COA8 and TRMT61A

		COA8	TRMT61A
Description		cytochrome c oxidase assembly factor 8	tRNA methyltransferase 61A
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Membrane Matrix Side Of Mitochondrial Inner Membrane	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex
	Molecular Function	Protein Binding	Protein Binding Methyltransferase Activity Transferase Activity MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity
	Biological Process	Response To Reactive Oxygen Species Apoptotic Process Mitochondrial Cytochrome C Oxidase Assembly Protein Stabilization Intrinsic Apoptotic Signaling Pathway	RNA Processing MRNA Processing TRNA Processing TRNA Methylation Methylation
Pathways			tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Branched-chain amino acid levels (Isoleucine) ( 27898682) Extremely high intelligence ( 29520040) Hemoglobin levels ( 32327693) Intelligence (MTAG) ( 29326435) Mean corpuscular volume ( 27863252 32888494) Red blood cell count ( 32888494) Schizophrenia ( 25056061)
Interacting Genes			2 interacting genes: TCL1A TRMT6
Entrez ID		84334	115708
HPRD ID		12637	08810
Ensembl ID		ENSG00000256053	ENSG00000166166
Uniprot IDs		A0A6Q8JUI0 G3V4L6 Q96IL0	Q96FX7
PDB IDs			5CCB 5CCX 5CD1
Enriched GO Terms of Interacting Partners?		MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity Transposable Element Silencing By PiRNA-mediated Heterochromatin Formation PiP-body
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