CIRBP and SRSF3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CIRBP	SRSF3
Description		cold inducible RNA binding protein	serine and arginine rich splicing factor 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytoplasmic Stress Granule	Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Repressor Activity Small Ribosomal Subunit RRNA Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding Phospholipase Binding Primary MiRNA Binding Protein-RNA Sequence-specific Adaptor Activity Sequence-specific MRNA Binding
	Biological Process	Response To Cold Response To UV Negative Regulation Of Translation Stress Granule Assembly Positive Regulation Of Translation Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization	Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Processing MRNA Processing MRNA Export From Nucleus RNA Splicing Primary MiRNA Processing Regulation Of MRNA Splicing, Via Spliceosome MRNA Transport Cellular Response To Leukemia Inhibitory Factor
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)	Glaucoma (primary open-angle) ( 33627673) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		21 interacting genes: APP ATXN1 BAG5 CEBPA CSNK2A1 FBXO7 HNRNPA0 HNRNPK IL7R KHDRBS1 KHDRBS2 LNX1 NEIL3 PRMT1 RBMX RBMY1A1 RBMY1F SNRPA SRF SRSF3 UBC	40 interacting genes: - APP BCL2L13 CHD1 CIRBP CLK3 CNNM3 DUX4 EXOSC6 FOXP1 GEMIN2 HMGB1 HNRNPK IL7R LNX1 NXF1 PCBP1 PCBP2 PCBP3 PCDHB14 PRPF31 RBM3 RBM7 RBMY1A1 RNF10 RNPS1 RPL9 SCAF11 SDCBP SREK1 SRPK1 SRPK2 SRSF2 SRSF8 TRA2B U2AF1 U2AF2 YWHAB YWHAG YWHAQ
Entrez ID		1153	6428
HPRD ID		08375	04530
Ensembl ID		ENSG00000099622	ENSG00000112081
Uniprot IDs		D6W5Y5 K7EPM4 K7EQR7 Q14011 Q53XX5	B2R6F3 P84103
PDB IDs		1X5S 5TBX 8CMK	2I2Y 2I38 9ASQ
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of MRNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding RNA Metabolic Process MRNA Metabolic Process RNA Processing MRNA Processing Regulation Of RNA Splicing Nucleoplasm Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Binding RNA Splicing Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Spliceosomal Complex Poly(U) RNA Binding Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Memory Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Splicing Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Primary MiRNA Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Protein Domain Specific Binding Negative Regulation Of RNA Metabolic Process Associative Learning Protein-containing Complex Chromatin Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Amyloid-beta Clearance Poly(A) Binding	Regulation Of MRNA Splicing, Via Spliceosome RNA Binding Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Metabolic Process RNA Splicing Nucleic Acid Binding MRNA Processing RNA Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex RNA Processing Nucleus Nuclear Speck Nucleoplasm Nucleic Acid Metabolic Process MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Splicing Spliceosomal Complex Assembly Regulation Of Gene Expression Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Viral RNA Genome Replication Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Metabolic Process Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Viral Genome Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of Biosynthetic Process Focal Adhesion Negative Regulation Of RNA Metabolic Process 14-3-3 Protein Binding Pre-mRNA 3'-splice Site Binding U2AF Complex Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein Sequestering Activity Protein Domain Specific Binding Ribonucleoprotein Complex
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