PRDX5

Description		peroxiredoxin 5
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	RNA Polymerase III Transcription Regulatory Region Sequence-specific DNA Binding Peroxidase Activity Signaling Receptor Binding Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Peroxynitrite Reductase Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Inflammatory Response Response To Oxidative Stress Negative Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Cell Redox Homeostasis Negative Regulation Of Oxidoreductase Activity Regulation Of Apoptosis Involved In Tissue Homeostasis Cellular Oxidant Detoxification Reactive Nitrogen Species Metabolic Process
Pathways
Drugs		Auranofin Diminazene
Diseases
GWAS		Alopecia areata ( 20596022 25608926) Crohn's disease ( 21102463 28067908) Multiple sclerosis ( 24076602 31604244) Psoriasis ( 23143594) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Psoriasis vulgaris ( 26626624) Sarcoidosis ( 22837380) Vitiligo ( 27723757)
Interacting Genes		10 interacting genes: APP CCDC90B CDKN2D CLK1 ERBB2 ERBB3 ERBB4 NUFIP2 PEX5 SMCP
Entrez ID		25824
HPRD ID		05958
Ensembl ID		ENSG00000126432
Uniprot IDs		P30044
PDB IDs		1H4O 1HD2 1OC3 1URM 2VL2 2VL3 2VL9 3MNG 4K7I 4K7N 4K7O 4MMM
Enriched GO Terms of Interacting Partners?		ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Protein Tyrosine Kinase Activity Neuregulin Receptor Activity Receptor Complex ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Glial Cell Development Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Growth ERBB Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Neuron Differentiation Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of MAPK Cascade Peripheral Nervous System Development Protein Kinase Activity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Forebrain Neuron Differentiation Regulation Of MAPK Cascade Synapse Organization Kinase Activity Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Growth Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Basolateral Plasma Membrane Heart Development Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Regulation Of ERK1 And ERK2 Cascade Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Localization To Synapse Establishment Of Planar Polarity Involved In Nephron Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
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