ACVR1C

Description		activin A receptor type 1C
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Activin Receptor Complex Serine/threonine Protein Kinase Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity ATP Binding Kinase Activity Activin Receptor Activity, Type I Transferase Activity Activin Receptor Activity Growth Factor Binding Nodal Binding Metal Ion Binding
	Biological Process	Trophectodermal Cell Proliferation Response To Dietary Excess Protein Phosphorylation Apoptotic Process Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Nervous System Development Response To Glucose Lipid Storage Insulin Secretion Cell Differentiation Apoptotic Nuclear Changes Regulation Of Cell Migration Response To Insulin Activin Receptor Signaling Pathway Nodal Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Insulin Secretion Regulation Of Multicellular Organismal Process Cellular Response To Growth Factor Stimulus Apoptotic Signaling Pathway Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin
Drugs
Diseases
GWAS		A body shape index ( 34021172) Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Diastolic blood pressure ( 30224653) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731 33339817) Offspring birth weight ( 31043758) Reticulocyte count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Systolic blood pressure ( 30578418) Total cholesterol levels ( 30275531 33339817) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		2 interacting genes: CRIPTO INHBB
Entrez ID		130399
HPRD ID		10608
Ensembl ID		ENSG00000123612
Uniprot IDs		Q8NER5
PDB IDs
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Host Cell Surface Receptor Binding Growth Factor Activity Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Hepatocyte Growth Factor Production Positive Regulation Of Ovulation Gland Development Cellular Response To Thyroglobulin Triiodothyronine Negative Regulation Of Follicle-stimulating Hormone Secretion Nodal Binding Response To Thyroglobulin Triiodothyronine Regulation Of Follicle-stimulating Hormone Secretion Cellular Response To Cytokine Stimulus Positive Regulation Of Follicle-stimulating Hormone Secretion Activin Receptor Binding Response To Insecticide Response To Peptide Cellular Response To Leptin Stimulus Response To Cytokine Negative Regulation Of Gonadotropin Secretion Cellular Response To Phorbol 13-acetate 12-myristate Anterior/posterior Axis Specification, Embryo Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Thyroid Hormone Stimulus Adhesion Of Symbiont To Host Cell Response To Phorbol 13-acetate 12-myristate Nodal Signaling Pathway Adhesion Of Symbiont To Host Cellular Response To Cholesterol Response To Hepatocyte Growth Factor Cellular Response To Hepatocyte Growth Factor Stimulus Cellular Response To Interleukin-6 Oocyte Development Cellular Response To Sterol Response To Leptin Seminiferous Tubule Development Response To Interleukin-6 Response To Thyroid Hormone Response To Cholesterol Cell Migration Involved In Sprouting Angiogenesis Female Gonad Development Pituitary Gland Development Response To Gonadotropin Embryonic Axis Specification Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of MAP Kinase Activity Blood Vessel Endothelial Cell Migration Mammary Gland Development Negative Regulation Of Insulin Secretion
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