CKS2 and CDC37

Number of citations of the paper that reports this interaction (PubMedID 19786724)
39

Data Source:
BioGRID (pull down)

		CKS2	CDC37
Description		CDC28 protein kinase regulatory subunit 2	cell division cycle 37, HSP90 cochaperone
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex SCF Ubiquitin Ligase Complex	Cytoplasm Cytosol Extracellular Exosome Protein Folding Chaperone Complex HSP90-CDC37 Chaperone Complex
	Molecular Function	Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Protein Binding Protein Kinase Regulator Activity Kinase Binding Protein Kinase Binding Heat Shock Protein Binding Unfolded Protein Binding Protein-folding Chaperone Binding Hsp90 Protein Binding Scaffold Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Meiosis I Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Fibroblast Proliferation Cell Division	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Folding Protein Targeting Post-transcriptional Regulation Of Gene Expression Protein Stabilization Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Type 2 Mitophagy
Pathways			Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Regulation of necroptotic cell death Downregulation of ERBB2 signaling RHOBTB2 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) LDL cholesterol levels in HIV infection ( 33109212) Multiple sclerosis ( 21833088) White blood cell count ( 32888494)
Interacting Genes		15 interacting genes: BLZF1 CCNA1 CCNB2 CDC37 CDK1 CDK3 CKS1B EEF1A1 GRB2 HSP90AA1 LDHB SSBP1 TSC22D4 UNC119 VTN	182 interacting genes: A2M ACTB ACTG1 AKT1 AMOTL2 APOE APP AR BEND7 BLZF1 BTBD10 BTBD3 C19orf44 CAMK2A CAMK2B CAMK2G CARD10 CARD9 CAVIN1 CBY2 CC2D1A CCDC138 CCDC152 CCDC91 CCHCR1 CDC37L1 CDK2 CDK3 CDK4 CDK5 CDK6 CEP55 CEP70 CGGBP1 CHGA CHUK CKS1B CKS2 CRYM CSNK2A1 CSNK2A2 CT45A1 CTAG1A CTAG1B CUTC CYP2C9 DCTN1 DEAF1 DISC1 DRC4 ECSIT EIF2AK1 EIF2S1 ELAVL3 ENOX2 EXOSC1 FAM118A FAM9B FATE1 FBXL12 FBXW4 GABARAP GABARAPL1 GABARAPL2 GAS7 GCDH GCH1 GFAP GMCL1 GOLGA2 GOLGA6L9 GPRASP3 GRAMD2B GRIPAP1 HIVEP1 HOMER3 HSF2BP HSP90AA1 IFIT5 IKBKB IKBKE IKBKG IKZF3 IMMT JRK KATNBL1 KCTD13 KCTD9 KIFC3 KLHL2 KRT75 KRT76 LMNB2 LONP1 LOXL4 LUC7L2 LZTS1 MAD1L1 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K14 MAP3K3 MDFI MID1 MIPOL1 MRPL9 MTOR MZT2B NCOA5 NECAB1 NECAB2 NOS3 NR2C2 NRIP3 NT5C1A OGA OGT PAICS PDE9A PIBF1 PNMA2 POU6F2 PPHLN1 PPP5C PRAM1 PRDX2 PRKAR1B PRMT1 PRMT5 PRPH PRR20A PRR20B PRR20C PRR20D PRR20E PSMC6 PSME1 PTGES3 RABGEF1 RAD23A RAF1 REEP6 RNF32 ROPN1 RPS15A SAFB SEPTIN3 SNX5 SPTBN4 SQSTM1 SRRM4 SSNA1 STAMBPL1 STIP1 STK11 STX1A SYCE2 SYCP3 TBK1 TCF4 THAP1 THAP7 TNFAIP1 TNIP1 TRAF2 TRAF3 TRAF5 TRIM54 UBE2I USHBP1 WAC ZBED1 ZBTB26 ZBTB8A ZNF205 ZNF235 ZNF266 ZNF276 ZNF655 ZNF667 ZNF837
Entrez ID		1164	11140
HPRD ID		00300	05456
Ensembl ID		ENSG00000123975	ENSG00000105401
Uniprot IDs		P33552	Q16543
PDB IDs		1CKS 4Y72 4YC3 5HQ0 5LQF 6GU2 6GU3 6GU4 6GU6 6GU7	1US7 2K5B 2N5X 2NCA 2W0G 5FWK 5FWL 5FWM 5FWP 5HPE 7Z37 7Z38 7ZR0 7ZR5 7ZR6 8GAE 8GFT 8U1L
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin A1-CDK1 Complex Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Kinase Binding Extracellular Exosome Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin Binding Protein Folding Chaperone Complex Endodermal Cell Differentiation Positive Regulation Of Protein Import Into Nucleus Protein Kinase Binding Pronuclear Fusion Positive Regulation Of Organelle Organization DNA-templated DNA Replication Positive Regulation Of DNA Replication Guanyl-nucleotide Exchange Factor Adaptor Activity CTP Binding DATP Binding Symbiont-containing Vacuole Cell Cycle G2/M Phase Transition Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Positive Regulation Of DNA Metabolic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Cyclin A2-CDK1 Complex Grb2-EGFR Complex Neurofibrillary Tangle Assembly UTP Binding Scaffold Protein Binding Sulfonylurea Receptor Binding Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Smooth Muscle Cell-matrix Adhesion Meiosis I Cell Cycle Process Cyclin A1-CDK2 Complex Negative Regulation Of Caveolin-mediated Endocytosis G2/MI Transition Of Meiotic Cell Cycle HSP90-CDC37 Chaperone Complex Response To Osmotic Stress Protein Polymerization Centrosome Positive Regulation Of Cellular Component Organization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication	Identical Protein Binding Cytosol Protein Binding Cytoplasm Cellular Response To Nitrogen Starvation Mitophagy Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Serine/threonine Kinase Activity Phosphatidylethanolamine Binding Autophagy Of Mitochondrion Protein Serine Kinase Activity Regulation Of Canonical NF-kappaB Signal Transduction Organelle Organization Macroautophagy Positive Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Signal Transduction CD40 Receptor Complex Protein Kinase Activity Regulation Of Proteolysis Regulation Of Intracellular Signal Transduction Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Localization To Membrane Cyclin-dependent Protein Kinase Holoenzyme Complex IkappaB Kinase Complex Negative Regulation Of Translational Initiation Microtubule Binding Autophagy Regulation Of Protein Localization To Cell Periphery Regulation Of Signal Transduction Intracellular Protein Localization IkappaB Kinase Activity Regulation Of Signaling Regulation Of Cell Communication Serine/threonine Protein Kinase Complex Regulation Of Protein Catabolic Process Kinase Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Synaptic Transmission Cellular Response To Nutrient Levels Cellular Response To Starvation Response To Starvation Toll-like Receptor 4 Signaling Pathway Regulation Of Protein Localization To Plasma Membrane Anoikis Positive Regulation Of TORC1 Signaling Tau Protein Binding Regulation Of Macroautophagy
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