CIRBP and KHDRBS2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CIRBP	KHDRBS2
Description		cold inducible RNA binding protein	KH RNA binding domain containing, signal transduction associated 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytoplasm Cytoplasmic Stress Granule	Nucleus Nucleoplasm
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Translation Repressor Activity Small Ribosomal Subunit RRNA Binding	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding SH2 Domain Binding
	Biological Process	Response To Cold Response To UV Negative Regulation Of Translation Stress Granule Assembly Positive Regulation Of Translation Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Stabilization	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome
Pathways			PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494)	Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Chronotype ( 30696823) Corneal astigmatism ( 30306274) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Esophageal adenocarcinoma ( 27527254) Presence of antiphospholipid antibodies ( 27098658) Protein quantitative trait loci ( 18464913)
Interacting Genes		21 interacting genes: APP ATXN1 BAG5 CEBPA CSNK2A1 FBXO7 HNRNPA0 HNRNPK IL7R KHDRBS1 KHDRBS2 LNX1 NEIL3 PRMT1 RBMX RBMY1A1 RBMY1F SNRPA SRF SRSF3 UBC	54 interacting genes: AEN BAHD1 BMP7 CATSPER1 CHTOP CIRBP CNNM3 DALRD3 DOCK2 EWSR1 FOXD4L3 GRAP2 GRB2 HBZ HHEX HNRNPA0 HNRNPK HNRNPLL HNRNPR KHDRBS3 LINC01018 LMNTD2 LNX1 MSI2 MTA1 NABP1 NCOA5 NPDC1 PRMT1 PRPF31 PRR3 PSMF1 PTK6 RBFOX2 RBM10 RBM14 RBM3 RBMX RFC3 RPP30 SDCBP SF1 SF3B4 SPG7 SULT1A3 TMEM14B TYK2 TYMSOS YTHDC1 ZFC3H1 ZNF497 ZNF581 ZNF688 ZNF837
Entrez ID		1153	202559
HPRD ID		08375	13775
Ensembl ID		ENSG00000099622	ENSG00000112232
Uniprot IDs		D6W5Y5 K7EPM4 K7EQR7 Q14011 Q53XX5	Q5VWX1
PDB IDs		1X5S 5TBX 8CMK
Enriched GO Terms of Interacting Partners?		Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Regulation Of MRNA Processing Nucleic Acid Metabolic Process Nucleic Acid Binding RNA Metabolic Process MRNA Metabolic Process RNA Processing MRNA Processing Regulation Of RNA Splicing Nucleoplasm Regulation Of MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Binding RNA Splicing Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Identical Protein Binding Spliceosomal Complex Poly(U) RNA Binding Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Gene Expression Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Memory Positive Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of RNA Splicing Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Primary MiRNA Binding Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Metabolic Process Protein Domain Specific Binding Negative Regulation Of RNA Metabolic Process Associative Learning Protein-containing Complex Chromatin Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Amyloid-beta Clearance Poly(A) Binding	RNA Binding RNA Processing Nucleic Acid Binding Regulation Of MRNA Splicing, Via Spliceosome Regulation Of RNA Splicing Regulation Of MRNA Processing MRNA Binding MRNA Processing MRNA Splicing, Via Spliceosome RNA Splicing RNA Splicing, Via Transesterification Reactions MRNA Metabolic Process Regulation Of MRNA Metabolic Process Spliceosomal Complex Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleus Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Primary Metabolic Process Positive Regulation Of RNA Splicing Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Metabolic Process RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Protein Binding Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Splicing Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Gene Expression Splicing Factor Binding Negative Regulation Of Macromolecule Metabolic Process Ribonucleoprotein Complex Regulation Of Metabolic Process Identical Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Response To Ionizing Radiation MRNA Stabilization Negative Regulation Of Biosynthetic Process Precatalytic Spliceosome
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