CKS2 and SSBP1

Number of citations of the paper that reports this interaction (PubMedID 19786724)
39

Data Source:
BioGRID (pull down)

		CKS2	SSBP1
Description		CDC28 protein kinase regulatory subunit 2	single stranded DNA binding protein 1
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GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex SCF Ubiquitin Ligase Complex	Nucleus Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid Extracellular Exosome
	Molecular Function	Chromatin Binding Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	DNA Binding Chromatin Binding Single-stranded DNA Binding RNA Binding Protein Binding Enzyme Activator Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Meiosis I Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Fibroblast Proliferation Cell Division	DNA Replication DNA-templated DNA Replication Positive Regulation Of Helicase Activity Protein Homotetramerization Positive Regulation Of Mitochondrial DNA Replication
Pathways			Transcriptional activation of mitochondrial biogenesis Mitochondrial protein degradation Strand-asynchronous mitochondrial DNA replication
Drugs
Diseases
GWAS		Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Anorexia nervosa ( 23568457)
Interacting Genes		15 interacting genes: BLZF1 CCNA1 CCNB2 CDC37 CDK1 CDK3 CKS1B EEF1A1 GRB2 HSP90AA1 LDHB SSBP1 TSC22D4 UNC119 VTN	13 interacting genes: CDK1 CEBPA CKS1B CKS2 FOXP1 GCM2 LDB1 LGALS7 LGALS7B OTUD6A POLG TP53 YWHAQ
Entrez ID		1164	6742
HPRD ID		00300	02703
Ensembl ID		ENSG00000123975	ENSG00000106028
Uniprot IDs		P33552	A4D1U3 B7Z268 Q04837
PDB IDs		1CKS 4Y72 4YC3 5HQ0 5LQF 6GU2 6GU3 6GU4 6GU6 6GU7	1S3O 2DUD 3ULL 6RUP 8UZT
Enriched GO Terms of Interacting Partners?		Cyclin-dependent Protein Kinase Holoenzyme Complex Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Cyclin A1-CDK1 Complex Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Division Kinase Binding Extracellular Exosome Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin Binding Protein Folding Chaperone Complex Endodermal Cell Differentiation Positive Regulation Of Protein Import Into Nucleus Protein Kinase Binding Pronuclear Fusion Positive Regulation Of Organelle Organization DNA-templated DNA Replication Positive Regulation Of DNA Replication Guanyl-nucleotide Exchange Factor Adaptor Activity CTP Binding DATP Binding Symbiont-containing Vacuole Cell Cycle G2/M Phase Transition Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Positive Regulation Of DNA Metabolic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Cyclin A2-CDK1 Complex Grb2-EGFR Complex Neurofibrillary Tangle Assembly UTP Binding Scaffold Protein Binding Sulfonylurea Receptor Binding Positive Regulation Of Helicase Activity Positive Regulation Of Mitochondrial DNA Replication Smooth Muscle Cell-matrix Adhesion Meiosis I Cell Cycle Process Cyclin A1-CDK2 Complex Negative Regulation Of Caveolin-mediated Endocytosis G2/MI Transition Of Meiotic Cell Cycle HSP90-CDC37 Chaperone Complex Response To Osmotic Stress Protein Polymerization Centrosome Positive Regulation Of Cellular Component Organization Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication	Chromatin Binding Fibroblast Proliferation Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleobase-containing Compound Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Mitochondrial DNA Metabolic Process Core Promoter Sequence-specific DNA Binding Negative Regulation Of Stem Cell Proliferation DNA-templated Transcription Protein-containing Complex Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity 14-3-3 Protein Binding Regulation Of RNA Metabolic Process Pronuclear Fusion Mitotic DNA-templated DNA Replication Regulation Of DNA-templated Transcription Mitotic DNA Replication DNA Synthesis Involved In Mitotic DNA Replication Cell Differentiation Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Mitotic DNA Integrity Checkpoint Signaling Cyclin B1-CDK1 Complex Macromolecule Biosynthetic Process Cell Population Proliferation Cyclin A1-CDK1 Complex Regulation Of Heart Growth DNA-templated DNA Replication DNA Biosynthetic Process Regulation Of Mitotic Cell Cycle Cyclin A2-CDK1 Complex Cyclin-dependent Protein Kinase Activity Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Transcription Regulator Complex Positive Regulation Of DNA-templated Transcription Initiation CHOP-C/EBP Complex Stem Cell Proliferation Regulation Of Stem Cell Proliferation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Mononuclear Cell Differentiation Cellular Response To Xenobiotic Stimulus Regulation Of DNA-templated Transcription Initiation Negative Regulation Of Cell Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Response To Vitamin B2 C/EBP Complex SCF Ubiquitin Ligase Complex DNA Replication Proofreading
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