LEO1 and TCEA1

Number of citations of the paper that reports this interaction (PubMedID 20178742)
48

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology)

		LEO1	TCEA1
Description		LEO1 component of Paf1/RNA polymerase II complex	transcription elongation factor A1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Centrosome Cdc73/Paf1 Complex	Nucleus Nucleoplasm Transcription Factor TFIID Complex Nucleolus
	Molecular Function	Protein Binding RNA Polymerase II C-terminal Domain Phosphoserine Binding	Nucleic Acid Binding DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Endodermal Cell Fate Commitment Transcription Elongation By RNA Polymerase II Wnt Signaling Pathway Stem Cell Population Maintenance MRNA 3'-end Processing Positive Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	DNA-templated Transcription Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Erythrocyte Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Frailty index ( 34431594)	Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		9 interacting genes: CSNK2A1 CTNNB1 DYRK1A ERCC6 GPRASP3 H1-2 POLR2A TCEA1 TCEA3	20 interacting genes: APP CDC73 CDK7 CEBPA CIRSR CTDP1 CTR9 EAF2 GPKOW GTF2E1 GTF2F2 IWS1 LEO1 PAF1 POLR2A REXO1 RTF1 SKIC8 SUPT6H UBR5
Entrez ID		123169	6917
HPRD ID		11231	03252
Ensembl ID		ENSG00000166477	ENSG00000187735
Uniprot IDs		Q8WVC0	A0A384MTX4 B7Z4W0 P23193
PDB IDs		4M6T 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH2	1TFI 3NDQ 5IY6 5IY7 5IY8 5IYA 5IYB 5IYC 6O9L 6ZUY 6ZV4 7CNF 7UNC 7UND 8A40 8UIS 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2 9J0N
Enriched GO Terms of Interacting Partners?		DNA-templated Transcription Elongation DNA-templated Transcription Transcription Elongation By RNA Polymerase II Double-strand Break Repair Via Nonhomologous End Joining Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Nucleic Acid Metabolic Process Transcription By RNA Polymerase II Double-strand Break Repair Via Classical Nonhomologous End Joining Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleobase-containing Compound Biosynthetic Process Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Nucleus Double-strand Break Repair Negative Regulation Of DNA Repair Regulation Of Gene Expression Negative Regulation Of Double-strand Break Repair Positive Regulation Of RNA Splicing Negative Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA Recombination Macromolecule Biosynthetic Process Euchromatin Negative Regulation Of Nucleobase-containing Compound Metabolic Process Glial Cell Fate Determination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of DNA-templated Transcription, Elongation Histone H3T45 Kinase Activity Negative Regulation Of Cell Cycle Regulation Of Macromolecule Metabolic Process Regulation Of Double-strand Break Repair Via Homologous Recombination Mesenchymal Stem Cell Differentiation Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Beta-catenin-ICAT Complex Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Renal Outer Medulla Development Renal Vesicle Formation Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development	Transcription Elongation By RNA Polymerase II DNA-templated Transcription Elongation RNA Metabolic Process Cdc73/Paf1 Complex Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Endodermal Cell Fate Commitment Nucleobase-containing Compound Biosynthetic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Macromolecule Metabolic Process Macromolecule Biosynthetic Process Nucleoplasm Nucleus MRNA Metabolic Process Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Myeloid Cell Differentiation Regulation Of DNA-templated Transcription Elongation Regulation Of RNA Metabolic Process Stem Cell Population Maintenance Maintenance Of Cell Number Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Processing Wnt Signaling Pathway Positive Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Cell Fate Commitment Regulation Of Macromolecule Biosynthetic Process RNA 3'-end Processing RNA Processing Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Myeloid Cell Differentiation Positive Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Complex Binding Negative Regulation Of Developmental Process Regulation Of Hemopoiesis Positive Regulation Of Biosynthetic Process Negative Regulation Of Cell Differentiation MRNA 3'-end Processing Positive Regulation Of RNA Metabolic Process Transcription Initiation At RNA Polymerase II Promoter Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation
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