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PNMA5 and PSMA1
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
PNMA5
PSMA1
Gene Name
paraneoplastic Ma antigen family member 5
proteasome (prosome, macropain) subunit, alpha type, 1
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Centrosome
Cytosol
Proteasome Core Complex
Polysome
Proteasome Core Complex, Alpha-subunit Complex
Extracellular Vesicular Exosome
Molecular Function
RNA Binding
Threonine-type Endopeptidase Activity
Protein Binding
Biological Process
Positive Regulation Of Apoptotic Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Mitotic Cell Cycle
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Gene Expression
Viral Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Nitrogen Compound Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Small Molecule Metabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
Hh ligand biogenesis disease
T41 mutants of beta-catenin aren't phosphorylated
Downstream signaling events of B Cell Receptor (BCR)
Degradation of beta-catenin by the destruction complex
Stabilization of p53
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
Removal of licensing factors from origins
Switching of origins to a post-replicative state
Mitotic G1-G1/S phases
Regulation of mRNA stability by proteins that bind AU-rich elements
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
DNA Replication Pre-Initiation
S45 mutants of beta-catenin aren't phosphorylated
APC/C:Cdc20 mediated degradation of mitotic proteins
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
AMER1 mutants destabilize the destruction complex
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
PCP/CE pathway
Adaptive Immune System
CDK-mediated phosphorylation and removal of Cdc6
Hedgehog ligand biogenesis
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
HIV Infection
Ubiquitin-dependent degradation of Cyclin D
APC truncation mutants have impaired AXIN binding
Assembly of the pre-replicative complex
Autodegradation of Cdh1 by Cdh1:APC/C
p53-Dependent G1 DNA Damage Response
S37 mutants of beta-catenin aren't phosphorylated
XAV939 inhibits tankyrase, stabilizing AXIN
p53-Independent DNA Damage Response
p53-Independent G1/S DNA damage checkpoint
G1/S DNA Damage Checkpoints
Vpu mediated degradation of CD4
Synthesis of DNA
M/G1 Transition
Ubiquitin-dependent degradation of Cyclin D1
TCF dependent signaling in response to WNT
SCF-beta-TrCP mediated degradation of Emi1
degradation of AXIN
Signaling by Hedgehog
Regulation of mitotic cell cycle
Degradation of GLI1 by the proteasome
degradation of DVL
Cell Cycle Checkpoints
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Regulation of Apoptosis
Degradation of GLI2 by the proteasome
Signaling by the B Cell Receptor (BCR)
Vif-mediated degradation of APOBEC3G
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
p53-Dependent G1/S DNA damage checkpoint
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Signaling by Wnt
Cyclin E associated events during G1/S transition
APC/C:Cdc20 mediated degradation of Securin
AUF1 (hnRNP D0) destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
RNF mutants show enhanced WNT signaling and proliferation
G1/S Transition
truncations of AMER1 destabilize the destruction complex
Processing-defective Hh variants abrogate ligand secretion
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
Regulation of activated PAK-2p34 by proteasome mediated degradation
AXIN missense mutants destabilize the destruction complex
S Phase
APC/C-mediated degradation of cell cycle proteins
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic Metaphase and Anaphase
Regulation of ornithine decarboxylase (ODC)
Antigen processing: Ubiquitination & Proteasome degradation
Orc1 removal from chromatin
Mitotic Anaphase
M Phase
APC truncation mutants are not K63 polyubiquitinated
Metabolism of amino acids and derivatives
Hedgehog 'on' state
Programmed Cell Death
Class I MHC mediated antigen processing & presentation
Regulation of DNA replication
Cell Cycle, Mitotic
beta-catenin independent WNT signaling
Orc1 removal from chromatin
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Antigen processing-Cross presentation
CDT1 association with the CDC6:ORC:origin complex
ER-Phagosome pathway
Drugs
Diseases
GWAS
Alzheimer's disease (cognitive decline) (
23535033
)
Protein-Protein Interactions
32 interactors:
AP1M1
ARPC4
C11orf49
CARD9
CCDC102B
CCNC
CDC23
CEP57L1
CETN2
DDX6
GLIPR2
GORASP2
GRB2
KPNA2
MOAP1
MYO15B
PNMA1
POLR3C
PRKAA1
PSMA1
RAD23B
SH3KBP1
TBC1D22B
TNPO2
TTC23
TXNL4B
VIM
VPS28
WDYHV1
ZBTB25
ZFYVE26
ZMYND19
87 interactors:
ABCD3
ABI3
ACTN1
APIP
APP
BLZF1
C11orf49
CALCOCO2
CBS
CCDC102B
CCDC85B
CCNH
CDA
CEP70
CEP72
COIL
COX2
DLEU1
EHMT2
GLTSCR2
GNPTAB
GOLGA2
HOMER3
HSD17B14
IFT20
IKZF1
IKZF3
INO80E
KCTD1
KCTD17
KCTD9
KRT15
KRT31
KRT38
KRT40
KRTAP5-9
LDB1
LDOC1
LZTS2
MAD1L1
MAPRE1
MAPRE3
MCM6
MID2
MKRN3
MLH1
MRFAP1L1
MTUS2
NECAB2
NMI
NOTCH2NL
PARK2
PLK1
PNMA1
PNMA2
PNMA5
POMP
PRDM14
PSMA2
PSMA3
PSMA4
PSMA7
PSMB10
PSMB2
PSMB5
PSMB9
RAD54B
REL
ROPN1
SFMBT1
SH3BP4
SH3GLB1
SSX2IP
TCF12
TCF4
TDO2
TNFAIP1
TNR
TRAF1
TRIM10
TRIM23
TRIM27
TRIM42
TSC22D4
UBXN11
VCP
VIM
Entrez ID
114824
5682
HPRD ID
06678
04170
Ensembl ID
ENSG00000198883
ENSG00000129084
Uniprot IDs
Q96PV4
B4E0X6
P25786
PDB IDs
Enriched GO Terms of Interacting Partners
?
