PRDX5 and SMCP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PRDX5	SMCP
Description		peroxiredoxin 5	sperm mitochondria associated cysteine rich protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Peroxisome Peroxisomal Matrix Cytosol Cytoplasmic Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Mitochondrion Membrane Mitochondrial Membrane
	Molecular Function	RNA Polymerase III Transcription Regulatory Region Sequence-specific DNA Binding Peroxidase Activity Signaling Receptor Binding Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Peroxynitrite Reductase Activity Thioredoxin-dependent Peroxiredoxin Activity	Protein Binding
	Biological Process	Inflammatory Response Response To Oxidative Stress Negative Regulation Of Transcription By RNA Polymerase III Positive Regulation Of Collagen Biosynthetic Process Cellular Response To Oxidative Stress Cellular Response To Reactive Oxygen Species Hydrogen Peroxide Catabolic Process Negative Regulation Of Apoptotic Process Cell Redox Homeostasis Negative Regulation Of Oxidoreductase Activity Regulation Of Apoptosis Involved In Tissue Homeostasis Cellular Oxidant Detoxification Reactive Nitrogen Species Metabolic Process	Single Fertilization Penetration Of Zona Pellucida Flagellated Sperm Motility
Pathways
Drugs		Auranofin Diminazene
Diseases
GWAS		Alopecia areata ( 20596022 25608926) Crohn's disease ( 21102463 28067908) Multiple sclerosis ( 24076602 31604244) Psoriasis ( 23143594) Psoriasis or type 2 diabetes (trans-disease meta-analysis) ( 33385400) Psoriasis vulgaris ( 26626624) Sarcoidosis ( 22837380) Vitiligo ( 27723757)	Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		10 interacting genes: APP CCDC90B CDKN2D CLK1 ERBB2 ERBB3 ERBB4 NUFIP2 PEX5 SMCP	78 interacting genes: ALPP C14orf119 CALCOCO2 CGB3 CGB5 CGB8 CTAG2 CYSRT1 DYNLL1 DYNLL2 GOLGA2 GRN GUCD1 HOXA1 IGFBP6 KRT31 KRT34 KRTAP1-1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-3 KRTAP12-4 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP4-7 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1D LCE1E LCE1F LCE2C LCE2D LCE3A LCE3B LCE4A LCE5A MACO1 MT1B MT1M NBPF19 NOTCH2NLA PCSK5 PLEKHG4 PLSCR1 PLSCR3 PPP1R27 PRDX5 RGS17 SLC39A7 SPRY1 TCF4 TRIM42 UBL5 VASN
Entrez ID		25824	4184
HPRD ID		05958	03093
Ensembl ID		ENSG00000126432	ENSG00000163206
Uniprot IDs		P30044	P49901 Q5T7P5
PDB IDs		1H4O 1HD2 1OC3 1URM 2VL2 2VL3 2VL9 3MNG 4K7I 4K7N 4K7O 4MMM
Enriched GO Terms of Interacting Partners?		ERBB3:ERBB2 Complex ERBB2 Signaling Pathway Protein Tyrosine Kinase Activity Neuregulin Receptor Activity Receptor Complex ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Glial Cell Development Basal Plasma Membrane Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Growth ERBB Signaling Pathway ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Neuron Differentiation Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of MAPK Cascade Peripheral Nervous System Development Protein Kinase Activity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Forebrain Neuron Differentiation Regulation Of MAPK Cascade Synapse Organization Kinase Activity Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Activity Positive Regulation Of Growth Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor Receptor Localization To Synapse Basolateral Plasma Membrane Heart Development Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of Calcium-mediated Signaling Regulation Of ERK1 And ERK2 Cascade Amylin Binding Positive Regulation Of Toll Signaling Pathway Cellular Response To Growth Factor Stimulus Protein Localization To Synapse Establishment Of Planar Polarity Involved In Nephron Morphogenesis Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction	Intermediate Filament Keratin Filament Epidermis Development Keratinization Hair Cycle Tissue Development Identical Protein Binding Cytosol Lead Ion Binding Mercury Ion Binding Intracellular Zinc Ion Homeostasis
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