ATOX1 and ATP7B

Number of citations of the paper that reports this interaction (PMID 10557326)
47

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		ATOX1	ATP7B
Gene Name		antioxidant 1 copper chaperone	ATPase, Cu++ transporting, beta polypeptide
Image
Gene Ontology Annotations	Cellular Component	Cytosol	Golgi Membrane Mitochondrion Late Endosome Trans-Golgi Network Integral Component Of Plasma Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Basolateral Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Copper Ion Transmembrane Transporter Activity Copper Ion Binding Metallochaperone Activity Copper Chaperone Activity Copper-dependent Protein Binding	Copper-exporting ATPase Activity Copper Ion Binding Protein Binding ATP Binding
	Biological Process	Response To Reactive Oxygen Species Copper Ion Transport Cellular Copper Ion Homeostasis Response To Oxidative Stress Intracellular Copper Ion Transport Copper Ion Transmembrane Transport	Copper Ion Transport Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Lactation Metabolic Process Copper Ion Import Intracellular Copper Ion Transport Ion Transmembrane Transport Response To Copper Ion Sequestering Of Calcium Ion Transmembrane Transport Copper Ion Export
Pathways		Detoxification of Reactive Oxygen Species	Ion transport by P-type ATPases Ion channel transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: ATP7A ATP7B C21orf2 FAM118A FKBP4 GGPS1	4 interactors: ATOX1 DCTN4 HP ZBTB16
Entrez ID		475	540
HPRD ID		03779	06050
Ensembl ID		ENSG00000177556	ENSG00000123191
Uniprot IDs		O00244	B7ZLR4 E7ET55 F5H562 F5H748 P35670
PDB IDs		1FE0 1FE4 1FEE 1TL4 1TL5 2K1R 2LQ9 3CJK 3IWL 3IWX	2ARF 2EW9 2KOY 2LQB 2ROP
Enriched GO Terms of Interacting Partners?		Copper Ion Transport Copper Ion Export Copper Ion Transmembrane Transport Copper Ion Import Cellular Copper Ion Homeostasis Copper Ion Homeostasis Response To Copper Ion Lactation Gland Development Body Fluid Secretion Elastin Biosynthetic Process Steroid Hormone Receptor Complex Assembly Plasma Membrane Copper Ion Transport Geranylgeranyl Diphosphate Biosynthetic Process Transition Metal Ion Homeostasis Geranyl Diphosphate Biosynthetic Process Farnesyl Diphosphate Biosynthetic Process Metal Ion Transport Mammary Gland Development Elastin Metabolic Process Detoxification Of Copper Ion Response To Iron(III) Ion Sequestering Of Calcium Ion Epinephrine Metabolic Process Intracellular Copper Ion Transport Farnesyl Diphosphate Metabolic Process Cation Transport Norepinephrine Biosynthetic Process Negative Regulation Of Metalloenzyme Activity Elastic Fiber Assembly Positive Regulation Of Metalloenzyme Activity Response To Metal Ion Regulation Of Oxidative Phosphorylation Sequestering Of Metal Ion Tyrosine Metabolic Process Pyramidal Neuron Development Pyramidal Neuron Differentiation Norepinephrine Metabolic Process Cellular Metal Ion Homeostasis Negative Regulation Of Microtubule Polymerization Cellular Zinc Ion Homeostasis Cerebellar Purkinje Cell Differentiation Serotonin Metabolic Process Cellular Cation Homeostasis Extracellular Matrix Assembly Cellular Ion Homeostasis Zinc Ion Homeostasis Cerebellar Purkinje Cell Layer Morphogenesis Ion Transport Metal Ion Homeostasis	Negative Regulation Of Hydrogen Peroxide Catabolic Process Response To Reactive Oxygen Species Intracellular Copper Ion Transport Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of NK T Cell Differentiation Male Germ-line Stem Cell Asymmetric Division Regulation Of Hydrogen Peroxide Metabolic Process Copper Ion Transmembrane Transport Response To Oxidative Stress Nuclear Migration Immune System Process Cellular Copper Ion Homeostasis Copper Ion Homeostasis Cellular Localization Positive Regulation Of Cell Death Negative Regulation Of Oxidoreductase Activity Establishment Of Nucleus Localization Copper Ion Transport Regulation Of Response To Reactive Oxygen Species Positive Regulation Of Chondrocyte Differentiation
Tagcloud ?		accumulated affects allowing chains chaperones chelated cisplatin compartments copper cu decays elucidation embryonic emission exist fibroblast hct nuclei nucleus optimizing owing positron radionuclide radiopharmaceuticals tomography traffic transport transporting upregulating	abcb1 abcg2 arg72pro arg952lys asp1853asn atm backgroundovarian chances conclusionsthe emphasized facts gstm1 gstp1 gstt1 ile1145 inverted mark mark0 markabcb1 methodsin pgr question resultsten ser406ala ser894ala underscore unfavorable val660leu xenobiotics
Tagcloud (Difference) ?		accumulated affects allowing chains chaperones chelated cisplatin compartments copper cu decays elucidation embryonic emission exist fibroblast hct nuclei nucleus optimizing owing positron radionuclide radiopharmaceuticals tomography traffic transport transporting upregulating	abcb1 abcg2 arg72pro arg952lys asp1853asn atm backgroundovarian chances conclusionsthe emphasized facts gstm1 gstp1 gstt1 ile1145 inverted mark mark0 markabcb1 methodsin pgr question resultsten ser406ala ser894ala underscore unfavorable val660leu xenobiotics
Tagcloud (Intersection) ?