AFP

Name	alpha fetoprotein
Structure
Interactors	14 interactors: AP4S1 CASP3 CCR5 CREBBP EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 PTEN SGSM2 SIRT1 XIAP
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding Small Molecule Binding Metal Ion Binding
	Biological Process	Ovulation From Ovarian Follicle Apoptotic Process Immune Response Sexual Reproduction Response To Nutrient Levels Progesterone Metabolic Process Homeostasis Of Number Of Cells
Pathways	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
GWAS	Blood protein levels ( 30072576 ) Prostate cancer ( 23535732 ) Tumor biomarkers ( 23300138 )
Entrez ID	174
HPRD ID	00074
Ensembl ID	ENSG00000081051
Uniprot IDs	P02771
PDB IDs	3MRK 7RE7 7RE8 7YIM 8X1N
GO Terms Enriched among Interactors ?	Intracellular Signal Transduction Regulation Of Protein Stability Cell Death Apoptotic Process Programmed Cell Death Endopeptidase Activity Rhythmic Process Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Cytoplasm Death Receptor Binding Negative Regulation Of Cellular Senescence Execution Phase Of Apoptosis Response To UV DNA Damage Response Regulation Of Myeloid Cell Apoptotic Process Protein Acetylation Innate Immune Response-activating Signaling Pathway Post-translational Protein Modification Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Positive Regulation Of Defense Response Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ovulation Cycle Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Programmed Cell Death Protein Metabolic Process Regulation Of Cellular Senescence Negative Regulation Of Synaptic Vesicle Clustering NAD-dependent Protein Decrotonylase Activity Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Maintenance Of Nucleus Location Histone Decrotonylase Activity, NAD-dependent Histone H3K14 Deacetylase Activity, NAD-dependent Negative Regulation Of Cellular Response To Testosterone Stimulus Histone H3K Deacetylase Activity Protein Stabilization Protein Modification Process Positive Regulation Of Protein Linear Polyubiquitination Response To Stress Regulation Of Apoptosis Involved In Tissue Homeostasis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Canonical NF-kappaB Signal Transduction Response To Hypoxia Phospholipase A2 Activator Activity Chemokine (C-C Motif) Ligand 5 Binding P53 Binding