PRDX5 and CCDC90B

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRDX5	CCDC90B
Gene Name		peroxiredoxin 5	coiled-coil domain containing 90B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Mitochondrion Integral Component Of Membrane
	Molecular Function	RNA Polymerase III Regulatory Region DNA Binding Peroxidase Activity Receptor Binding Antioxidant Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Dimerization Activity Peroxiredoxin Activity Peroxynitrite Reductase Activity
	Biological Process	Response To Reactive Oxygen Species Inflammatory Response Response To Oxidative Stress Negative Regulation Of Transcription From RNA Polymerase III Promoter Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Reactive Oxygen Species Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Oxidoreductase Activity Oxidation-reduction Process Regulation Of Apoptosis Involved In Tissue Homeostasis NADPH Oxidation Reactive Nitrogen Species Metabolic Process
Pathways
Drugs		Auranofin Diminazene Benzoic Acid
Diseases
GWAS		Alopecia areata ( 20596022) Crohn's disease ( 21102463) Sarcoidosis ( 22837380)
Protein-Protein Interactions		3 interactors: APP CCDC90B PEX5	29 interactors: AGR2 ANXA7 ARL15 BTBD2 CDKN2B CDKN2C DLEU1 DNM2 EIF2S2 FXYD6 KDM1A LAMTOR1 NACA NIPSNAP3A PAFAH1B3 PCDHA4 PIN1 PNP PRDX5 PSMD11 RGL2 RNF10 SAT1 SDHAF2 SERPINB9 SMN1 TAC3 TK1 TSC22D1
Entrez ID		25824	60492
HPRD ID		05958	14378
Ensembl ID		ENSG00000126432	ENSG00000137500
Uniprot IDs		P30044	B3KP87 Q9GZT6
PDB IDs		1H4O 1HD2 1OC3 1URM 2VL2 2VL3 2VL9 3MNG
Enriched GO Terms of Interacting Partners?		Regulation Of Multicellular Organism Growth Neuromuscular Process Regulation Of Developmental Growth Negative Regulation Of Protein Homotetramerization Synaptic Growth At Neuromuscular Junction Protein Import Into Peroxisome Matrix, Translocation Collateral Sprouting In Absence Of Injury Protein Import Into Peroxisome Matrix, Docking Forebrain Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Homooligomerization Axon Choice Point Recognition Protein Import Into Peroxisome Membrane Protein To Membrane Docking Peroxisomal Membrane Transport Regulation Of Growth Neuron Remodeling Negative Regulation Of Protein Oligomerization Brain Development Protein Import Into Peroxisome Matrix Head Development Cellular Copper Ion Homeostasis Central Nervous System Development Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Establishment Of Protein Localization To Peroxisome Protein Targeting To Peroxisome Very Long-chain Fatty Acid Metabolic Process Neuron Differentiation Cerebral Cortex Neuron Differentiation Regulation Of Protein Oligomerization Neurological System Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Mating Behavior Locomotion Endoplasmic Reticulum Calcium Ion Homeostasis Lipid Metabolic Process RNA Polyadenylation Neuron Recognition Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Endoplasmic Reticulum Organization Fatty Acid Beta-oxidation Peroxisome Organization Ionotropic Glutamate Receptor Signaling Pathway Regulation Of G2/M Transition Of Mitotic Cell Cycle	Regulation Of Cell Proliferation Developmental Process System Development Anatomical Structure Development Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Cellular Protein Metabolic Process Nucleoside Metabolic Process Negative Regulation Of Protein Metabolic Process Nucleotide Metabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Negative Regulation Of Cell Death Multicellular Organismal Development Reactive Nitrogen Species Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Regulation Of Catalytic Activity Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Cell Differentiation Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development Inosine Catabolic Process Regulation Of Apoptosis Involved In Tissue Homeostasis Regulation Of Primitive Erythrocyte Differentiation Nicotinamide Riboside Catabolic Process Fetal Process Involved In Parturition Mitochondrial Electron Transport, Succinate To Ubiquinone NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Membrane Tubulation Mucus Secretion Spermidine Acetylation Skeletal Muscle Cell Proliferation Interleukin-2 Secretion Urate Biosynthetic Process Purine Nucleoside Metabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Cellular Nitrogen Compound Metabolic Process Regulation Of Oxidoreductase Activity Endosome Localization Lung Goblet Cell Differentiation Protein-FAD Linkage Regulation Of Cholesterol Import Putrescine Catabolic Process Positive Regulation Of Skeletal Muscle Tissue Growth Response To Stimulus
Tagcloud ?		accelerates autoreactive cba draining gpx2 gpx4 gpx7 h2 imbalances immunoregulatory iodide isat looked microscopically nai peroxidases peroxiredoxins plausible prdx1 prdx2 sat thioredoxin thyrocytes thyroiditis txn1 ucp2 ucp3 uncoupling upregulates
Tagcloud (Difference) ?		accelerates autoreactive cba draining gpx2 gpx4 gpx7 h2 imbalances immunoregulatory iodide isat looked microscopically nai peroxidases peroxiredoxins plausible prdx1 prdx2 sat thioredoxin thyrocytes thyroiditis txn1 ucp2 ucp3 uncoupling upregulates
Tagcloud (Intersection) ?