TTC5 and CAMK2D

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TTC5	CAMK2D
Description		tetratricopeptide repeat domain 5	calcium/calmodulin dependent protein kinase II delta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Cytoplasmic Vesicle	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Membrane Sarcoplasmic Reticulum Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Neuron Projection
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Ribosome Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium/calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Kinase Activity Transferase Activity Sodium Channel Inhibitor Activity Titin Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Serine Kinase Activity
	Biological Process	DNA Repair DNA Damage Response Cellular Response To Starvation Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Positive Regulation Of MRNA Catabolic Process	Regulation Of Cell Growth Regulation Of The Force Of Heart Contraction Regulation Of Membrane Depolarization Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Regulation Of Heart Contraction Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Neuronal Synaptic Plasticity Relaxation Of Cardiac Muscle Long-term Synaptic Potentiation Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cellular Localization Cellular Response To Calcium Ion Cardiac Muscle Cell Contraction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Regulation Of Protein Localization To Plasma Membrane
Pathways		Regulation of TP53 Activity through Methylation	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs			2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Fostamatinib
Diseases
GWAS		Alzheimer's disease progression score ( 29860282)	Atrial fibrillation ( 30061737 29892015) Chronic lymphocytic leukemia ( 24292274 28165464) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 28552196) Non-small cell lung cancer (survival) ( 25145502) P wave duration ( 28794112) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033 32439900) Small vessel stroke (CCS and TOAST classification) ( 32047268) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560) White matter integrity (bipolar disorder risk interaction) ( 23218918)
Interacting Genes		9 interacting genes: CAMK2A CAMK2B CAMK2D CAMK2G CAVIN1 DDIT4L GOLGA6A HDX JMY	30 interacting genes: ACTN2 ARL2BP BANP CAMK2B CD5 CREM EPHA10 ERCC8 FAM171B FKBP1B FNDC3B GRIN2B HNMT IFNGR2 MOAP1 MRPL11 RNF4 RPS18 RPS4X SMARCB1 SPATA24 SRPK1 STAT1 TNPO2 TNPO3 TTC5 UBC UBE2I VIM WASF3
Entrez ID		91875	817
HPRD ID		15584	09653
Ensembl ID		ENSG00000136319	ENSG00000145349
Uniprot IDs		Q86T04 Q8N0Z6	A0A8V8TN60 A0A8V8TN65 A0A8V8TN88 A0A8V8TNA1 A0A8V8TNA7 A0A8V8TPJ8 A0A8V8TPY4 A0A994J516 A0A994J5B0 D6R938 E9PBG7 E9PF82 Q13557
PDB IDs		2XVS 6T59 7QWS 8BPO	2VN9 2W2C 2WEL 3GP2 5VLO 6AYW 7ZRP 7ZRQ 8USO
Enriched GO Terms of Interacting Partners?		Calcium- And Calmodulin-dependent Protein Kinase Complex Calcium/calmodulin-dependent Protein Kinase Activity Long-term Synaptic Potentiation Regulation Of Neuronal Synaptic Plasticity Endocytic Vesicle Membrane Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Synaptic Transmission Regulation Of Protein Localization To Cell Periphery Sarcoplasmic Reticulum Membrane Regulation Of Protein Localization To Membrane Calmodulin Binding Regulation Of Synaptic Plasticity Regulation Of Calcium Ion Transport Sarcoplasmic Reticulum Postsynaptic Density Regulation Of Skeletal Muscle Adaptation Neuron Projection Regulation Of Metal Ion Transport Protein Serine Kinase Activity Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Serine/threonine Kinase Activity Regulation Of Monoatomic Ion Transport Modulation Of Chemical Synaptic Transmission Protein Kinase Activity Regulation Of Cellular Localization Kinase Activity Regulation Of Muscle System Process Regulation Of Neuron Migration Regulation Of Cardiac Muscle Cell Apoptotic Process Protein Homodimerization Activity Peptidyl-threonine Autophosphorylation 'de Novo' Actin Filament Nucleation Protein Phosphorylation Regulation Of Protein Localization Phosphorylation Identical Protein Binding Regulation Of Endocannabinoid Signaling Pathway Calcium-dependent Protein Serine/threonine Phosphatase Activity Termination Of RNA Polymerase I Transcription RRNA Primary Transcript Binding Protein Autophosphorylation Protein Localization To Extracellular Region Establishment Of Protein Localization To Extracellular Region Protein Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of System Process Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Relaxation Of Cardiac Muscle Glutamate Receptor Binding	Cytoplasm Nuclear Matrix
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