ATOX1 and CFAP410

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		ATOX1	CFAP410
Name		antioxidant 1 copper chaperone	cilia and flagella associated protein 410
Structure
GO Annotations	Cellular Component	Cytosol	Photoreceptor Outer Segment Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Photoreceptor Connecting Cilium Ciliary Basal Body Cell Projection Photoreceptor Cell Cilium
	Molecular Function	Copper Ion Binding Protein Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding Metal Ion Binding ATPase Binding Cuprous Ion Binding	Protein Binding
	Biological Process	Monoatomic Ion Transport Copper Ion Transport Intracellular Copper Ion Homeostasis Response To Oxidative Stress Negative Regulation Of Apoptotic Process Copper Ion Export	DNA Damage Response Cytoskeleton Organization Smoothened Signaling Pathway Regulation Of Cell Shape Cell Projection Organization Cilium Assembly
Pathways		Detoxification of Reactive Oxygen Species Ion influx/efflux at host-pathogen interface	None
Drugs		Cisplatin Sucrose Benzamidine	None
GWAS		Creatinine levels ( 29403010 ) Glomerular filtration rate ( 29403010 ) Red cell distribution width ( 32888494 ) Systolic blood pressure change trajectory ( 27980656 )	No GWAS studies recorded
Novel Interactors		None recorded	2 novel interactors: COL6A1 DOP1B
Interacting Genes		9 interacting genes: ATP7A ATP7B CFAP410 COMP FAM118A FKBP4 GGPS1 NECAB1 TRAF4	4 interacting genes: ATOX1 FBXO3 GMCL1 SPG21
Entrez ID		475	755
HPRD ID		03779	04427
Ensembl ID		ENSG00000177556	ENSG00000160226
Uniprot IDs		O00244	O43822
PDB IDs		1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX 4QOT 4YDX 4YEA 5F0W 5T7L 7DC1 7ZC3	8AXR
GO Terms Enriched among Interactors		Copper Ion Transport P-type Divalent Copper Transporter Activity P-type Monovalent Copper Transporter Activity Copper-dependent Protein Binding Copper Ion Export Copper Ion Import Copper Ion Transmembrane Transporter Activity Copper Ion Transmembrane Transport ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Perinuclear Region Of Cytoplasm Intracellular Copper Ion Homeostasis Copper Ion Homeostasis Copper Ion Binding Skin Development Collagen Fibril Organization Steroid Hormone Receptor Complex Assembly Geranylgeranyl Diphosphate Biosynthetic Process Prenyl Diphosphate Synthase Activity Geranylgeranyl Diphosphate Synthase Activity Geranyl Diphosphate Biosynthetic Process (2E,6E)-farnesyl Diphosphate Synthase Activity Dimethylallyltranstransferase Activity Cartilage Development Trans-Golgi Network Membrane Superoxide Dismutase Copper Chaperone Activity Geranyl Diphosphate Metabolic Process P-type Ion Transporter Activity Epinephrine Metabolic Process Tendon Development Cartilage Homeostasis Male Sex Differentiation Farnesyl Diphosphate Biosynthetic Process Negative Regulation Of Catecholamine Metabolic Process Sequestering Of Calcium Ion Late Endosome Metal Ion Transport Farnesyl Diphosphate Metabolic Process Pyramidal Neuron Development Viral Translational Frameshifting	None