TRIM6

Description		tripartite motif containing 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity DNA-binding Transcription Factor Binding Protein Tyrosine Kinase Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Cytokine Production Involved In Immune Response Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Response To Lipopolysaccharide Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Negative Regulation Of Viral Genome Replication Innate Immune Response Negative Regulation Of DNA-templated Transcription Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Protein K48-linked Ubiquitination Regulation Of Primary Metabolic Process Cellular Response To Virus Antiviral Innate Immune Response Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Stem Cell Differentiation
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Malaria ( 31844061)
Interacting Genes		6 interacting genes: LGALS3 LGALS8 MYC RIGI TRIM5 UBE2K
Entrez ID		117854
HPRD ID		12123
Ensembl ID		ENSG00000121236
Uniprot IDs		Q9C030
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Immune System Process Positive Regulation Of Immune System Process NK T Cell Activation Positive Regulation Of Innate Immune Response Ubiquitin Protein Ligase Binding Immune System Process Pattern Recognition Receptor Activity Regulation Of Immune Response Regulation Of Lymphocyte Apoptotic Process Regulation Of Innate Immune Response Positive Regulation Of Response To Cytokine Stimulus Positive Regulation Of Defense Response Response To Other Organism Lymphocyte Activation Response To Virus Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Response To External Biotic Stimulus Alpha-beta T Cell Activation Disaccharide Binding Leukocyte Activation Negative Regulation Of Immunological Synapse Formation Myc-Max Complex Regulation Of Acinar Cell Proliferation Omegasome Negative Regulation Of NK T Cell Activation Innate Immune Response Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Lymphatic Endothelial Cell Migration NK T Cell Proliferation Positive Regulation Of Immune Response Positive Regulation Of Multicellular Organismal Process Positive Regulation Of B Cell Apoptotic Process Detection Of Virus Defense Response To Symbiont Defense Response To Other Organism Carbohydrate Binding Regulation Of Defense Response Catabolic Process Positive Regulation Of Dendritic Cell Differentiation Receptor Ligand Inhibitor Activity IgE Binding Plasma Cell Differentiation Negative Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Transcription Initiation By RNA Polymerase II Negative Regulation Of Monocyte Differentiation Regulation Of Type III Interferon Production
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