ACVR1C and CRIPTO

Number of citations of the paper that reports this interaction (PubMedID 11485994)
71

Data Source:
HPRD (in vivo)

		ACVR1C	CRIPTO
Description		activin A receptor type 1C	cripto, EGF-CFC family member
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Activin Receptor Complex Serine/threonine Protein Kinase Complex	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Membrane Raft Side Of Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Activin Receptor Activity Growth Factor Binding Nodal Binding Metal Ion Binding	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding
	Biological Process	Trophectodermal Cell Proliferation Response To Dietary Excess Protein Phosphorylation Apoptotic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Response To Glucose Lipid Storage Insulin Secretion Cell Differentiation Apoptotic Nuclear Changes Regulation Of Cell Migration Response To Insulin Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Insulin Secretion Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation	Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Cellular Response To Type II Interferon Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin	Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS		A body shape index ( 34021172) Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Diastolic blood pressure ( 30224653) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731 33339817) Offspring birth weight ( 31043758) Reticulocyte count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 30578418) Total cholesterol levels ( 30275531 33339817) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		2 interacting genes: CRIPTO INHBB	22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2
Entrez ID		130399	6997
HPRD ID		10608	01757
Ensembl ID		ENSG00000123612	ENSG00000241186
Uniprot IDs		Q8NER5	F5H1T8 P13385
PDB IDs
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Host Cell Surface Receptor Binding Growth Factor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Hepatocyte Growth Factor Production Positive Regulation Of Ovulation Gland Development Cellular Response To Thyroglobulin Triiodothyronine Negative Regulation Of Follicle-stimulating Hormone Secretion Nodal Binding Response To Thyroglobulin Triiodothyronine Regulation Of Follicle-stimulating Hormone Secretion Cellular Response To Cytokine Stimulus Positive Regulation Of Follicle-stimulating Hormone Secretion Activin Receptor Binding Response To Insecticide Response To Peptide Cellular Response To Leptin Stimulus Response To Cytokine Negative Regulation Of Gonadotropin Secretion Cellular Response To Phorbol 13-acetate 12-myristate Anterior/posterior Axis Specification, Embryo Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Thyroid Hormone Stimulus Adhesion Of Symbiont To Host Cell Response To Phorbol 13-acetate 12-myristate Nodal Signaling Pathway Adhesion Of Symbiont To Host Cellular Response To Cholesterol Response To Hepatocyte Growth Factor Cellular Response To Hepatocyte Growth Factor Stimulus Cellular Response To Interleukin-6 Oocyte Development Cellular Response To Sterol Response To Leptin Seminiferous Tubule Development Response To Interleukin-6 Response To Thyroid Hormone Response To Cholesterol Cell Migration Involved In Sprouting Angiogenesis Female Gonad Development Pituitary Gland Development Response To Gonadotropin Embryonic Axis Specification Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of MAP Kinase Activity Blood Vessel Endothelial Cell Migration Mammary Gland Development Negative Regulation Of Insulin Secretion	Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of SMAD Protein Signal Transduction Activin Receptor Complex Enzyme-linked Receptor Protein Signaling Pathway Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Bone Mineralization Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway BMP Signaling Pathway Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Cellular Response To BMP Stimulus Cellular Response To Growth Factor Stimulus Regulation Of Ossification Positive Regulation Of Osteoblast Differentiation Regulation Of Bone Mineralization Response To Growth Factor Activin Receptor Activity, Type I Activin Binding Cell Surface Receptor Signaling Pathway Activin Receptor Activity Regulation Of Osteoblast Differentiation Growth Factor Binding Mesoderm Formation System Development Lung Development Mesoderm Development Animal Organ Development Regulation Of Multicellular Organismal Development Formation Of Primary Germ Layer BMP Receptor Activity Osteoblast Differentiation Outflow Tract Septum Morphogenesis Tissue Development Cardiac Septum Morphogenesis Growth Factor Activity Pattern Specification Process Heart Development Regulation Of Multicellular Organismal Process Activin Receptor Activity, Type II Regulation Of Reproductive Process Positive Regulation Of Cell Differentiation Developmental Process Involved In Reproduction Gastrulation Gastrulation With Mouth Forming Second Cytokine Activity Heart Valve Morphogenesis
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