LEO1

Gene Name		Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cdc73/Paf1 Complex
	Molecular Function	Protein Binding
	Biological Process	Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS
Protein-protein Interactions		6 interactors: CSNK2A1 CTNNB1 HIST1H1C PAF1 POLR2A TCEA1
Entrez ID		123169
HPRD ID		11231
Ensembl ID		ENSG00000166477
Uniprot IDs		Q8WVC0
PDB IDs		4M6T
Enriched GO Terms of Interacting Partners?		Endodermal Cell Fate Commitment Stem Cell Maintenance Cell Fate Commitment Involved In Formation Of Primary Germ Layer Stem Cell Development Endodermal Cell Differentiation Wnt Signaling Pathway Transcription-coupled Nucleotide-excision Repair Stem Cell Differentiation Transcription, DNA-templated Positive Regulation Of Viral Transcription RNA Biosynthetic Process Endoderm Formation Regulation Of DNA-templated Transcription, Elongation Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process Regulation Of Chromosome Segregation Negative Regulation Of Myeloid Cell Differentiation Endoderm Development DNA-templated Transcription, Elongation Positive Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Positive Regulation Of Gene Expression RNA Metabolic Process Regulation Of Fibroblast Proliferation Positive Regulation Of Cellular Biosynthetic Process Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Formation Of Primary Germ Layer Cellular Macromolecule Biosynthetic Process Cell Development Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription, RNA-templated Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Regulation Of Viral Process Neuron Migration Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development
Tagcloud ?		advantage aml comprehensively confers demethylase destabilization discovered h3k9me3 independence jmjd2c mediates mediator myelogenous occupancy oncogenes oncogenic overexpressed paf perturbed phenotypes prl prl3 proteomics repressive reverses screen silac sox2 sox4