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ACVR1C and TDGF1
Number of citations of the paper that reports this interaction (PMID
11485994
)
60
Data Source:
HPRD
(in vivo)
ACVR1C
TDGF1
Gene Name
activin A receptor, type IC
teratocarcinoma-derived growth factor 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Activin Receptor Complex
Extracellular Space
Nucleus
Golgi Apparatus
Plasma Membrane
Cell Surface
Apical Plasma Membrane
Extrinsic Component Of Plasma Membrane
Anchored Component Of Membrane
Membrane Raft
Perinuclear Region Of Cytoplasm
Molecular Function
Receptor Signaling Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
ATP Binding
Activin Receptor Activity, Type I
Growth Factor Binding
Nodal Binding
Metal Ion Binding
Receptor Binding
Protein Binding
Growth Factor Activity
Biological Process
Response To Dietary Excess
Protein Phosphorylation
Response To Glucose
Lipid Storage
Signal Transduction By Phosphorylation
Cell Differentiation
Apoptotic Nuclear Changes
Response To Insulin
Nodal Signaling Pathway
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Negative Regulation Of Insulin Secretion
Negative Regulation Of Trophoblast Cell Migration
Negative Regulation Of Chorionic Trophoblast Cell Proliferation
Activation Of MAPK Activity
Vasculogenesis
In Utero Embryonic Development
Morphogenesis Of A Branching Structure
Positive Regulation Of Cell-matrix Adhesion
Cell Migration Involved In Sprouting Angiogenesis
Epidermal Growth Factor Receptor Signaling Pathway
Gastrulation
Heart Development
Positive Regulation Of Cell Proliferation
Anterior/posterior Axis Specification, Embryo
Embryo Development
Regulation Of Signal Transduction
Positive Regulation Of Endothelial Cell Migration
Peptidyl-serine Phosphorylation
Cell Differentiation
Positive Regulation Of Cell Migration
BMP Signaling Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Mammary Gland Development
Somatic Stem Cell Maintenance
Cellular Response To Hepatocyte Growth Factor Stimulus
Negative Regulation Of Apoptotic Process
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Cardiac Muscle Cell Differentiation
Canonical Wnt Signaling Pathway
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-6
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Pathways
Signaling by Activin
Regulation of signaling by NODAL
Signaling by NODAL
Transcriptional regulation of pluripotent stem cells
Regulation of signaling by NODAL
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Signaling by NODAL
Drugs
Diseases
GWAS
Protein-Protein Interactions
2 interactors:
INHBB
TDGF1
10 interactors:
ACVR1B
ACVR1C
ANG
AP2S1
BAG6
COPS6
FARSA
FBLN1
GDF9
LRIF1
Entrez ID
130399
6997
HPRD ID
10608
01757
Ensembl ID
ENSG00000123612
ENSG00000241186
Uniprot IDs
Q8NER5
F5H1T8
P13385
PDB IDs
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Hepatocyte Growth Factor Biosynthetic Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Follicle-stimulating Hormone Secretion
Positive Regulation Of Follicle-stimulating Hormone Secretion
Positive Regulation Of Ovulation
Regulation Of Follicle-stimulating Hormone Secretion
Negative Regulation Of Gonadotropin Secretion
Cellular Response To Hepatocyte Growth Factor Stimulus
Regulation Of MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Cellular Response To Leptin Stimulus
Response To Leptin
Positive Regulation Of Phosphorylation
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Protein Modification Process
Anterior/posterior Axis Specification, Embryo
Cell Migration Involved In Sprouting Angiogenesis
Regulation Of Protein Phosphorylation
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Interleukin-6
Positive Regulation Of Cellular Protein Metabolic Process
Response To Epidermal Growth Factor
Negative Regulation Of Signaling
Activin Receptor Signaling Pathway
Response To Interleukin-6
Blood Vessel Endothelial Cell Migration
Positive Regulation Of Protein Metabolic Process
Positive Regulation Of Signal Transduction
Regulation Of Phosphorylation
Negative Regulation Of Cytokine Biosynthetic Process
Defense Response
Negative Regulation Of Insulin Secretion
Negative Regulation Of Peptide Secretion
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Oocyte Development
Regulation Of Apoptotic Process
Oocyte Differentiation
Regulation Of Phosphorus Metabolic Process
Embryonic Axis Specification
Regulation Of Cell Death
Positive Regulation Of Cell-matrix Adhesion
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
SMAD Protein Signal Transduction
Sprouting Angiogenesis
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Hormone Secretion
Positive Regulation Of Fibroblast Proliferation
Regulation Of Intracellular Signal Transduction
Anterior/posterior Axis Specification
Somatic Stem Cell Maintenance
Nodal Signaling Pathway
Positive Regulation Of Cellular Protein Metabolic Process
Regulation Of Cellular Protein Metabolic Process
Activin Receptor Signaling Pathway
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Metabolic Process
Reproductive Process
Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Oocyte Development
Oocyte Differentiation
Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Enzyme Linked Receptor Protein Signaling Pathway
Oogenesis
Negative Regulation Of Chorionic Trophoblast Cell Proliferation
Positive Regulation Of Trophoblast Cell Migration
Oocyte Growth
Female Gamete Generation
Single Organism Reproductive Process
Development Of Primary Female Sexual Characteristics
Regulation Of Chorionic Trophoblast Cell Proliferation
Negative Regulation Of Trophoblast Cell Migration
Viral Process
Positive Regulation Of Peptidase Activity
Diacylglycerol Biosynthetic Process
Phenylalanyl-tRNA Aminoacylation
Activation Of Phospholipase A2 Activity
Regulation Of Progesterone Secretion
Negative Regulation Of Cell Growth
Regulation Of Secretion
Positive Regulation Of Phospholipase A2 Activity
Gamete Generation
Developmental Process
Regulation Of Proteolysis
Regulation Of Cell Proliferation
Positive Regulation Of Cellular Metabolic Process
Tail-anchored Membrane Protein Insertion Into ER Membrane
Developmental Process Involved In Reproduction
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Activin Receptor Signaling Pathway
Protein Insertion Into ER Membrane
Cullin Deneddylation
Sexual Reproduction
Multicellular Organismal Reproductive Process
Development Of Primary Sexual Characteristics
Multicellular Organism Reproduction
Negative Regulation Of Growth
Positive Regulation Of Phosphorylation
Protein Deneddylation
Germ Cell Development
Tagcloud
?
altogether
build
circuitry
coexpression
coregulating
coregulation
designing
discover
eleven
expand
foxd3
gdf3
hesc
hescs
hierarchy
irrespective
leftb
lin28
modules
nanog
pluripotency
pou5f1
regenerative
renewal
rex1
sox2
terf1
tfbss
upregulate
Tagcloud (Difference)
?
altogether
build
circuitry
coexpression
coregulating
coregulation
designing
discover
eleven
expand
foxd3
gdf3
hesc
hescs
hierarchy
irrespective
leftb
lin28
modules
nanog
pluripotency
pou5f1
regenerative
renewal
rex1
sox2
terf1
tfbss
upregulate
Tagcloud (Intersection)
?