AFP and EHD4

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		AFP	EHD4
Gene Name		alpha-fetoprotein	EH-domain containing 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm	Nucleus Endoplasmic Reticulum Plasma Membrane Membrane Early Endosome Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Metal Ion Binding	Nucleic Acid Binding Calcium Ion Binding Protein Binding ATP Binding GTP Binding
	Biological Process	Ovulation From Ovarian Follicle Transport Progesterone Metabolic Process SMAD Protein Signal Transduction	Pinocytosis Regulation Of Endocytosis Endocytic Recycling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Homooligomerization Cellular Response To Growth Factor Stimulus
Pathways
Drugs
Diseases
GWAS		Prostate cancer ( 23535732) Tumor biomarkers ( 23300138)
Protein-Protein Interactions		10 interactors: AP4S1 CCR5 EHD4 GNB1 MED27 PHB2 PIDD1 PSMB7 SGSM2 XIAP	2 interactors: AFP RASGRF1
Entrez ID		174	30844
HPRD ID		00074	10435
Ensembl ID		ENSG00000081051	ENSG00000103966
Uniprot IDs		P02771	A8K9B9 Q9H223
PDB IDs		3MRK
Enriched GO Terms of Interacting Partners?		DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Regulation Of Signal Transduction Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Intracellular Signal Transduction Programmed Cell Death Regulation Of Signaling Cell Death Death Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Cell Cycle Arrest Positive Regulation Of Cellular Protein Metabolic Process Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Metal Ion Homeostasis Positive Regulation Of Protein Linear Polyubiquitination Signal Transduction By P53 Class Mediator Positive Regulation Of Protein Metabolic Process Positive Regulation Of Canonical Wnt Signaling Pathway Late Endosome To Golgi Transport Ion Homeostasis Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Ubiquitination Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Mitotic Cell Cycle Checkpoint Regulation Of Proteolysis Mammary Gland Branching Involved In Thelarche Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Cellular Response To Stress Cytosolic Calcium Ion Homeostasis Cardiac Muscle Cell Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Muscle Cell Apoptotic Process Regulation Of Protein Ubiquitination Endosomal Transport Regulation Of Cysteine-type Endopeptidase Activity Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Ovulation From Ovarian Follicle Activation Of Rac GTPase Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Ovulation Progesterone Metabolic Process C21-steroid Hormone Metabolic Process Regulation Of Rac Protein Signal Transduction Activation Of Rho GTPase Activity Long-term Memory Activation Of Ras GTPase Activity Positive Regulation Of Ras Protein Signal Transduction SMAD Protein Signal Transduction Positive Regulation Of Rac GTPase Activity Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of Small GTPase Mediated Signal Transduction Cellular Ketone Metabolic Process Ovulation Cycle Process Female Gonad Development Female Gamete Generation Ovulation Cycle Development Of Primary Female Sexual Characteristics Regulation Of Receptor Activity Memory
Tagcloud ?		acetylate acetyltransferase actinomycin amplifies coexpression corepressors developmental developmentally displacement dissecting electromobility eliminates exclusive fetoprotein fibroblast hepatic hepatocellular hnf hypoxic lost mutually passive represses repression repressive repressor serves staged transfection
Tagcloud (Difference) ?		acetylate acetyltransferase actinomycin amplifies coexpression corepressors developmental developmentally displacement dissecting electromobility eliminates exclusive fetoprotein fibroblast hepatic hepatocellular hnf hypoxic lost mutually passive represses repression repressive repressor serves staged transfection
Tagcloud (Intersection) ?