ACVR1C and INHBB

Number of citations of the paper that reports this interaction (PMID 15196700)
20

Data Source:
HPRD (in vitro)

		ACVR1C	INHBB
Gene Name		activin A receptor, type IC	inhibin, beta B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Activin Receptor Complex	Extracellular Region Extracellular Space Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity ATP Binding Activin Receptor Activity, Type I Growth Factor Binding Nodal Binding Metal Ion Binding	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Hormone Activity Protein Binding Growth Factor Activity Protein Homodimerization Activity Host Cell Surface Receptor Binding
	Biological Process	Response To Dietary Excess Protein Phosphorylation Response To Glucose Lipid Storage Signal Transduction By Phosphorylation Cell Differentiation Apoptotic Nuclear Changes Response To Insulin Nodal Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Insulin Secretion Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation	Ovarian Follicle Development Defense Response Cellular Response To Starvation Response To Mechanical Stimulus Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Cell Differentiation Cellular Response To Insulin Stimulus Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Cellular Response To Leptin Stimulus Fat Cell Differentiation Negative Regulation Of Insulin Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Hepatocyte Growth Factor Biosynthetic Process Cell Development Oocyte Development Positive Regulation Of Ovulation SMAD Protein Signal Transduction Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Signaling by Activin Regulation of signaling by NODAL Signaling by NODAL	Antagonism of Activin by Follistatin Peptide hormone metabolism Glycoprotein hormones Signaling by Activin Peptide hormone biosynthesis
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Breast size ( 22747683) Obesity ( 21552555) Urate levels ( 23263486)
Protein-Protein Interactions		2 interactors: INHBB TDGF1	10 interactors: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B FNTA IGSF1 INHA INHBA INHBC
Entrez ID		130399	3625
HPRD ID		10608	00934
Ensembl ID		ENSG00000123612	ENSG00000163083
Uniprot IDs		Q8NER5	P09529
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Hepatocyte Growth Factor Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Gonadotropin Secretion Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Cellular Response To Leptin Stimulus Response To Leptin Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Anterior/posterior Axis Specification, Embryo Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Interleukin-6 Positive Regulation Of Cellular Protein Metabolic Process Response To Epidermal Growth Factor Negative Regulation Of Signaling Activin Receptor Signaling Pathway Response To Interleukin-6 Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Negative Regulation Of Cytokine Biosynthetic Process Defense Response Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Oocyte Development Regulation Of Apoptotic Process Oocyte Differentiation Regulation Of Phosphorus Metabolic Process Embryonic Axis Specification Regulation Of Cell Death Positive Regulation Of Cell-matrix Adhesion Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Hormone Secretion Positive Regulation Of Fibroblast Proliferation Regulation Of Intracellular Signal Transduction Anterior/posterior Axis Specification Somatic Stem Cell Maintenance	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Mesoderm Development Signal Transduction Regulation Of Phosphorus Metabolic Process Regulation Of Erythrocyte Differentiation Positive Regulation Of Bone Mineralization Regulation Of Myeloid Cell Differentiation Signaling Positive Regulation Of Biomineral Tissue Development Cell Communication Gastrulation Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Gastrulation With Mouth Forming Second Regulation Of Signal Transduction Regulation Of Follicle-stimulating Hormone Secretion SMAD Protein Signal Transduction Development Of Primary Sexual Characteristics Negative Regulation Of Hormone Secretion Hemoglobin Biosynthetic Process Cellular Response To Stimulus Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Gonadotropin Secretion Positive Regulation Of Myeloid Cell Differentiation BMP Signaling Pathway Sex Differentiation Negative Regulation Of B Cell Differentiation
Tagcloud ?			actb activin activins canonical canonically comprise concert cord cords incompletely ligands maturation maturing morphogenetic myelin myelination numbers oligodendrocyte oligodendrocytes olp olps persistently recover smad3 smads specified spinal tgfbeta tgfbeta1
Tagcloud (Difference) ?			actb activin activins canonical canonically comprise concert cord cords incompletely ligands maturation maturing morphogenetic myelin myelination numbers oligodendrocyte oligodendrocytes olp olps persistently recover smad3 smads specified spinal tgfbeta tgfbeta1
Tagcloud (Intersection) ?