KCTD12 and GABBR2

Number of citations of the paper that reports this interaction (PMID 23996491)
1

Data Source:
BioGRID (pull down)

		KCTD12	GABBR2
Gene Name		potassium channel tetramerization domain containing 12	gamma-aminobutyric acid (GABA) B receptor, 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cell Junction Presynaptic Membrane Receptor Complex Postsynaptic Membrane Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction G-protein Coupled Receptor Heterodimeric Complex Neuron Projection Postsynaptic Membrane
	Molecular Function	Poly(A) RNA Binding	G-protein Coupled GABA Receptor Activity Protein Binding
	Biological Process	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Protein Homooligomerization	G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Inwardly rectifying K+ channels GABA B receptor activation Signaling by GPCR GABA receptor activation Activation of G protein gated Potassium channels Activation of GABAB receptors Potassium Channels Metabolic disorders of biological oxidation enzymes GPCR ligand binding G protein gated Potassium channels Class C/3 (Metabotropic glutamate/pheromone receptors) GPCR downstream signaling G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		2 interactors: ARAP1 GABBR2	9 interactors: ATF4 ATF5 GABBR1 GLP1R GRASP HTR1A KCTD12 NSF SH3GL3
Entrez ID		115207	9568
HPRD ID		11060	09552
Ensembl ID		ENSG00000178695	ENSG00000136928
Uniprot IDs		Q96CX2	H9NIL8 O75899
PDB IDs			4F11 4F12
Enriched GO Terms of Interacting Partners?		Actin Filament Reorganization Involved In Cell Cycle Actin Filament Reorganization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Receptor Recycling Positive Regulation Of Cdc42 GTPase Activity Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Receptor Recycling Regulation Of Cdc42 GTPase Activity Negative Regulation Of CAMP Biosynthetic Process Gamma-aminobutyric Acid Signaling Pathway Regulation Of Cdc42 Protein Signal Transduction Negative Regulation Of CAMP Metabolic Process Positive Regulation Of Filopodium Assembly Negative Regulation Of Nucleotide Metabolic Process Regulation Of Filopodium Assembly Regulation Of Adenylate Cyclase Activity Regulation Of Stress Fiber Assembly Regulation Of Cyclase Activity Actin Cytoskeleton Reorganization Regulation Of ARF GTPase Activity Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Regulation Of ARF Protein Signal Transduction Regulation Of Cell Projection Assembly Regulation Of Catalytic Activity Regulation Of Cell Shape Negative Regulation Of Cytoskeleton Organization	Gamma-aminobutyric Acid Signaling Pathway Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Metabolic Process Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Golgi Vesicle Docking Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Communication G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Secretion Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Circadian Rhythm Regulation Of Cellular Process Regulation Of Serotonin Secretion Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Olfactory Bulb Interneuron Development Negative Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Hormone Secretion Positive Regulation Of Transcription From RNA Polymerase I Promoter Signal Transduction Olfactory Bulb Interneuron Differentiation Negative Regulation Of Astrocyte Differentiation Serotonin Receptor Signaling Pathway Serotonin Metabolic Process Rhythmic Process Regulation Of Cellular Localization Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Receptor Recycling Regulation Of Dopamine Metabolic Process Plasma Membrane Fusion Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Tagcloud ?			a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?			a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?