CKS2 and TSC22D4

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CKS2	TSC22D4
Gene Name		CDC28 protein kinase regulatory subunit 2	TSC22 domain family, member 4
Image			No pdb structure
Gene Ontology Annotations	Cellular Component		Nucleus Cytoplasm
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Meiosis I Cell Proliferation Cell Division	Transcription, DNA-templated Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CCNA1 CCNA2 CCNB1 CCNB2 CDC37 CDK1 CDK2 CKS1B EEF1A1 GRB2 HSP90AA1 LDHB SSBP1 TSC22D4 UNC119 VTN	53 interactors: ABLIM1 AES AIFM1 APIP BLZF1 BZRAP1 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU ENKD1 FRMD6 FXR2 GNB2L1 GOLGA2 GORASP2 KEAP1 KPNA2 KRT40 LBP LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 SACS SAT1 SMAD3 SYT17 TEX11 TSC22D1 UBLCP1 ZBTB24 ZMYND10 ZNF580
Entrez ID		1164	81628
HPRD ID		00300	18231
Ensembl ID		ENSG00000123975	ENSG00000166925
Uniprot IDs		P33552	A8MWR6 Q9Y3Q8
PDB IDs		1CKS
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Catalytic Activity Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Cell Cycle Process Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Mitotic Nuclear Division Cell Cycle Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Mitotic Nuclear Envelope Disassembly Histone Phosphorylation Nuclear Envelope Disassembly Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Ras Protein Signal Transduction Nuclear Envelope Organization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Mitotic G2 DNA Damage Checkpoint Nucleus Organization Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Immune Response G2 DNA Damage Checkpoint Regulation Of Cell Cycle Process Cellular Response To Stress Positive Regulation Of Heart Growth Regulation Of Protein Ubiquitination Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition	Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Cell Cycle Negative Regulation Of Cell Death Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Catabolic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Proteolysis Negative Regulation Of Cell Cycle Positive Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Cellular Process Cell Cycle Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Ubiquitination Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cytokine Production Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Negative Regulation Of Intracellular Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Cell Death Regulation Of Protein Phosphorylation Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Signal Transduction Nitrogen Compound Metabolic Process Regulation Of Energy Homeostasis Negative Regulation Of Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Glycolytic Process Cellular Metabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		abundance antisense cdk2 cdnas contains cyclin disappears element encoding entry exists fraction greatly interference microinjection oligonucleotides p19 p21 p45 p9cks1 pcna prevented quaternary rearrangements reconstitution requires substantial transformed whose	ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting
Tagcloud (Difference) ?		abundance antisense cdk2 cdnas contains cyclin disappears element encoding entry exists fraction greatly interference microinjection oligonucleotides p19 p21 p45 p9cks1 pcna prevented quaternary rearrangements reconstitution requires substantial transformed whose	ablation cachectic cachexia clone deprivation diminished hepatic hepatocytes hypertriglyceridemia hypo hypobetalipoproteinemia lipids lipogenic livers mammals metabolic mimicking output proper rationale rescued secretion storage transforming triggers vldl wasting
Tagcloud (Intersection) ?