LEO1 and PAF1

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (two hybrid, biochemical)

		LEO1	PAF1
Gene Name		Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cdc73/Paf1 Complex	Cdc73/Paf1 Complex
	Molecular Function	Protein Binding	RNA Polymerase II Core Binding Chromatin Binding Protein Binding
	Biological Process	Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Lipopolysaccharide
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CSNK2A1 CTNNB1 HIST1H1C PAF1 POLR2A TCEA1	12 interactors: FXR2 HIST1H1C HIST1H3A KAT8 KMT2A LEO1 MLLT1 MSL1 MSL2 MSL3 RNF20 TCEA1
Entrez ID		123169	54623
HPRD ID		11231	10140
Ensembl ID		ENSG00000166477	ENSG00000006712
Uniprot IDs		Q8WVC0	M0QX35 Q8N7H5
PDB IDs		4M6T	4M6T
Enriched GO Terms of Interacting Partners?		Endodermal Cell Fate Commitment Stem Cell Maintenance Cell Fate Commitment Involved In Formation Of Primary Germ Layer Stem Cell Development Endodermal Cell Differentiation Wnt Signaling Pathway Transcription-coupled Nucleotide-excision Repair Stem Cell Differentiation Transcription, DNA-templated Positive Regulation Of Viral Transcription RNA Biosynthetic Process Endoderm Formation Regulation Of DNA-templated Transcription, Elongation Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process Regulation Of Chromosome Segregation Negative Regulation Of Myeloid Cell Differentiation Endoderm Development DNA-templated Transcription, Elongation Positive Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Positive Regulation Of Gene Expression RNA Metabolic Process Regulation Of Fibroblast Proliferation Positive Regulation Of Cellular Biosynthetic Process Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Formation Of Primary Germ Layer Cellular Macromolecule Biosynthetic Process Cell Development Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription, RNA-templated Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Regulation Of Viral Process Neuron Migration Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development	Histone H4-K16 Acetylation Chromatin Organization Histone H4 Acetylation Chromosome Organization Histone Modification Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Chromatin Modification Peptidyl-lysine Modification Organelle Organization Histone H2B Ubiquitination Histone Monoubiquitination Peptidyl-amino Acid Modification Regulation Of Gene Expression Histone Ubiquitination Positive Regulation Of Histone Methylation Protein Monoubiquitination Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Cellular Protein Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Histone Methylation Regulation Of DNA-templated Transcription, Elongation Cellular Protein Modification Process Regulation Of RNA Metabolic Process DNA Methylation Transcription, DNA-templated Positive Regulation Of Cellular Response To Drug Positive Regulation Of Macromolecule Biosynthetic Process Gene Expression RNA Biosynthetic Process Positive Regulation Of Histone Modification Positive Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process DNA Modification Regulation Of Histone H3-K14 Acetylation Regulation Of Cellular Response To Drug Protein Metabolic Process Nucleosome Assembly Regulation Of Histone Modification Chromatin Assembly Nucleosome Organization Regulation Of Metabolic Process Regulation Of Response To Drug
Tagcloud ?		advantage aml comprehensively confers demethylase destabilization discovered h3k9me3 independence jmjd2c mediates mediator myelogenous occupancy oncogenes oncogenic overexpressed paf perturbed phenotypes prl prl3 proteomics repressive reverses screen silac sox2 sox4	ablates ada2 ap2 apicomplexa apicomplexan dd ddhagcn5b destabilization dispensable e703g gcn5a gcn5b gondii indispensable invertebrates kat kats leo1 lytic parasite parasites phylum possessing proteomics protozoan redundant rrm tfiid toxoplasma
Tagcloud (Difference) ?		advantage aml comprehensively confers demethylase discovered h3k9me3 independence jmjd2c mediates mediator myelogenous occupancy oncogenes oncogenic overexpressed paf perturbed phenotypes prl prl3 repressive reverses screen silac sox2 sox4	ablates ada2 ap2 apicomplexa apicomplexan dd ddhagcn5b dispensable e703g gcn5a gcn5b gondii indispensable invertebrates kat kats lytic parasite parasites phylum possessing protozoan redundant rrm tfiid toxoplasma
Tagcloud (Intersection) ?		destabilization leo1 proteomics