COL9A3 and COL2A1

Number of citations of the paper that reports this interaction (PubMedID 11724554)
0

Data Source:
HPRD (in vivo)

		COL9A3	COL2A1
Description		collagen type IX alpha 3 chain	collagen type II alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type IX Trimer Basement Membrane Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Collagen Trimer Fibrillar Collagen Trimer Collagen Type II Trimer Collagen Type XI Trimer Basement Membrane Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein Homodimerization Activity	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength MHC Class II Protein Binding Identical Protein Binding Protein Homodimerization Activity Proteoglycan Binding Metal Ion Binding Platelet-derived Growth Factor Binding
	Biological Process		Skeletal System Development Cartilage Condensation Ossification Tissue Homeostasis Endochondral Ossification Chondrocyte Differentiation Heart Morphogenesis Proteoglycan Metabolic Process Central Nervous System Development Visual Perception Sensory Perception Of Sound Regulation Of Gene Expression Collagen Fibril Organization Notochord Development Limb Morphogenesis Inner Ear Morphogenesis Animal Organ Development Skeletal System Morphogenesis System Development Inner Ear Development Cartilage Development Roof Of Mouth Development Limb Bud Formation Embryonic Skeletal Joint Morphogenesis Bone Development Cartilage Development Involved In Endochondral Bone Morphogenesis Otic Vesicle Development Cellular Response To BMP Stimulus Anterior Head Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization	Collagen degradation Collagen degradation Fibronectin matrix formation Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization Developmental Lineage of Pancreatic Ductal Cells
Drugs			Collagenase clostridium histolyticum
Diseases		Multiple epiphyseal dysplasia (MED)	Osteoarthritis with mild chondrodysplasia Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia
GWAS			Lymphocyte count ( 32888494) Macular thickness ( 30535121) Neutrophil percentage of white cells ( 32888494) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis ( 30891314) Triglyceride levels ( 32902719)
Interacting Genes		4 interacting genes: COL2A1 EGFR ERBB2 MAG	33 interacting genes: ANXA5 BGN BMP2 C1QA CHAD COL6A1 COL9A2 COL9A3 COMP DDR1 FGF7 FN1 HTRA1 HYAL1 ITGA2B KEAP1 LOXL4 MAG MATN1 MMP1 MMP13 PCOLCE PDGFA PDGFB PDIA2 PKD1 PRELP RELA SPARC TGFB1 TGFBI THBS1 TNFRSF10A
Entrez ID		1299	1280
HPRD ID		00374	00361
Ensembl ID		ENSG00000092758	ENSG00000139219
Uniprot IDs		Q14050	P02458
PDB IDs		5CTD 5CTI 5CVA 5CVB	1U5M 2FSE 2SEB 5NIR 5OCX 5OCY 6BIN 6HG7 6NIX 7NZE
Enriched GO Terms of Interacting Partners?		ERBB2-EGFR Signaling Pathway Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process ERBB2 Signaling Pathway Cellular Response To Growth Factor Stimulus Myelin Sheath Response To Growth Factor Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Cell Growth Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Response To Epidermal Growth Factor Epidermal Growth Factor Receptor Signaling Pathway Basal Plasma Membrane ERBB Signaling Pathway Ruffle Membrane Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Growth Myelination Axon Ensheathment Negative Regulation Of Cell Differentiation Multivesicular Body, Internal Vesicle Lumen Ossification Protein Tyrosine Kinase Activity Embryonic Organ Development Nervous System Process Positive Regulation Of Cell Growth Shc-EGFR Complex ERBB3:ERBB2 Complex Mesaxon Collagen Type II Trimer Negative Regulation Of Developmental Process Positive Regulation Of Protein Kinase C Signaling Epidermal Growth Factor Receptor Activity RNA Polymerase I Core Binding Ganglioside GT1b Binding Receptor Complex System Development Positive Regulation Of Epithelial Cell Proliferation Response To Wounding Membrane Raft Epidermal Growth Factor Binding Compact Myelin Collagen Type XI Trimer Anterior Head Development Regulation Of Protein Kinase C Signaling Transmembrane Signaling Receptor Activity Positive Regulation Of Protein Phosphorylation Basolateral Plasma Membrane	Extracellular Matrix Extracellular Region Collagen Binding Extracellular Matrix Structural Constituent Extracellular Space Animal Organ Development Cartilage Development Extracellular Matrix Binding Platelet Alpha Granule Lumen Developmental Process Cell Surface Extracellular Matrix Organization Extracellular Structure Organization Animal Organ Morphogenesis Endoplasmic Reticulum Lumen Response To Mechanical Stimulus Response To Wounding Anatomical Structure Morphogenesis Bone Development Heparin Binding Positive Regulation Of Cell Migration Positive Regulation Of Glial Cell Differentiation Basement Membrane Positive Regulation Of Cell Motility Platelet-derived Growth Factor Binding Golgi Lumen Tube Morphogenesis Positive Regulation Of Locomotion Angiogenesis Regulation Of Cell Adhesion Extracellular Exosome Proteoglycan Binding Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Skin Development Regulation Of Anatomical Structure Morphogenesis Cell Adhesion Platelet-derived Growth Factor Complex Negative Regulation Of Phosphatidylinositol Biosynthetic Process Bone Mineralization Positive Regulation Of MiRNA Transcription Positive Regulation Of Fibroblast Proliferation Chondrocyte Differentiation Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of Gliogenesis Positive Regulation Of Phosphorylation Collagen Metabolic Process Regulation Of Extracellular Matrix Organization Regulation Of Glial Cell Differentiation Connective Tissue Development
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