Organelle Organization
Viral Process
Negative Regulation Of Protein Ubiquitination
Cellular Response To DNA Damage Stimulus
Enzyme Linked Receptor Protein Signaling Pathway
Cell Cycle
Response To Stress
Cell Cycle Process
Negative Regulation Of Glucosylceramide Biosynthetic Process
Cold Acclimation
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Cellular Response To Stress
Negative Regulation Of ERBB Signaling Pathway
Mitotic Cell Cycle
Regulation Of Protein Ubiquitination
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Nucleotide-excision Repair, DNA Damage Recognition
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Negative Regulation Of Ubiquitin-protein Transferase Activity
Modification-dependent Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Positive Regulation Of Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Proteolysis Involved In Cellular Protein Catabolic Process
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Negative Regulation Of Glucose Import In Response To Insulin Stimulus
Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Cellular Protein Localization
Positive Regulation Of Ligase Activity
Regulation Of Cell Cycle
Cellular Protein Catabolic Process
Regulation Of ERBB Signaling Pathway
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Response To Camptothecin
Protein Insertion Into Mitochondrial Membrane
Regulation Of Ubiquitin-protein Transferase Activity
Protein Catabolic Process
Regulation Of MAPK Cascade
Regulation Of Cellular Component Organization
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Signal Transduction In Response To DNA Damage
Nucleotide-excision Repair
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Mitotic Cell Cycle
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Cellular Protein Catabolic Process
Positive Regulation Of Ligase Activity
Cell Cycle Process
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Regulation Of Ubiquitin-protein Transferase Activity
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Positive Regulation Of Protein Ubiquitination
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Signal Transduction Involved In DNA Damage Checkpoint
Signal Transduction Involved In Cell Cycle Checkpoint
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Mitotic Cell Cycle Process
Protein Ubiquitination
Negative Regulation Of Ubiquitin-protein Transferase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Protein Modification By Small Protein Conjugation
Mitotic Cell Cycle Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Mitotic G1 DNA Damage Checkpoint
G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Catabolic Process
Mitotic G1/S Transition Checkpoint
G1 DNA Damage Checkpoint
Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cell Cycle Arrest
Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Proteolysis
Protein Polyubiquitination
DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Wnt Signaling Pathway
Signal Transduction In Response To DNA Damage
Mitotic DNA Damage Checkpoint
Regulation Of Protein Ubiquitination
Regulation Of Cell Cycle Arrest
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Mitotic DNA Integrity Checkpoint
Negative Regulation Of Protein Ubiquitination
Tagcloud
?
20s
alpha5
alpha6
alpha7
alphal
apparatus
cations
dephosphorylation
electrophoretic
endonuclease
endoribonuclease
hydrolysates
possession
postranslational
proteasomal
proteasome
proteasomes
proteolysis
psma3
psma5
psma6
ptm
ribonucleoprotein
rnase
scarcely
spectrometric
tryptic
utr
varies
Tagcloud (Difference)
?
20s
alpha5
alpha6
alpha7
alphal
apparatus
cations
dephosphorylation
electrophoretic
endonuclease
endoribonuclease
hydrolysates
possession
postranslational
proteasomal
proteasome
proteasomes
proteolysis
psma3
psma5
psma6
ptm
ribonucleoprotein
rnase
scarcely
spectrometric
tryptic
utr
varies
Tagcloud (Intersection)
?