AFP and PHB2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AFP	PHB2
Description		alpha fetoprotein	prohibitin 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Plasma Membrane Cell Surface Membrane Nuclear Matrix Protein-containing Complex Mitochondrial Prohibitin Complex Cell Periphery Inner Mitochondrial Membrane Protein Complex
	Molecular Function	Protein Binding Small Molecule Binding Metal Ion Binding	Protein Binding Nuclear Estrogen Receptor Binding Amide Binding Identical Protein Binding Protein Homodimerization Activity Sphingolipid Binding Protein Heterodimerization Activity
	Biological Process	Ovulation From Ovarian Follicle Apoptotic Process Immune Response Sexual Reproduction Response To Nutrient Levels Progesterone Metabolic Process Homeostasis Of Number Of Cells	Mitophagy Positive Regulation Of Immunoglobulin Production Protein Import Into Nucleus Mitochondrion Organization Sister Chromatid Cohesion Cell Migration Regulation Of Complement Activation Estrogen Receptor Signaling Pathway Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Mammary Gland Epithelial Cell Proliferation RIG-I Signaling Pathway B Cell Activation Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of DNA-templated Transcription Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Antiviral Innate Immune Response Regulation Of Cardiolipin Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Cytochrome-c Oxidase Activity
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Processing of SMDT1 Cellular response to mitochondrial stress
Drugs			Capsaicin Rocaglamide Didesmethylrocaglamide
Diseases
GWAS		Blood protein levels ( 30072576) Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)	Glycated hemoglobin levels ( 28898252 34059833) Red blood cell fatty acid levels ( 25500335) Refractive error ( 32231278)
Interacting Genes		14 interacting genes: AP4S1 CASP3 CCR5 CREBBP EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 PTEN SGSM2 SIRT1 XIAP	26 interacting genes: AFP AKT1 ANXA1 CDC42 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MEF2A MRPS18B MYOD1 NR2F1 NR2F2 PPARG PPP1CA PRKCA PRKN PTEN PTMA RNF2 TEAD3 UPF2 VHL
Entrez ID		174	11331
HPRD ID		00074	17843
Ensembl ID		ENSG00000081051	ENSG00000215021
Uniprot IDs		P02771	A0A7I2V5F0 Q99623
PDB IDs		3MRK 7RE7 7RE8 7YIM 8X1N	6IQE 8J4I 8RRH
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Regulation Of Protein Stability Cell Death Apoptotic Process Programmed Cell Death Endopeptidase Activity Rhythmic Process Peptidyl-lysine Acetylation Regulation Of Cellular Response To Heat Cytoplasm Death Receptor Binding Negative Regulation Of Cellular Senescence Execution Phase Of Apoptosis Response To UV DNA Damage Response Regulation Of Myeloid Cell Apoptotic Process Protein Acetylation Innate Immune Response-activating Signaling Pathway Post-translational Protein Modification Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Positive Regulation Of Defense Response Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Ovulation Cycle Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Activation Of Innate Immune Response Regulation Of Programmed Cell Death Protein Metabolic Process Regulation Of Cellular Senescence Negative Regulation Of Synaptic Vesicle Clustering NAD-dependent Protein Decrotonylase Activity Histone H4K12 Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Maintenance Of Nucleus Location Histone Decrotonylase Activity, NAD-dependent Histone H3K14 Deacetylase Activity, NAD-dependent Negative Regulation Of Cellular Response To Testosterone Stimulus Histone H3K Deacetylase Activity Protein Stabilization Protein Modification Process Positive Regulation Of Protein Linear Polyubiquitination Response To Stress Regulation Of Apoptosis Involved In Tissue Homeostasis Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Canonical NF-kappaB Signal Transduction Response To Hypoxia Phospholipase A2 Activator Activity Chemokine (C-C Motif) Ligand 5 Binding P53 Binding	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Enzyme Binding Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Rhythmic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Gene Expression Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Developmental Process Positive Regulation Of Metabolic Process Histone Deacetylase Activity, Hydrolytic Mechanism Chromatin Binding Negative Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Protein Lysine Deacetylase Activity Protein Lysine Delactylase Activity Transcription Corepressor Binding Response To Hormone Protein Decrotonylase Activity Histone Decrotonylase Activity Histone Deacetylase Activity Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Histone Deacetylase Binding Cellular Developmental Process Regulation Of Programmed Cell Death Regulation Of Primary Metabolic Process
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