LEO1 and CTNNB1

Number of citations of the paper that reports this interaction (PMID 16630820)
72

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		LEO1	CTNNB1
Gene Name		Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	catenin (cadherin-associated protein), beta 1, 88kDa
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cdc73/Paf1 Complex	Spindle Pole Nucleus Nucleoplasm Transcription Factor Complex Nuclear Euchromatin Cytoplasm Centrosome Cytosol Plasma Membrane Cell-cell Junction Adherens Junction Cell-cell Adherens Junction Fascia Adherens Tight Junction Focal Adhesion Cell Cortex Membrane Basolateral Plasma Membrane Lateral Plasma Membrane Catenin Complex Z Disc Lamellipodium Cell Junction Beta-catenin Destruction Complex Microvillus Membrane Protein-DNA Complex Scrib-APC-beta-catenin Complex Dendritic Shaft Apical Part Of Cell Synapse Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Beta-catenin-TCF7L2 Complex Cell Periphery
	Molecular Function	Protein Binding	RNA Polymerase II Activating Transcription Factor Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Signal Transducer Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Enzyme Binding Kinase Binding Protein Phosphatase Binding Estrogen Receptor Binding Protein Complex Binding Ionotropic Glutamate Receptor Binding Nuclear Hormone Receptor Binding Transcription Regulatory Region DNA Binding Ion Channel Binding Alpha-catenin Binding Cadherin Binding SMAD Binding Androgen Receptor Binding Nitric-oxide Synthase Binding I-SMAD Binding R-SMAD Binding Repressing Transcription Factor Binding Euchromatin Binding
	Biological Process	Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Axis Specification Patterning Of Blood Vessels Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Gastrulation With Mouth Forming Second Cell Fate Specification Endodermal Cell Fate Commitment Neuron Migration Epithelial To Mesenchymal Transition Neural Plate Development Liver Development Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Lens Morphogenesis In Camera-type Eye Regulation Of Secondary Heart Field Cardioblast Proliferation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Transcription, DNA-templated Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Adhesion Cell-matrix Adhesion Ectoderm Development Glial Cell Fate Determination Midgut Development Negative Regulation Of Cell Proliferation Anterior/posterior Axis Specification Dorsal/ventral Axis Specification Proximal/distal Pattern Formation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Schwann Cell Proliferation Wnt Signaling Pathway Single Organismal Cell-cell Adhesion Stem Cell Maintenance Layer Formation In Cerebral Cortex Central Nervous System Vasculogenesis Osteoclast Differentiation Androgen Receptor Signaling Pathway Male Genitalia Development Regulation Of Centriole-centriole Cohesion Pancreas Development Hair Follicle Morphogenesis Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Type I Interferon Production T Cell Differentiation In Thymus Negative Regulation Of Protein Sumoylation Response To Cytokine Adherens Junction Assembly Protein Localization To Cell Surface Embryonic Heart Tube Development Genitalia Morphogenesis Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Hair Cell Differentiation Embryonic Skeletal Limb Joint Morphogenesis Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Response To Drug Regulation Of Cell Fate Specification Muscle Cell Differentiation Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Innate Immune Response Myoblast Differentiation Bone Resorption Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Mitotic Cell Cycle, Embryonic Response To Cadmium Ion Regulation Of Fibroblast Proliferation Cell Maturation Synaptic Vesicle Transport Thymus Development Oocyte Development Embryonic Foregut Morphogenesis Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Oligodendrocyte Differentiation Synapse Organization Smooth Muscle Cell Differentiation Positive Regulation Of Muscle Cell Differentiation Protein Heterooligomerization Positive Regulation Of Histone H3-K4 Methylation Oviduct Development Canonical Wnt Signaling Pathway Trachea Formation Epithelial Tube Branching Involved In Lung Morphogenesis Lung Cell Differentiation Lung-associated Mesenchyme Development Lung Induction Epithelial Cell Differentiation Involved In Prostate Gland Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Hair Follicle Placode Formation Mesenchymal Cell Proliferation Involved In Lung Development Endothelial Tube Morphogenesis Fungiform Papilla Formation Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Sympathetic Ganglion Development Regulation Of Centromeric Sister Chromatid Cohesion Cellular Response To Mechanical Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Indole-3-methanol Renal Vesicle Formation Renal Inner Medulla Development Renal Outer Medulla Development Nephron Tubule Formation Regulation Of Nephron Tubule Epithelial Cell Differentiation Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Calcium Ion Import Negative Regulation Of Neuron Death Cellular Response To Insulin-like Growth Factor Stimulus Regulation Of Protein Localization To Cell Surface Positive Regulation Of Determination Of Dorsal Identity Positive Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Apoptotic Signaling Pathway
