ATXN7L2 and CBX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		ATXN7L2	CBX1
Description		ataxin 7 like 2	chromobox 1
Image		No pdb structure
GO Annotations	Cellular Component		Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Heterochromatin Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Chromocenter Nuclear Body Site Of DNA Damage
	Molecular Function		Chromatin Binding Protein Binding Enzyme Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process		DNA Damage Response Heterochromatin Formation Negative Regulation Of DNA-templated Transcription
Pathways			HCMV Early Events
Drugs
Diseases
GWAS		Chronic kidney disease ( 20383146) Intelligence (MTAG) ( 29326435) Major depressive disorder ( 20125088)	Aspartate aminotransferase levels ( 33547301) Body mass index ( 20935630 26426971) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Generalized epilepsy ( 22949513)
Interacting Genes		27 interacting genes: BAG3 BANP CBX1 CBX3 CTIF CYSRT1 FSD2 GOLGA6L9 HSF2BP HSPB8 IKZF3 KCTD7 KRT31 LAMB1 MB21D2 MDFI PACSIN3 PPP1R16A PPP2R3A PRDM6 RBPMS SBK3 SH3RF1 SH3RF2 SSC4D USP54 ZNF526	34 interacting genes: ABI3BP ARL5A ATXN7L2 BAHD1 BARD1 BRCA1 CBX3 CBX5 CHAF1A DNMT1 DNMT3A DNMT3B EMSY H1-4 H3-4 H3C1 H3C3 HECW2 HSPB1 KLF11 LNX1 LRIF1 NR2F6 PCNA PIM1 RPL12 SP100 SUV39H1 TRIM24 TRIM28 UCHL1 VHL VTN ZNF280C
Entrez ID		127002	10951
HPRD ID		12506	05149
Ensembl ID		ENSG00000162650	ENSG00000108468
Uniprot IDs		A0A804HIT1 A0A804HIX1 A0A804HJY2 Q5T6C5	P83916 Q6IBN6
PDB IDs			2FMM 3F2U 3Q6S 5T1G 6D07 6D08
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Positive Regulation Of Aggrephagy Positive Regulation Of Catabolic Process Positive Regulation Of Protein Catabolic Process Cellular Response To Unfolded Protein Histone Methyltransferase Binding	Chromatin Organization Heterochromatin Chromatin Remodeling Epigenetic Regulation Of Gene Expression Heterochromatin Formation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA (cytosine-5-)-methyltransferase Activity Nucleoplasm Chromatin Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Euchromatin Chromo Shadow Domain Binding Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Epigenetic Programming Of Gene Expression Negative Regulation Of Biosynthetic Process Ubiquitin-protein Transferase Activity Chromosome Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Regulation Of Primary Metabolic Process DNA Damage Response Nucleosome Assembly Histone H2AK127 Ubiquitin Ligase Activity Nucleus Histone H2AK129 Ubiquitin Ligase Activity Regulation Of Macromolecule Metabolic Process BRCA1-BARD1 Complex Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of Metabolic Process Nucleosome Organization DNA Binding Cellular Response To Stress DNA-methyltransferase Activity BRCA1-B Complex Cellular Response To Bisphenol A Structural Constituent Of Chromatin Pericentric Heterochromatin Post-translational Protein Modification Protein-DNA Complex Assembly
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