TRIM6 and TRIM5

Number of citations of the paper that reports this interaction (PMID 11331580)
291

Data Source:
HPRD (two hybrid)

		TRIM6	TRIM5
Gene Name		tripartite motif containing 6	tripartite motif containing 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Cytoplasmic MRNA Processing Body Cytoplasm Cytosol
	Molecular Function	Molecular_function Zinc Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Signaling Pattern Recognition Receptor Activity Ligase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Trimerization	Activation Of Innate Immune Response Pattern Recognition Receptor Signaling Pathway Viral Process Cytokine-mediated Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Protein Trimerization Protein K63-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS			DNA methylation (variation) ( 23725790)
Protein-Protein Interactions		2 interactors: MYC TRIM5	35 interactors: BTBD1 BTBD2 EWSR1 LZTR1 MKRN3 MNAT1 OTUB2 OTUD6A PCBD1 PRKCG PSMC2 SUMO1 TNFAIP3 TRIM21 TRIM32 TRIM34 TRIM35 TRIM6 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2H UBE2K UBE2N UBE2U UBE2V1 UBE2V2 USP15 USP2 USP21 USP39 USP5
Entrez ID		117854	85363
HPRD ID		12123	07004
Ensembl ID		ENSG00000121236	ENSG00000132256
Uniprot IDs		Q9C030	Q9C035
PDB IDs			2ECV 2YRG
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Fibroblast Apoptotic Process Negative Regulation Of Monocyte Differentiation Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of MAPK Cascade Regulation Of Monocyte Differentiation Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Viral Entry Into Host Cell Regulation Of Telomere Maintenance Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of DNA Biosynthetic Process Regulation Of Viral Entry Into Host Cell Regulation Of Viral Release From Host Cell Oxygen Transport Protein K63-linked Ubiquitination Protein Trimerization Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Fibroblast Proliferation Regulation Of Immune System Process Regulation Of Phosphorylation Positive Regulation Of Kidney Development Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of DNA Biosynthetic Process Regulation Of Phosphorus Metabolic Process Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Myeloid Leukocyte Differentiation Response To Gamma Radiation Cellular Response To Drug Cellular Response To UV Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Fibroblast Proliferation Regulation Of Intracellular Signal Transduction Positive Regulation Of Response To DNA Damage Stimulus Ureteric Bud Morphogenesis Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Viral Process Cellular Response To Organic Substance Negative Regulation Of Cell Division Nephron Morphogenesis Renal Tubule Morphogenesis Cellular Iron Ion Homeostasis Negative Regulation Of Myeloid Cell Differentiation Cellular Response To Light Stimulus Canonical Wnt Signaling Pathway Regulation Of Fibroblast Proliferation Renal Tubule Development Kidney Morphogenesis Regulation Of Myeloid Leukocyte Differentiation Regulation Of Stem Cell Proliferation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Protein Polyubiquitination Protein Modification By Small Protein Conjugation Protein Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Macromolecule Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Protein Metabolic Process Proteolysis Protein K48-linked Ubiquitination Regulation Of Proteasomal Protein Catabolic Process Catabolic Process Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Proteasomal Protein Catabolic Process Regulation Of Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Positive Regulation Of Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Activation Of Innate Immune Response Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Innate Immune Response Protein Deubiquitination Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Protein Modification By Small Protein Removal Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Defense Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Response To Stress Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteolysis Protein K48-linked Deubiquitination Regulation Of Type I Interferon Production Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Protein Ubiquitination Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		antiviral attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 tripartite ube2k ubiquitin unanchored unrecognized	antiretroviral antiviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trims tripartite ulk1
Tagcloud (Difference) ?		attributes breadth chains conjugase cooperated demands e3 elicits elusive epsilon hundreds identifies ifn ikkepsilon interacted interferons isg isgs k48 ligase polyubiquitin stat1 ube2k ubiquitin unanchored unrecognized	antiretroviral ascribed assemble atg8 autophagic autophagy becn1 cargo constitutes defines destruction establishes exemplified explains hitherto machinery nucleate platforms preparation recognizes regulators reminiscent restriction trims ulk1
Tagcloud (Intersection) ?		antiviral tripartite