SLC15A4

Description		solute carrier family 15 member 4
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GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Endosome Plasma Membrane Endosome Membrane Membrane Early Endosome Membrane Specific Granule Membrane Endolysosome Membrane
	Molecular Function	L-histidine Transmembrane Transporter Activity Protein Binding Symporter Activity Peptide:proton Symporter Activity Peptidoglycan Transmembrane Transporter Activity Transmembrane Transporter Activity Dipeptide Transmembrane Transporter Activity
	Biological Process	Immune System Process Monoatomic Ion Transport Oligopeptide Transport Protein Transport Histidine Transport Peptide Transport Peptidoglycan Transport Mast Cell Homeostasis Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 8 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Isotype Switching To IgG Isotypes Transmembrane Transport Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway L-histidine Transmembrane Export From Vacuole Dipeptide Import Across Plasma Membrane Proton Transmembrane Transport
Pathways		Proton/oligopeptide cotransporters Neutrophil degranulation SLC15A4:TASL-dependent IRF5 activation
Drugs
Diseases
GWAS		Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Cognitive decline rate in late mild cognitive impairment ( 26252872) Palmitic acid (16:0) levels ( 23362303) Periodontal disease related phenotype (PCT5) ( 26962152) Systemic lupus erythematosus ( 19838193 19838195 23273568 26502338 26663301 27399966 28714469 32771030 33272962)
Interacting Genes		3 interacting genes: DRD2 GLP1R GPR35
Entrez ID		121260
HPRD ID		11566
Ensembl ID		ENSG00000139370
Uniprot IDs		Q8N697
PDB IDs		8JZR 8JZS 8JZU 8JZX 8P6A 8QSK 8QSL 8QSM 8QSN 8WX3 8WX4 8WX5
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Activity Negative Regulation Of Blood Pressure Negative Regulation Of Synaptic Transmission, Glutamatergic Cognition Response To Histamine Regulation Of Synapse Structural Plasticity Dopamine Binding Regulation Of Renal Sodium Excretion Dopamine Neurotransmitter Receptor Activity Cerebral Cortex GABAergic Interneuron Migration Regulation Of Monoatomic Ion Transport Regulation Of Blood Circulation Learning Or Memory Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Regulation Of Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway G Protein-coupled Receptor Complex Catecholamine Uptake Dopamine Uptake Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go Adenohypophysis Development Negative Regulation Of Dephosphorylation Response To Inactivity Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Glial Cell-derived Neurotrophic Factor Production Negative Regulation Of Neuron Migration Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Hyaloid Vascular Plexus Regression Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Orbitofrontal Cortex Development G Protein-coupled Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Interneuron Migration From The Subpallium To The Cortex Branching Morphogenesis Of A Nerve Cell Surface Receptor Signaling Pathway Negative Regulation Of Dopamine Secretion Peristalsis Regulation Of Metal Ion Transport Positive Regulation Of Growth Hormone Secretion Positive Regulation Of Neurotransmitter Uptake Regulation Of Heart Contraction Regulation Of Dopamine Uptake Involved In Synaptic Transmission Heterotrimeric G-protein Binding Regulation Of Locomotion Involved In Locomotory Behavior Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Transport Positive Regulation Of Urine Volume Regulation Of Blood Pressure Behavioral Response To Ethanol
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