CLTA and HIP1

Number of citations of the paper that reports this interaction (PMID 11889126)
22

Data Source:
HPRD (in vitro)

		CLTA	HIP1
Gene Name		clathrin, light chain A	huntingtin interacting protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Clathrin Complex	Nucleus Cytoplasm Golgi Apparatus Cytoskeleton Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Molecular_function Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Clathrin Binding Protein Binding, Bridging Phosphatidylinositol Binding
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Membrane Organization	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Endocytosis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Cytoskeleton Organization Cell Differentiation Regulation Of Apoptotic Process Positive Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Apoptotic Signaling Pathway
Pathways		Retrograde neurotrophin signalling Axon guidance Gap junction degradation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling EGFR downregulation Formation of annular gap junctions Signalling by NGF Gap junction trafficking Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs
Diseases
GWAS			Alcoholism (12-month weekly alcohol consumption) ( 21529783)
Protein-Protein Interactions		8 interactors: CLTC EGFR HIP1 HIP1R HSPA8 MAP1LC3B RGS2 SYNJ1	22 interactors: AP2A1 AP2B1 APAF1 CASP3 CASP8 CASP9 CLTA CLTB CLTC DAZAP2 EIF6 FBXO25 HIP1R HTT IFT57 ITSN1 MAPK6 NECAP1 PFDN1 REL RPS10 TFAP2A
Entrez ID		1211	3092
HPRD ID		00351	03461
Ensembl ID		ENSG00000122705	ENSG00000127946
Uniprot IDs		C9J8P9 P09496	B4DK46 O00291
PDB IDs			2NO2 2QA7 3I00
Enriched GO Terms of Interacting Partners?		Membrane Organization Endocytosis Vesicle-mediated Transport Regulation Of Cellular Component Organization Positive Regulation Of Synaptic Vesicle Uncoating Alkanesulfonate Metabolic Process Negative Regulation Of Fibril Organization Synaptic Vesicle Uncoating Regulation Of Synaptic Vesicle Membrane Organization Regulation Of Phospholipase Activity Post-Golgi Vesicle-mediated Transport Positive Regulation Of Endocytosis Neurotransmitter Secretion Positive Regulation Of Synaptic Transmission Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Neurotransmitter Levels Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Fibril Organization Activation Of Phospholipase A2 Activity Neurotransmitter Transport Positive Regulation Of Transport Cellular Protein Complex Disassembly Positive Regulation Of Phospholipase A2 Activity Clathrin Coat Disassembly Regulation Of Endocytosis Protein Complex Disassembly Regulation Of Synaptic Vesicle Endocytosis Response To Cobalamin Response To UV-A Regulation Of Adrenergic Receptor Signaling Pathway Response To Hydroxyisoflavone Positive Regulation Of Cardiac Muscle Contraction Cell Differentiation Negative Regulation Of CAMP-mediated Signaling Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Phospholipase Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Synaptic Vesicle Priming Relaxation Of Vascular Smooth Muscle Learning Or Memory Golgi Vesicle Transport Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Catenin Import Into Nucleus Inositol Phosphate Dephosphorylation Relaxation Of Smooth Muscle Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Neurotrophin TRK Receptor Signaling Pathway Zymogen Activation Neurotrophin Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Endopeptidase Activity Regulation Of Neuron Death Positive Regulation Of Peptidase Activity Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Morphogenesis Of Embryonic Epithelium Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Death Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of ERBB Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Nervous System Development Endocytosis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Vesicle-mediated Transport Anatomical Structure Morphogenesis Protein Processing Regulation Of Neuron Apoptotic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Negative Regulation Of Hyaluronan Biosynthetic Process Intracellular Transport Establishment Of Localization In Cell Regulation Of Cell Death Neural Tube Formation Positive Regulation Of Proteolysis Embryonic Epithelial Tube Formation Epithelial Tube Formation Intracellular Protein Transport Cellular Response To Growth Factor Stimulus Response To Growth Factor Glial Cell Apoptotic Process Apoptotic Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Apoptotic Process ERBB Signaling Pathway Cellular Localization Tube Formation Protein Transport Programmed Cell Death
Tagcloud ?		anaphase cdc20 cdh1 chromosomes clathrin cltc concentrated diffusely fzr1 g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion	128a biomarker brains candidates canonical causal disruption downregulated dysregulation focused frontal hd htt huntingtin huntington intriguing lists micrornas mir mirna mirnas monkey monkeys neurodegenerative neurological panel primate symptomatic viable
Tagcloud (Difference) ?		anaphase cdc20 cdh1 chromosomes clathrin cltc concentrated diffusely fzr1 g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion	128a biomarker brains candidates canonical causal disruption downregulated dysregulation focused frontal hd htt huntingtin huntington intriguing lists micrornas mir mirna mirnas monkey monkeys neurodegenerative neurological panel primate symptomatic viable
Tagcloud (Intersection) ?