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	APC truncation mutants have impaired AXIN binding misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated TCF7L2 mutants don't bind CTBP truncated APC mutants destabilize the destruction complex Signaling by Wnt binding of TCF/LEF:CTNNB1 to target gene promoters deactivation of the beta-catenin transactivating complex APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane S37 mutants of beta-catenin aren't phosphorylated Degradation of beta-catenin by the destruction complex AXIN mutants destabilize the destruction complex, activating WNT signaling RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated XAV939 inhibits tankyrase, stabilizing AXIN Innate Immune System truncations of AMER1 destabilize the destruction complex CDO in myogenesis misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Cytosolic sensors of pathogen-associated DNA formation of the beta-catenin:TCF transactivating complex phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated repression of WNT target genes beta-catenin independent WNT signaling deletions in the AMER1 gene destabilize the destruction complex Ca2+ pathway Myogenesis AMER1 mutants destabilize the destruction complex TCF dependent signaling in response to WNT LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer
Drugs			Urea
Diseases
GWAS			Bone mineral density ( 22504420) Bone mineral density (hip) ( 19801982)
Protein-Protein Interactions		6 interactors: CSNK2A1 CTNNB1 HIST1H1C PAF1 POLR2A TCEA1	172 interactors: ACP1 AJAP1 AKT1 AMER1 APC APC2 APP AR ARHGAP32 ASH2L AXIN1 AXIN2 BCL3 BCL9 BCL9L BOC BRCA1 BTRC CA9 CARM1 CASP3 CASP8 CBL CBY1 CCND1 CDC27 CDC73 CDH1 CDH11 CDH15 CDH16 CDH2 CDH24 CDH3 CDH5 CDH7 CDH8 CDH9 CDK2 CDK5R1 CDK6 CDON CEBPA CHD8 CHUK CREBBP CSNK1A1 CSNK1D CSNK2A1 CSNK2B CTNNA1 CTNNA3 CTNNBIP1 CTNND2 DLG5 DSC3 DVL1 DVL3 EGFR ELAVL1 EP300 ERBB2 ERBB2IP ESR1 EZR FER FHIT FHL2 FLT1 FOXO1 FOXO4 FSCN1 FUS FYN GLIS2 GNA13 GRIK2 GRIN1 GRIN2D GSK3B HDAC6 HIF1A HIST1H1C HNF1A IGF2BP1 IKBKB IQGAP1 JADE1 KAT2A KAT2B KDR KMT2A KMT2D LATS2 LEF1 LEO1 MAGI1 MAGI2 MAPK8 MAPK9 MEN1 MET MITF MUC1 NCOA2 NDRG1 NEK2 NEURL2 NF2 NFKB1 NOTCH1 NR5A1 PECAM1 PICK1 PIK3R1 PIN1 PITX2 PKD1 PKP2 PLK1 PPM1A PSEN1 PSEN2 PTGS2 PTPN1 PTPN13 PTPN14 PTPN6 PTPRF PTPRJ PTPRK PTPRM PTPRU PTPRZ1 PYGO1 RAPGEF2 RBBP5 RBX1 RUVBL1 RUVBL2 RXRA SALL1 SIAH1 SKP1 SLC9A3R1 SMAD2 SMAD3 SMAD4 SMAD7 SMARCA4 SMARCA5 SOX1 SOX17 SPN SRC TAX1BP3 TBL1X TCF3 TCF4 TCF7L1 TCF7L2 TFAP2A TGFBR1 TGFBR2 TLE1 TRIP10 TRRAP UBE2B UBE2D1 UHRF2 USP9X ZFYVE9
Entrez ID		123169	1499
HPRD ID		11231	00286
Ensembl ID		ENSG00000166477	ENSG00000168036
Uniprot IDs		Q8WVC0	P35222
PDB IDs		4M6T	1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2G57 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS
Enriched GO Terms of Interacting Partners?		Endodermal Cell Fate Commitment Stem Cell Maintenance Cell Fate Commitment Involved In Formation Of Primary Germ Layer Stem Cell Development Endodermal Cell Differentiation Wnt Signaling Pathway Transcription-coupled Nucleotide-excision Repair Stem Cell Differentiation Transcription, DNA-templated Positive Regulation Of Viral Transcription RNA Biosynthetic Process Endoderm Formation Regulation Of DNA-templated Transcription, Elongation Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process Regulation Of Chromosome Segregation Negative Regulation Of Myeloid Cell Differentiation Endoderm Development DNA-templated Transcription, Elongation Positive Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Positive Regulation Of Gene Expression RNA Metabolic Process Regulation Of Fibroblast Proliferation Positive Regulation Of Cellular Biosynthetic Process Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Formation Of Primary Germ Layer Cellular Macromolecule Biosynthetic Process Cell Development Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription, RNA-templated Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Regulation Of Viral Process Neuron Migration Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development	Positive Regulation Of Cellular Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Positive Regulation Of Gene Expression Signaling Cell Communication Signal Transduction Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Multicellular Organismal Development Regulation Of Metabolic Process Response To Stimulus Developmental Process Negative Regulation Of Signaling Wnt Signaling Pathway Anatomical Structure Morphogenesis Cell Differentiation Negative Regulation Of Signal Transduction System Development Regulation Of Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Tissue Development Negative Regulation Of Cellular Metabolic Process Cell Development Regulation Of Wnt Signaling Pathway Regulation Of Cell Differentiation Regulation Of Cellular Process Regulation Of Nitrogen Compound Metabolic Process Response To Organic Substance Regulation Of Protein Metabolic Process Cellular Protein Modification Process Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Epithelium Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Signal Transduction Regulation Of RNA Metabolic Process Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Enzyme Linked Receptor Protein Signaling Pathway Negative Regulation Of Transcription, DNA-templated
Tagcloud ?		advantage aml comprehensively confers demethylase destabilization discovered h3k9me3 independence jmjd2c mediates mediator myelogenous occupancy oncogenes oncogenic overexpressed paf perturbed phenotypes prl prl3 proteomics repressive reverses screen silac sox2 sox4	acc acquires adrenal adrenocortical altering came centripetal compr cortex detail examining exome gland igf2 landscape medulla mutational opening perspectives physiol played prognostication progress steroidogenic subcapsular summarizes tracing zonation zones
Tagcloud (Difference) ?		advantage aml comprehensively confers demethylase destabilization discovered h3k9me3 independence jmjd2c mediates mediator myelogenous occupancy oncogenes oncogenic overexpressed paf perturbed phenotypes prl prl3 proteomics repressive reverses screen silac sox2 sox4	acc acquires adrenal adrenocortical altering came centripetal compr cortex detail examining exome gland igf2 landscape medulla mutational opening perspectives physiol played prognostication progress steroidogenic subcapsular summarizes tracing zonation zones
Tagcloud (Intersection) ?