TRIM6 and TRIM5

Number of citations of the paper that reports this interaction (PubMedID 11331580)
63

Data Source:
HPRD (two hybrid)

		TRIM6	TRIM5
Description		tripartite motif containing 6	tripartite motif containing 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	P-body Nucleus Cytoplasm Cytosol Omegasome
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity DNA-binding Transcription Factor Binding Protein Tyrosine Kinase Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Pattern Recognition Receptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Response To Lipopolysaccharide Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of DNA-templated Transcription Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Cellular Response To Virus Antiviral Innate Immune Response Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Stem Cell Differentiation	Activation Of Innate Immune Response Immune System Process Autophagy Regulation Of Gene Expression Protein Ubiquitination Regulation Of Lipopolysaccharide-mediated Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Host-mediated Suppression Of Symbiont Invasion Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Protein K63-linked Ubiquitination Regulation Of Primary Metabolic Process
Pathways		Interferon gamma signaling	Interferon gamma signaling
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Malaria ( 31844061)	Alanine aminotransferase levels ( 33547301) Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Coronary artery disease ( 29212778 33020668) DNA methylation (variation) ( 23725790) HDL cholesterol levels ( 32203549) LDL cholesterol levels ( 32203549) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Low density lipoprotein cholesterol levels ( 32154731) Malaria ( 31844061) Mean platelet volume ( 32888494 27863252) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Myocardial infarction ( 33532862) Platelet count ( 32888494 29403010) Serum alkaline phosphatase levels ( 33339817 29403010 33547301) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485)
Interacting Genes		6 interacting genes: LGALS3 LGALS8 MYC RIGI TRIM5 UBE2K	49 interacting genes: BTBD1 BTBD2 CFTR DSCR9 EHHADH EWSR1 ITSN1 LGALS8 LZTR1 MKRN3 MNAT1 MPP7 MTURN NTAQ1 OTUB2 OTUD6A PCBD1 PIAS1 PRKCG PSMC2 RUNX1 SGTA TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 TSGA10IP UBASH3A UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 UBE2W USP15 USP2 USP21 USP39 USP5 YES1
Entrez ID		117854	85363
HPRD ID		12123	07004
Ensembl ID		ENSG00000121236	ENSG00000132256
Uniprot IDs		Q9C030	A0A804HHS7 Q9C035
PDB IDs			2ECV 2YRG
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Positive Regulation Of Immune System Process NK T Cell Activation Positive Regulation Of Innate Immune Response Ubiquitin Protein Ligase Binding Immune System Process Pattern Recognition Receptor Activity Regulation Of Immune Response Regulation Of Lymphocyte Apoptotic Process Regulation Of Innate Immune Response Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Defense Response Response To Other Organism Lymphocyte Activation Response To Virus Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Response To External Biotic Stimulus Alpha-beta T Cell Activation Disaccharide Binding Leukocyte Activation Negative Regulation Of Immunological Synapse Formation Myc-Max Complex Regulation Of Acinar Cell Proliferation Omegasome Negative Regulation Of NK T Cell Activation Innate Immune Response Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Lymphatic Endothelial Cell Migration NK T Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of B Cell Apoptotic Process Detection Of Virus Defense Response To Symbiont Defense Response To Other Organism Carbohydrate Binding Regulation Of Defense Response Catabolic Process Positive Regulation Of Dendritic Cell Differentiation Receptor Ligand Inhibitor Activity IgE Binding Plasma Cell Differentiation Negative Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Monocyte Differentiation Regulation Of Type III Interferon Production	Post-translational Protein Modification Protein Modification Process Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein Metabolic Process Proteolysis Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Cysteine-type Deubiquitinase Activity Protein Deubiquitination Proteolysis Involved In Protein Catabolic Process Macromolecule Metabolic Process Protein Modification By Small Protein Removal Modification-dependent Protein Catabolic Process UBC13-MMS2 Complex Regulation Of Post-translational Protein Modification Protein K63-linked Ubiquitination Ubiquitin Conjugating Enzyme Complex Cysteine-type Peptidase Activity Transferase Activity Macromolecule Catabolic Process Positive Regulation Of Protein Polyubiquitination Nucleus Positive Regulation Of Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Activity Free Ubiquitin Chain Polymerization Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Protein K63-linked Ubiquitination Regulation Of Protein Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of Protein Modification Process Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Post-translational Protein Modification Regulation Of Protein Metabolic Process Protein K11-linked Deubiquitination Protein K11-linked Ubiquitination Proteasomal Protein Catabolic Process Regulation Of Protein K63-linked Ubiquitination Error-free Postreplication DNA Repair Positive Regulation Of Protein Modification Process Ubiquitin Binding Catabolic Process Positive Regulation Of Protein Ubiquitination Response To Virus Suppression Of Viral Release By Host Cytosol
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