PGLYRP3 and HSD17B14

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGLYRP3	HSD17B14
Description		peptidoglycan recognition protein 3	hydroxysteroid 17-beta dehydrogenase 14
Image
GO Annotations	Cellular Component	Extracellular Region Membrane Protein-containing Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding Zinc Ion Binding N-acetylmuramoyl-L-alanine Amidase Activity Peptidoglycan Immune Receptor Activity Peptidoglycan Binding Protein Heterodimerization Activity	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Oxidoreductase Activity Identical Protein Binding D-threo-aldose 1-dehydrogenase Activity
	Biological Process	Immune System Process Immune Response Peptidoglycan Catabolic Process Detection Of Bacterium Killing Of Cells Of Another Organism Negative Regulation Of Type II Interferon Production Negative Regulation Of Natural Killer Cell Differentiation Involved In Immune Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-positive Bacterium Biological Process Involved In Interaction With Host Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Fucose Metabolic Process Lipid Metabolic Process Steroid Metabolic Process L-fucose Catabolic Process
Pathways		Antimicrobial peptides	Estrogen biosynthesis
Drugs		2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE(BETA1-4)-2-ACETAMIDO-1,6-ANHYDRO-3-O-[(R)-1-CARBOXYETHYL]-2-DEOXY-BETA-D-GLUCOPYRANOSE-L-ALANYL-GAMMA-D-GLUTAMYL-MESO-DIAMINOPIMELYL-D-ALANINE
Diseases
GWAS		Asthma ( 31619474) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189)	Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)
Interacting Genes		4 interacting genes: CIDEB FAM209A HSD17B14 KRT34	24 interacting genes: AKIRIN2 BRIP1 CA8 CDKN2D CYTOR DDIT3 INCA1 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 OTUD3 PGLYRP3 PHF1 PICK1 PIDD1 PSMA1 REL SNAPC3 SNRPC SREK1IP1 TBC1D22B
Entrez ID		114771	51171
HPRD ID		16297	16801
Ensembl ID		ENSG00000159527	ENSG00000087076
Uniprot IDs		Q96LB9	A0A140VJH8 Q9BPX1
PDB IDs		1SK3 1SK4 1TWQ 2APH	1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO 6QCK 6ZDE 6ZDI 6ZR6 6ZRA 6ZT2
Enriched GO Terms of Interacting Partners?		D-threo-aldose 1-dehydrogenase Activity COPI-coated Vesicle COPII Vesicle Coat Lipid Transfer Activity Lipid Droplet Fusion Very-low-density Lipoprotein Particle Assembly Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity L-fucose Catabolic Process Fucose Metabolic Process COPII-coated Vesicle Cargo Loading Execution Phase Of Apoptosis Phosphatidic Acid Binding Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly
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