CKS2 and CCNB2

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		CKS2	CCNB2
Description		CDC28 protein kinase regulatory subunit 2	cyclin B2
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex SCF Ubiquitin Ligase Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm Centrosome Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Membrane
	Molecular Function	Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Cadherin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Meiosis I Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Fibroblast Proliferation Cell Division	G1/S Transition Of Mitotic Cell Cycle In Utero Embryonic Development Spindle Assembly Involved In Female Meiosis I G2/MI Transition Of Meiotic Cell Cycle Regulation Of Growth T Cell Homeostasis Mitotic Cell Cycle Phase Transition Thymus Development Cell Division
Pathways			Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization Resolution of Sister Chromatid Cohesion Condensation of Prometaphase Chromosomes Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Initiation of Nuclear Envelope (NE) Reformation Nuclear Pore Complex (NPC) Disassembly Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint The role of GTSE1 in G2/M progression after G2 checkpoint
Drugs
Diseases
GWAS		Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Metabolite levels ( 22916037)
Interacting Genes		15 interacting genes: BLZF1 CCNA1 CCNB2 CDC37 CDK1 CDK3 CKS1B EEF1A1 GRB2 HSP90AA1 LDHB SSBP1 TSC22D4 UNC119 VTN	7 interacting genes: CDK1 CDK2 CDKN1A CKS1B CKS2 MCM2 TGFBR2
Entrez ID		1164	9133
HPRD ID		00300	04131
Ensembl ID		ENSG00000123975	ENSG00000157456
Uniprot IDs		P33552	O95067
PDB IDs		1CKS 4Y72 4YC3 5HQ0 5LQF 6GU2 6GU3 6GU4 6GU6 6GU7
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin A1-CDK1 Complex Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Kinase Binding Extracellular Exosome Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin Binding Protein Folding Chaperone Complex Endodermal Cell Differentiation Positive Regulation Of Protein Import Into Nucleus Protein Kinase Binding Pronuclear Fusion Positive Regulation Of Organelle Organization DNA-templated DNA Replication Positive Regulation Of DNA Replication Guanyl-nucleotide Exchange Factor Adaptor Activity CTP Binding DATP Binding Symbiont-containing Vacuole Cell Cycle G2/M Phase Transition Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Positive Regulation Of DNA Metabolic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Cyclin A2-CDK1 Complex Grb2-EGFR Complex Neurofibrillary Tangle Assembly UTP Binding Scaffold Protein Binding Sulfonylurea Receptor Binding Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Smooth Muscle Cell-matrix Adhesion Meiosis I Cell Cycle Process Cyclin A1-CDK2 Complex Negative Regulation Of Caveolin-mediated Endocytosis G2/MI Transition Of Meiotic Cell Cycle HSP90-CDC37 Chaperone Complex Response To Osmotic Stress Protein Polymerization Centrosome Positive Regulation Of Cellular Component Organization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication	Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of DNA Replication Cyclin Binding Mitotic Cell Cycle Phase Transition Fibroblast Proliferation Regulation Of Mitotic Cell Cycle Positive Regulation Of DNA Replication Cyclin-dependent Protein Kinase Activity Cell Cycle Phase Transition Mitotic DNA Damage Checkpoint Signaling Histone Kinase Activity Mitotic DNA Integrity Checkpoint Signaling G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition DNA Damage Checkpoint Signaling Regulation Of G2/M Transition Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of Cell Cycle G2/M Phase Transition Cell Division Regulation Of Cell Cycle Mitotic G1 DNA Damage Checkpoint Signaling Regulation Of DNA-templated DNA Replication Initiation Mitotic G1/S Transition Checkpoint Signaling DNA Replication Regulation Of DNA Metabolic Process Signal Transduction In Response To DNA Damage Negative Regulation Of Mitotic Cell Cycle Phase Transition Histone Binding Chromosome, Telomeric Region Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Mitotic Cell Cycle Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Negative Regulation Of Cell Cycle Phase Transition Mitotic G2 DNA Damage Checkpoint Signaling Cell Population Proliferation Negative Regulation Of Cell Cycle Process DNA Damage Response Positive Regulation Of DNA Metabolic Process Intracellular Signaling Cassette G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Cell Cycle G2/M Phase Transition Positive Regulation Of Cell Population Proliferation Regulation Of Mitotic Cell Cycle Phase Transition SCF Ubiquitin Ligase Complex Negative Regulation Of Cell Cycle Cellular Senescence Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition
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