LEO1 and TCEA1

Number of citations of the paper that reports this interaction (PMID 20178742)
58

Data Source:
BioGRID (pull down, affinity chromatography technology)

		LEO1	TCEA1
Gene Name		Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)	transcription elongation factor A (SII), 1
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Nucleolus Cdc73/Paf1 Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding	DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Endodermal Cell Fate Commitment Transcription, DNA-templated MRNA Polyadenylation Histone Monoubiquitination Wnt Signaling Pathway Stem Cell Maintenance Positive Regulation Of MRNA 3'-end Processing Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Erythrocyte Differentiation Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	Nucleotide Excision Repair Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription HIV Infection Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery Formation of transcription-coupled NER (TC-NER) repair complex RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Transcription-coupled NER (TC-NER) HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: CSNK2A1 CTNNB1 HIST1H1C PAF1 POLR2A TCEA1	17 interactors: APP CDC73 CDK7 CIR1 CTDP1 CTR9 EAF2 GTF2E1 GTF2F2 IWS1 LEO1 PAF1 POLR2A REXO1 RTF1 UBR5 WDR61
Entrez ID		123169	6917
HPRD ID		11231	03252
Ensembl ID		ENSG00000166477	ENSG00000187735
Uniprot IDs		Q8WVC0	B7Z4S1 P23193
PDB IDs		4M6T	1TFI 3NDQ
Enriched GO Terms of Interacting Partners?		Endodermal Cell Fate Commitment Stem Cell Maintenance Cell Fate Commitment Involved In Formation Of Primary Germ Layer Stem Cell Development Endodermal Cell Differentiation Wnt Signaling Pathway Transcription-coupled Nucleotide-excision Repair Stem Cell Differentiation Transcription, DNA-templated Positive Regulation Of Viral Transcription RNA Biosynthetic Process Endoderm Formation Regulation Of DNA-templated Transcription, Elongation Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process Regulation Of Chromosome Segregation Negative Regulation Of Myeloid Cell Differentiation Endoderm Development DNA-templated Transcription, Elongation Positive Regulation Of Macromolecule Biosynthetic Process Nucleotide-excision Repair Positive Regulation Of Gene Expression RNA Metabolic Process Regulation Of Fibroblast Proliferation Positive Regulation Of Cellular Biosynthetic Process Cell Differentiation Positive Regulation Of Metabolic Process Gene Expression Formation Of Primary Germ Layer Cellular Macromolecule Biosynthetic Process Cell Development Macromolecule Biosynthetic Process Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription, RNA-templated Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Cell Differentiation Positive Regulation Of Wnt Signaling Pathway Regulation Of Viral Process Neuron Migration Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development Glial Cell Fate Determination Oviduct Development	Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Transcription Elongation From RNA Polymerase II Promoter Endodermal Cell Fate Commitment Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription, Elongation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated MRNA Processing Cellular Nitrogen Compound Metabolic Process RNA Biosynthetic Process RNA Metabolic Process Histone H2B Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Cell Fate Commitment Involved In Formation Of Primary Germ Layer Positive Regulation Of Gene Expression MRNA Metabolic Process Gene Expression Positive Regulation Of Cellular Biosynthetic Process Endodermal Cell Differentiation RNA Processing Regulation Of Nitrogen Compound Metabolic Process Endoderm Formation Transcription Elongation From RNA Polymerase II Promoter Stem Cell Maintenance Regulation Of RNA Biosynthetic Process Histone Monoubiquitination Regulation Of RNA Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process DNA-templated Transcription, Elongation Negative Regulation Of Myeloid Cell Differentiation Endoderm Development MRNA Polyadenylation Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Histone Ubiquitination RNA Polyadenylation Negative Regulation Of Cell Differentiation Stem Cell Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Protein Monoubiquitination Regulation Of Histone Modification Wnt Signaling Pathway Formation Of Primary Germ Layer Positive Regulation Of Viral Transcription
Tagcloud ?		advantage aml comprehensively confers demethylase destabilization discovered h3k9me3 independence jmjd2c mediates mediator myelogenous occupancy oncogenes oncogenic overexpressed paf perturbed phenotypes prl prl3 proteomics repressive reverses screen silac sox2 sox4	arachnoid beforehand cdc25a cdk6 cluego cytoscape distinctive dysregulation helpful hub ifit ifit1 introduced mcm2 mcm7 mcode meningioma meningiomas meningothelial mined names neutralization ppi rbc sec31a seed subnetworks ube2e1 xrcc5
Tagcloud (Difference) ?		advantage aml comprehensively confers demethylase destabilization discovered h3k9me3 independence jmjd2c mediates mediator myelogenous occupancy oncogenes oncogenic overexpressed paf perturbed phenotypes prl prl3 proteomics repressive reverses screen silac sox2 sox4	arachnoid beforehand cdc25a cdk6 cluego cytoscape distinctive dysregulation helpful hub ifit ifit1 introduced mcm2 mcm7 mcode meningioma meningiomas meningothelial mined names neutralization ppi rbc sec31a seed subnetworks ube2e1 xrcc5
Tagcloud (Intersection) ?