PCP2 and GNAI3

Number of citations of the paper that reports this interaction (PubMedID 28514442)
50

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		PCP2	GNAI3
Description		Purkinje cell protein 2	G protein subunit alpha i3
Image		No pdb structure
GO Annotations	Cellular Component		Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Midbody Centriolar Satellite Ciliary Basal Body Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	G Protein-coupled Opsin Signaling Pathway	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Macroautophagy GTP Metabolic Process Cell Division
Pathways		G alpha (i) signalling events	Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs
Diseases
GWAS		Neuropathic pain in head and neck cancer ( 29884837)	Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)
Interacting Genes		4 interacting genes: GNAI1 GNAI2 GNAI3 MEOX1	45 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 DVL1 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SNCA SOX30 TSHR
Entrez ID		126006	2773
HPRD ID		18723	00765
Ensembl ID		ENSG00000174788	ENSG00000065135
Uniprot IDs		Q8IVA1	P08754
PDB IDs			2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S 7E9H 7KH0 7RA3 7RGP 7T10 7T11 7X6I 8GVX 8JD6 8K9L 8OY1 8SZH 8SZI 8WGB 9AVL
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Midbody Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway GTPase Activity Ciliary Basal Body GTP Binding Cell Division GDP Binding Centrosome G Protein-coupled Receptor Signaling Pathway Centriolar Satellite Negative Regulation Of Secretion By Cell Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity D2 Dopamine Receptor Binding Negative Regulation Of Secretion Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Sclerotome Development Adenylate Cyclase Inhibitor Activity Adenylate Cyclase Regulator Activity Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Somite Specification Positive Regulation Of Protein Localization To Cell Cortex Positive Regulation Of Metabolic Process Regulation Of Protein Localization To Cell Cortex Negative Regulation Of Calcium Ion-dependent Exocytosis G Protein-coupled Adenosine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Cytoskeleton Positive Regulation Of Urine Volume Lysosomal Membrane HMG Box Domain Binding Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Nucleotide Binding Cellular Response To Forskolin Negative Regulation Of Transport Regulation Of Relaxation Of Muscle Segment Specification Somite Development Response To Forskolin Positive Regulation Of Cholesterol Biosynthetic Process G Protein-coupled Serotonin Receptor Signaling Pathway Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Urine Volume	G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity GTPase Activator Activity Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling GTPase Regulator Activity GDP-dissociation Inhibitor Activity G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane Synapse Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Dendrite Regulation Of GTPase Activity Cytoplasm Melatonin Receptor Activity Dendritic Spine Response To Amphetamine Positive Regulation Of GTPase Activity Signaling Receptor Complex Adaptor Activity Glutamatergic Synapse Dopamine Uptake Involved In Synaptic Transmission Cell-cell Signaling Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Response To Amine Positive Regulation Of Hydrolase Activity Cell Communication Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Presynapse Catecholamine Uptake Dopamine Uptake Visual Learning Presynaptic Membrane Regulation Of Blood Circulation Visual Behavior
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