MAGEA1 and SELPLG

Number of citations: 47 (PubMedID 25910212)
Data Source: BioGRID (two hybrid)

		MAGEA1	SELPLG
Name		MAGE family member A1	selectin P ligand
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Uropod Plasma Membrane Membrane Plasma Membrane Raft
	Molecular Function	Protein Binding Histone Deacetylase Binding	Virus Receptor Activity Signaling Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Notch Signaling Pathway	Cell Adhesion Symbiont Entry Into Host Cell Leukocyte Migration Leukocyte Tethering Or Rolling Leukocyte Adhesive Activation Cellular Response To Interleukin-6
Pathways		None	Cell surface interactions at the vascular wall
Drugs		None	Neihulizumab
GWAS		No GWAS studies recorded	Acne (severe) ( 24927181 ) Blood protein levels ( 30072576 ) Brain morphology (MOSTest) ( 32665545 ) Conduct disorder (symptom count) ( 20585324 )
Novel Interactors		None recorded	3 novel interactors: CIT ECSIT MVK
Interacting Genes		25 interacting genes: ABI2 CEP57L1 DNM1L HDAC1 HLA-A HLA-B HYPK LRSAM1 MDM4 MIEF1 NOTCH1 PBX3 PCGF6 RAB17 RNF166 S100A9 SELPLG SFN SGK1 SH3GLB2 SHFL SNW1 TRIM31 UQCRB ZNF564	14 interacting genes: BACE1 CTSG GALNT4 MAGEA1 MSN SELE SELL SELP SLC13A1 SYK TNIP1 TPST1 TPST2 VCAN
Entrez ID		4100	6404
HPRD ID		02059	02845
Ensembl ID		ENSG00000198681	ENSG00000110876
Uniprot IDs		P43355	Q14242
PDB IDs		1W72 3BO8	1G1S
GO Terms Enriched among Interactors		TAP Binding Compartment Pattern Specification Protection From Natural Killer Cell Mediated Cytotoxicity MHC Class I Protein Complex Detection Of Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Mitochondrial Fission Regulation Of Cellular Component Organization Response To External Biotic Stimulus Epidermal Cell Differentiation Negative Regulation Of Innate Immune Response Negative Regulation Of Myotube Differentiation Innate Immune Response Recycling Endosome Membrane Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Atrioventricular Valve Morphogenesis Endocardial Cushion Morphogenesis Positive Regulation Of Mitochondrial Fission Defense Response Host-mediated Perturbation Of Symbiont Process Notch Binding Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Defense Response To Symbiont Modulation Of Process Of Another Organism Defense Response To Other Organism Response To Other Organism Positive Regulation Of Epidermal Cell Differentiation Host-mediated Perturbation Of Viral Transcription Antigen Processing And Presentation Of Endogenous Antigen Regulation Of Mitochondrial Fission Lumenal Side Of Endoplasmic Reticulum Membrane Autophagy Detection Of Biotic Stimulus Positive Regulation Of Epidermis Development Endoderm Development Regulation Of Viral Process Positive Regulation Of Glial Cell Differentiation Positive Regulation Of T Cell Mediated Cytotoxicity Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Notch Signaling Pathway Involved In Regulation Of Secondary Heart Field Cardioblast Proliferation Venous Endothelial Cell Differentiation Coronary Sinus Valve Morphogenesis Foregut Morphogenesis Posterior Compartment Specification Anterior Compartment Pattern Formation S100A9 Complex Viral Process	Leukocyte Cell-cell Adhesion Leukocyte Migration Oligosaccharide Binding Carbohydrate Binding Leukocyte Tethering Or Rolling Sialic Acid Binding Protein-tyrosine Sulfotransferase Activity Leukocyte Adhesion To Vascular Endothelial Cell Cell-cell Adhesion Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell Migration Glycosphingolipid Binding Regulation Of Platelet Activation Cell Motility Positive Regulation Of Leukocyte Tethering Or Rolling Regulation Of Leukocyte Tethering Or Rolling 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Golgi Lumen Response To Lipopolysaccharide Immune System Process Phospholipase Binding Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Response To Molecule Of Bacterial Origin Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Immune System Process Neutrophil Activation Positive Regulation Of Receptor Internalization Regulation Of Platelet Aggregation Regulation Of Leukocyte Cell-cell Adhesion Heparin Binding Regulation Of Immune System Process Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Pattern Recognition Receptor Signaling Pathway Regulation Of Inflammatory Response Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Innate Immune Response-activating Signaling Pathway Trans-Golgi Network Signaling Receptor Ligand Precursor Processing Response To Lipid Biofilm Matrix Disassembly Regulation Of Defense Response Mevalonate Kinase Activity Interleukin-15 Receptor Binding Positive Regulation Of Interleukin-3 Production Peptidyl-tyrosine Sulfation Golgi-associated Vesicle Lumen Activation Of Innate Immune Response Response To External Biotic Stimulus