ACVR1C and TDGF1

Number of citations of the paper that reports this interaction (PMID 11485994)
60

Data Source:
HPRD (in vivo)

		ACVR1C	TDGF1
Gene Name		activin A receptor, type IC	teratocarcinoma-derived growth factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Activin Receptor Complex	Extracellular Space Nucleus Golgi Apparatus Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity ATP Binding Activin Receptor Activity, Type I Growth Factor Binding Nodal Binding Metal Ion Binding	Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Response To Dietary Excess Protein Phosphorylation Response To Glucose Lipid Storage Signal Transduction By Phosphorylation Cell Differentiation Apoptotic Nuclear Changes Response To Insulin Nodal Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Insulin Secretion Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation	Activation Of MAPK Activity Vasculogenesis In Utero Embryonic Development Morphogenesis Of A Branching Structure Positive Regulation Of Cell-matrix Adhesion Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Gastrulation Heart Development Positive Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Mammary Gland Development Somatic Stem Cell Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cardiac Muscle Cell Differentiation Canonical Wnt Signaling Pathway Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Signaling by Activin Regulation of signaling by NODAL Signaling by NODAL	Transcriptional regulation of pluripotent stem cells Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by NODAL
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: INHBB TDGF1	10 interactors: ACVR1B ACVR1C ANG AP2S1 BAG6 COPS6 FARSA FBLN1 GDF9 LRIF1
Entrez ID		130399	6997
HPRD ID		10608	01757
Ensembl ID		ENSG00000123612	ENSG00000241186
Uniprot IDs		Q8NER5	F5H1T8 P13385
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Hepatocyte Growth Factor Biosynthetic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Negative Regulation Of Gonadotropin Secretion Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of MAPK Cascade Positive Regulation Of Protein Phosphorylation Cellular Response To Leptin Stimulus Response To Leptin Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Anterior/posterior Axis Specification, Embryo Cell Migration Involved In Sprouting Angiogenesis Regulation Of Protein Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Interleukin-6 Positive Regulation Of Cellular Protein Metabolic Process Response To Epidermal Growth Factor Negative Regulation Of Signaling Activin Receptor Signaling Pathway Response To Interleukin-6 Blood Vessel Endothelial Cell Migration Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Negative Regulation Of Cytokine Biosynthetic Process Defense Response Negative Regulation Of Insulin Secretion Negative Regulation Of Peptide Secretion Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Oocyte Development Regulation Of Apoptotic Process Oocyte Differentiation Regulation Of Phosphorus Metabolic Process Embryonic Axis Specification Regulation Of Cell Death Positive Regulation Of Cell-matrix Adhesion Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Sprouting Angiogenesis Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Hormone Secretion Positive Regulation Of Fibroblast Proliferation Regulation Of Intracellular Signal Transduction Anterior/posterior Axis Specification Somatic Stem Cell Maintenance	Nodal Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Activin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Reproductive Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Oocyte Development Oocyte Differentiation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Oogenesis Negative Regulation Of Chorionic Trophoblast Cell Proliferation Positive Regulation Of Trophoblast Cell Migration Oocyte Growth Female Gamete Generation Single Organism Reproductive Process Development Of Primary Female Sexual Characteristics Regulation Of Chorionic Trophoblast Cell Proliferation Negative Regulation Of Trophoblast Cell Migration Viral Process Positive Regulation Of Peptidase Activity Diacylglycerol Biosynthetic Process Phenylalanyl-tRNA Aminoacylation Activation Of Phospholipase A2 Activity Regulation Of Progesterone Secretion Negative Regulation Of Cell Growth Regulation Of Secretion Positive Regulation Of Phospholipase A2 Activity Gamete Generation Developmental Process Regulation Of Proteolysis Regulation Of Cell Proliferation Positive Regulation Of Cellular Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Developmental Process Involved In Reproduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activin Receptor Signaling Pathway Protein Insertion Into ER Membrane Cullin Deneddylation Sexual Reproduction Multicellular Organismal Reproductive Process Development Of Primary Sexual Characteristics Multicellular Organism Reproduction Negative Regulation Of Growth Positive Regulation Of Phosphorylation Protein Deneddylation Germ Cell Development
Tagcloud ?			altogether build circuitry coexpression coregulating coregulation designing discover eleven expand foxd3 gdf3 hesc hescs hierarchy irrespective leftb lin28 modules nanog pluripotency pou5f1 regenerative renewal rex1 sox2 terf1 tfbss upregulate
Tagcloud (Difference) ?			altogether build circuitry coexpression coregulating coregulation designing discover eleven expand foxd3 gdf3 hesc hescs hierarchy irrespective leftb lin28 modules nanog pluripotency pou5f1 regenerative renewal rex1 sox2 terf1 tfbss upregulate
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