CLTA and SYNJ1

Number of citations of the paper that reports this interaction (PMID 12057195)
45

Data Source:
BioGRID (pull down)

		CLTA	SYNJ1
Gene Name		clathrin, light chain A	synaptojanin 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Clathrin Complex	Cytosol Membrane Coat
	Molecular Function	Molecular_function Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding	Nucleotide Binding RNA Binding Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Membrane Organization	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Neurotransmitter Transport Synaptic Vesicle Priming Synaptic Vesicle Uncoating Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Regulation Of Synaptic Vesicle Membrane Organization Positive Regulation Of Synaptic Vesicle Uncoating
Pathways		Retrograde neurotrophin signalling Axon guidance Gap junction degradation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling EGFR downregulation Formation of annular gap junctions Signalling by NGF Gap junction trafficking Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Synthesis of IP2, IP, and Ins in the cytosol Metabolism of lipids and lipoproteins Phospholipid metabolism Inositol phosphate metabolism PI Metabolism
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: CLTC EGFR HIP1 HIP1R HSPA8 MAP1LC3B RGS2 SYNJ1	23 interactors: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 GRB2 ITSN1 PACSIN1 PACSIN2 PACSIN3 PPP3CA SH3BP1 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SORBS2
Entrez ID		1211	8867
HPRD ID		00351	09182
Ensembl ID		ENSG00000122705	ENSG00000159082
Uniprot IDs		C9J8P9 P09496	B9EGN3 C9JFZ1 J3KPK1 J3KQV8 O43426 Q05CZ1
PDB IDs			1W80 2DNR 2VJ0
Enriched GO Terms of Interacting Partners?		Membrane Organization Endocytosis Vesicle-mediated Transport Regulation Of Cellular Component Organization Positive Regulation Of Synaptic Vesicle Uncoating Alkanesulfonate Metabolic Process Negative Regulation Of Fibril Organization Synaptic Vesicle Uncoating Regulation Of Synaptic Vesicle Membrane Organization Regulation Of Phospholipase Activity Post-Golgi Vesicle-mediated Transport Positive Regulation Of Endocytosis Neurotransmitter Secretion Positive Regulation Of Synaptic Transmission Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Neurotransmitter Levels Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Fibril Organization Activation Of Phospholipase A2 Activity Neurotransmitter Transport Positive Regulation Of Transport Cellular Protein Complex Disassembly Positive Regulation Of Phospholipase A2 Activity Clathrin Coat Disassembly Regulation Of Endocytosis Protein Complex Disassembly Regulation Of Synaptic Vesicle Endocytosis Response To Cobalamin Response To UV-A Regulation Of Adrenergic Receptor Signaling Pathway Response To Hydroxyisoflavone Positive Regulation Of Cardiac Muscle Contraction Cell Differentiation Negative Regulation Of CAMP-mediated Signaling Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Phospholipase Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Synaptic Vesicle Priming Relaxation Of Vascular Smooth Muscle Learning Or Memory Golgi Vesicle Transport Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Catenin Import Into Nucleus Inositol Phosphate Dephosphorylation Relaxation Of Smooth Muscle Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy	Endocytosis Vesicle-mediated Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Transport Neuron Projection Morphogenesis Cell-cell Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Axonogenesis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Neuron Projection Development Regulation Of Cellular Component Organization Axon Development Cell Projection Organization Membrane Organization Synaptic Transmission Cell Morphogenesis Involved In Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Chemotaxis Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Synaptic Vesicle Transport Locomotion Neuron Development Membrane Tubulation Cell Morphogenesis Involved In Differentiation Nervous System Development Cellular Localization Movement Of Cell Or Subcellular Component Neuron Differentiation Establishment Of Localization In Cell Generation Of Neurons Regulation Of Endocytosis Neurogenesis Regulation Of Vesicle-mediated Transport Establishment Of Vesicle Localization Vesicle Localization
Tagcloud ?		anaphase cdc20 cdh1 chromosomes clathrin cltc concentrated diffusely fzr1 g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion	aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj2 targetable xenografts
Tagcloud (Difference) ?		anaphase cdc20 cdh1 chromosomes clathrin cltc concentrated diffusely fzr1 g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion	aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj2 targetable xenografts
Tagcloud (Intersection) ?