SLC15A4 and GLP1R

Number of citations of the paper that reports this interaction (PMID 23864651)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		SLC15A4	GLP1R
Gene Name		solute carrier family 15 (oligopeptide transporter), member 4	glucagon-like peptide 1 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	L-histidine Transmembrane Transporter Activity Symporter Activity	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity
	Biological Process	Ion Transport Oligopeptide Transport Protein Transport Transmembrane Transport L-histidine Transmembrane Transport	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways		Transport of inorganic cations/anions and amino acids/oligopeptides Proton/oligonucleotide cotransporters SLC-mediated transmembrane transport	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS		Palmitic acid (16:0) plasma levels ( 23362303) Systemic lupus erythematosus ( 23273568 19838193)
Protein-Protein Interactions		1 interactors: GLP1R	41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13
Entrez ID		121260	2740
HPRD ID		11566	00677
Ensembl ID		ENSG00000139370	ENSG00000112164
Uniprot IDs		Q8N697	P43220
PDB IDs			3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		CAMP-mediated Signaling Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Positive Regulation Of Adenylate Cyclase Activity Cellular Response To Glucagon Stimulus Positive Regulation Of Lyase Activity Response To Glucagon Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Energy Reserve Metabolic Process Second-messenger-mediated Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Heart Contraction Cytosolic Calcium Ion Homeostasis Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Learning Or Memory Cognition Cellular Calcium Ion Homeostasis Energy Derivation By Oxidation Of Organic Compounds Calcium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Protein Secretion Cellular Metal Ion Homeostasis Generation Of Precursor Metabolites And Energy Cellular Cation Homeostasis Cellular Ion Homeostasis Single-organism Behavior Response To Peptide Hormone Cellular Response To Organonitrogen Compound Metal Ion Homeostasis Response To Peptide Cellular Chemical Homeostasis Ion Homeostasis Cellular Response To Hormone Stimulus Behavior Regulation Of Protein Transport Regulation Of Secretion Regulation Of Establishment Of Protein Localization	Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport
Tagcloud ?		bacterially cognate cytosol dipeptide egress endo endocytic endosomal endosomally endosomes internalized lumenal mdp microbial muramyl nlrs nod1 nod2 pathogens platforms ref refs ripk2 senses sensing sensors tlrs transporters	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Difference) ?		bacterially cognate cytosol dipeptide egress endo endocytic endosomal endosomally endosomes internalized lumenal mdp microbial muramyl nlrs nod1 nod2 pathogens platforms ref refs ripk2 senses sensing sensors tlrs transporters	2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Intersection) ?