction Regulation Of Cellular Process Regulation Of Cyclase Activity Platelet Degranulation Secretion Cerebellum Structural Organization Negative Regulation Of Late Endosome To Lysosome Transport Organelle Fusion Cellular Response To Peptide Hormone Stimulus	Amylopectin Biosynthetic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development L-glutamate Uptake Involved In Synaptic Transmission TRAIL-activated Apoptotic Signaling Pathway Response To Ethanol Response To Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Tagcloud ?		china cnki database electronic embase employed estimate gdm genetic gestational inclusion inconclusive infrastructure irs1 medline melatonin mellitus polymorphisms pubmed risks rs10830963 rs1387153 rs1801278 searched ten value variant variants	brains contributions cpg dysregulation epigenome excessive gpr3 h3k4me3 hairy hd hes4 htt huntington hypermethylation jagged2 lastly mapping mark mash1 methylated modifying neurodegeneration prefrontal shrna split striatal strikingly tmem106b trimethyl
Tagcloud (Difference) ?		china cnki database electronic embase employed estimate gdm genetic gestational inclusion inconclusive infrastructure irs1 medline melatonin mellitus polymorphisms pubmed risks rs10830963 rs1387153 rs1801278 searched ten value variant variants	brains contributions cpg dysregulation epigenome excessive gpr3 h3k4me3 hairy hd hes4 htt huntington hypermethylation jagged2 lastly mapping mark mash1 methylated modifying neurodegeneration prefrontal shrna split striatal strikingly tmem106b trimethyl
Tagcloud (Intersection) ?