CLTA and HIP1R

Number of citations of the paper that reports this interaction (PubMedID 15533940)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		CLTA	HIP1R
Description		clathrin light chain A	huntingtin interacting protein 1 related
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GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Golgi Apparatus Spindle Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Membrane Clathrin Coat Clathrin Vesicle Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Endolysosome Membrane Clathrin-coated Endocytic Vesicle Clathrin Complex Presynaptic Endocytic Zone Membrane Postsynaptic Endocytic Zone	Cytoplasm Mitochondrion Cytosol Cytoskeleton Plasma Membrane Clathrin-coated Pit Cell Cortex Endomembrane System Postsynaptic Density Membrane Apical Plasma Membrane Clathrin-coated Vesicle Clathrin-coated Vesicle Membrane Cortical Actin Cytoskeleton Cytoplasmic Vesicle Ruffle Membrane Dendrite Cytoplasm Neuronal Cell Body Dendritic Spine Perinuclear Region Of Cytoplasm Synaptic Membrane Postsynapse Postsynaptic Endocytic Zone Glutamatergic Synapse
	Molecular Function	Structural Molecule Activity Protein Binding Clathrin Heavy Chain Binding Peptide Binding Protein-containing Complex Binding GTPase Binding	Actin Binding Protein Binding Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding SH3 Domain Binding Clathrin Binding Clathrin Light Chain Binding Phosphatidylinositol Binding Clathrin Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Phosphatidylinositol-3,4-bisphosphate Binding Protein Heterodimerization Activity Actin Filament Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Intracellular Protein Transport Endocytosis Vesicle-mediated Transport Clathrin Coat Assembly Synaptic Vesicle Endocytosis Cell Division Clathrin-dependent Endocytosis	Endocytosis Receptor-mediated Endocytosis Actin Filament Organization Regulation Of Endocytosis Negative Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Clathrin Coat Assembly Protein Stabilization Positive Regulation Of Transport Positive Regulation Of Cellular Component Organization Digestive System Development Regulation Of Gastric Acid Secretion Membrane Organization Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Postsynapse Organization Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Clathrin Coat Assembly Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance	Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bisphosphonate-associated atypical femoral fracture ( 31006051)	A body shape index ( 34021172) Atrial fibrillation ( 29892015 30061737) Body mass index ( 29273807) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Mean platelet volume ( 32888494) Parkinson's disease ( 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Schizophrenia ( 30285260) Tourette syndrome ( 30818990) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: CEBPA CLTC EGFR HIP1 HIP1R HSPA8 MAP1LC3B RGS2 SHANK3 SYNJ1	13 interacting genes: ACTA1 ACTB CLTA CLTB CLTC CTTN DYNLL1 EPN1 HIP1 HTT TFIP11 TRIM27 UBC
Entrez ID		1211	9026
HPRD ID		00351	10412
Ensembl ID		ENSG00000122705	ENSG00000130787
Uniprot IDs		C9J8P9 P09496	B3KQW8 B4DPL0 O75146
PDB IDs		6E5N	1R0D
Enriched GO Terms of Interacting Partners?		Vesicle Uncoating Clathrin Coat Disassembly Clathrin Light Chain Binding Clathrin Coat Assembly Protein-containing Complex Disassembly Protein Depolymerization Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Clathrin Coat Of Coated Pit Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of ERBB Signaling Pathway Clathrin-coated Vesicle Learning Or Memory Regulation Of Cellular Component Organization Cognition Clathrin Adaptor Activity Phospholipid Binding Protein-containing Complex Organization Embryonic Placenta Development Endocytosis Phosphatidylinositol-3,4-bisphosphate Binding Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Supramolecular Fiber Organization Phosphatidylinositol-3,5-bisphosphate Binding Brown Fat Cell Differentiation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Component Assembly Positive Regulation Of ERBB Signaling Pathway Clathrin-coated Vesicle Membrane Clathrin Binding Actin Filament Binding Postsynapse Organization Positive Regulation Of Cellular Component Organization Import Into Cell RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Multivesicular Body, Internal Vesicle Lumen Endomembrane System Cortical Actin Cytoskeleton Chaperone-mediated Autophagy Translocation Complex Disassembly Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Positive Regulation Of Endosome Organization Positive Regulation Of Clathrin Coat Assembly Autophagy Synaptic Membrane Cytosol Ubiquitin Protein Ligase Binding Cytoplasm Clathrin-coated Endocytic Vesicle Membrane Clathrin-coated Pit	Cytosol Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin-coated Pit Clathrin Coat Of Coated Pit Clathrin Vesicle Coat Vesicle-mediated Transport Presynaptic Endocytic Zone Membrane Clathrin Coat Assembly Clathrin-coated Endocytic Vesicle Cytoplasm Endocytosis Clathrin-dependent Endocytosis Intracellular Transport Nitric-oxide Synthase Regulator Activity Receptor-mediated Endocytosis Import Into Cell Cytoplasmic Vesicle Membrane Clathrin Complex Clathrin Light Chain Binding Postsynaptic Actin Cytoskeleton Clathrin Heavy Chain Binding Profilin Binding Cytoskeleton Regulation Of Cellular Component Organization Clathrin-coated Vesicle Cellular Localization Establishment Of Localization In Cell Actin Filament Regulation Of Organelle Organization Neuron Projection Morphogenesis Structural Constituent Of Cytoskeleton Cell Projection Morphogenesis Endolysosome Membrane Intracellular Protein Transport Developmental Process Cortical Cytoskeleton Peptide Binding Plasma Membrane Bounded Cell Projection Assembly Face Morphogenesis Cell Projection Assembly Axonogenesis Protein Transport Dynein Intermediate Chain Binding Clathrin Binding Cell Projection Organization Lamellipodium Anatomical Structure Homeostasis Tissue Homeostasis Substantia Nigra Development
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