CLTA and HIP1R

Number of citations of the paper that reports this interaction (PMID 15533940)
30

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		CLTA	HIP1R
Gene Name		clathrin, light chain A	huntingtin interacting protein 1 related
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Cytoplasmic Membrane-bounded Vesicle Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle Clathrin Complex	Cytoplasm Cytoskeleton Coated Pit Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding	Actin Binding Protein Binding Protein Binding, Bridging Phosphatidylinositol Binding
	Biological Process	Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Endocytosis Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Membrane Organization	Receptor-mediated Endocytosis Actin Cytoskeleton Organization
Pathways		Retrograde neurotrophin signalling Axon guidance Gap junction degradation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells Gap junction trafficking and regulation MHC class II antigen presentation EPH-Ephrin signaling EGFR downregulation Formation of annular gap junctions Signalling by NGF Gap junction trafficking Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS			Parkinson's disease ( 21292315)
Protein-Protein Interactions		8 interactors: CLTC EGFR HIP1 HIP1R HSPA8 MAP1LC3B RGS2 SYNJ1	8 interactors: ACTA1 CLTA CLTB CLTC CTTN DYNLL1 HIP1 HTT
Entrez ID		1211	9026
HPRD ID		00351	10412
Ensembl ID		ENSG00000122705	ENSG00000130787
Uniprot IDs		C9J8P9 P09496	B3KN98 B3KQW8 O75146 Q6NXG8
PDB IDs			1R0D
Enriched GO Terms of Interacting Partners?		Membrane Organization Endocytosis Vesicle-mediated Transport Regulation Of Cellular Component Organization Positive Regulation Of Synaptic Vesicle Uncoating Alkanesulfonate Metabolic Process Negative Regulation Of Fibril Organization Synaptic Vesicle Uncoating Regulation Of Synaptic Vesicle Membrane Organization Regulation Of Phospholipase Activity Post-Golgi Vesicle-mediated Transport Positive Regulation Of Endocytosis Neurotransmitter Secretion Positive Regulation Of Synaptic Transmission Activation Of Phospholipase A2 Activity By Calcium-mediated Signaling Astrocyte Activation Regulation Of Neurotransmitter Levels Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Fibril Organization Activation Of Phospholipase A2 Activity Neurotransmitter Transport Positive Regulation Of Transport Cellular Protein Complex Disassembly Positive Regulation Of Phospholipase A2 Activity Clathrin Coat Disassembly Regulation Of Endocytosis Protein Complex Disassembly Regulation Of Synaptic Vesicle Endocytosis Response To Cobalamin Response To UV-A Regulation Of Adrenergic Receptor Signaling Pathway Response To Hydroxyisoflavone Positive Regulation Of Cardiac Muscle Contraction Cell Differentiation Negative Regulation Of CAMP-mediated Signaling Regulation Of Synaptic Vesicle Recycling Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Phospholipase Activity Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Synaptic Vesicle Priming Relaxation Of Vascular Smooth Muscle Learning Or Memory Golgi Vesicle Transport Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Catenin Import Into Nucleus Inositol Phosphate Dephosphorylation Relaxation Of Smooth Muscle Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy	Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Intracellular Protein Transport Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cytoskeleton Organization Actin Cytoskeleton Organization Cellular Protein Localization Actin Filament-based Process Protein Transport Endocytosis Establishment Of Protein Localization Antigen Processing And Presentation Of Peptide Antigen Intracellular Transport Golgi Vesicle Transport Antigen Processing And Presentation Membrane Organization Transport Organelle Organization Protein Localization Establishment Of Localization In Cell Cell Differentiation Developmental Process Neural Plate Formation Post-Golgi Vesicle-mediated Transport Cellular Localization Anatomical Structure Morphogenesis Serotonin Uptake Skeletal Muscle Fiber Adaptation Lactate Biosynthetic Process From Pyruvate Regulation Of Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Movement Of Cell Or Subcellular Component Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Hyaluronan Biosynthetic Process Regulation Of Protein Phosphatase Type 2A Activity Regulation Of Cell Death Mitotic Cell Cycle Process Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Positive Regulation Of Transport Mitotic Cell Cycle Lactate Biosynthetic Process Cell Development Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Paraxial Mesoderm Formation Cellular Component Assembly Quinolinate Metabolic Process
Tagcloud ?		anaphase cdc20 cdh1 chromosomes clathrin cltc concentrated diffusely fzr1 g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion	avoided balanced ccdc62 desipramine dextromethorphan escitalopram favorably fluoxetine gba gdnf haloperidol investigative lithium mapt neurogenesis neuroinflammation neuroprotective pathobiological pathobiology pramipexole priorities proteasomal psychotropics replicated rns safest salutary trophic valproate
Tagcloud (Difference) ?		anaphase cdc20 cdh1 chromosomes clathrin cltc concentrated diffusely fzr1 g2 gst interactor kinetochore localize mad2b mad2l2 misaligned mitotic p11 prcc pull q21 rccs redistribution shuttle spindle tfe3 trimeric triskelion	avoided balanced ccdc62 desipramine dextromethorphan escitalopram favorably fluoxetine gba gdnf haloperidol investigative lithium mapt neurogenesis neuroinflammation neuroprotective pathobiological pathobiology pramipexole priorities proteasomal psychotropics replicated rns safest salutary trophic valproate
Tagcloud (Intersection) ?