ZRSR2 and SPATS2L

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		ZRSR2	SPATS2L
Description		zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2	spermatogenesis associated serine rich 2 like
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex U2AF Complex Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding Zinc Ion Binding Pre-mRNA 3'-splice Site Binding Identical Protein Binding Metal Ion Binding	RNA Binding
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing
Pathways		mRNA Splicing - Minor Pathway
Drugs
Diseases
GWAS			Alcohol dependence or chronic alcoholic pancreatitis or alcohol-related liver cirrhosis ( 28714907) Asthma (bronchodilator response) ( 22792082) Atrial fibrillation ( 30061737 29892015) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 33169155) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting plasma glucose ( 32682390) FEV1 ( 30804560) Household income (MTAG) ( 31844048) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Pelvic organ prolapse ( 26545240) QT interval ( 24952745) QT interval (sulfonylurea treatment interaction) ( 27958378) Reaction time ( 27046643 29844566) Schizophrenia ( 23974872 30285260 29483656 28991256) Schizophrenia (MTAG) ( 32107650) Sleep duration ( 30846698) Systolic blood pressure ( 30224653) Urate levels in lean individuals ( 25811787) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		23 interacting genes: APP CCNL1 CLK1 CLK2 DSCR9 DVL3 KHDC4 LUC7L2 PRPF6 REP15 RPS27L SDCBP2 SPATS2L SRPK2 SRRM4 SRSF1 SRSF2 SRSF5 SSX2IP TEPSIN TNFAIP8L1 U2AF1 U2AF2	5 interacting genes: CSNK2A1 EEF1A1 OGT RBFOX2 ZRSR2
Entrez ID		8233	26010
HPRD ID		02068	10916
Ensembl ID		ENSG00000169249	ENSG00000196141
Uniprot IDs		A0A8I5KSD0 Q15696	B8ZZZ7 Q9NUQ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of RNA Splicing Nuclear Speck Protein-RNA Complex Assembly RNA Splicing MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing MRNA Metabolic Process MRNA Splice Site Recognition RNA Binding RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome Protein-containing Complex Assembly Spliceosomal Complex Regulation Of MRNA Metabolic Process Protein-containing Complex Organization RNA Splicing, Via Transesterification Reactions MRNA Binding RS Domain Binding Positive Regulation Of RNA Splicing Pre-mRNA 3'-splice Site Binding U2AF Complex Spliceosomal Complex Assembly RNA Metabolic Process Protein Kinase B Binding Cellular Component Assembly MRNA Splicing, Via Spliceosome Nucleus Catalytic Step 2 Spliceosome U2-type Prespliceosome Protein Serine/threonine/tyrosine Kinase Activity Liver Regeneration Neuron Maturation Nucleoplasm Nucleic Acid Binding Nucleic Acid Metabolic Process Frizzled Binding Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Glucose Transporter Complex Coated Vesicle Membrane	Sin3-type Complex MRNA Metabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Translational Initiation Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process RNA Splicing Negative Regulation Of Proteolysis Involved In Protein Catabolic Process MRNA Processing Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein Localization To Vacuole Regulation Of Translational Initiation RNA Metabolic Process Macromolecule Metabolic Process Negative Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Protein O-acetylglucosaminyltransferase Activity Protein Folding Negative Regulation Of Translation Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Aggrephagy Macroautophagy Eukaryotic Translation Elongation Factor 1 Complex MRNA Splicing, Via Spliceosome Spliceosomal Complex Pre-mRNA 3'-splice Site Binding U2AF Complex RNA Processing RNA Splicing, Via Transesterification Reactions Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Nucleic Acid Metabolic Process Carbon Catabolite Regulation Of Transcription Regulation Of Chaperone-mediated Autophagy Nucleoplasm Regulation Of Transcription By Glucose Rhythmic Process Host-mediated Activation Of Viral Genome Replication Double-strand Break Repair Via Classical Nonhomologous End Joining Membraneless Organelle Assembly Host-mediated Perturbation Of Viral Genome Replication NSL Complex
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