PGLYRP3 and CIDEB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PGLYRP3	CIDEB
Description		peptidoglycan recognition protein 3	cell death inducing DFFA like effector b
Image
GO Annotations	Cellular Component	Extracellular Region Membrane Protein-containing Complex	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Cytosol Membrane COPII Vesicle Coat COPI-coated Vesicle Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Zinc Ion Binding N-acetylmuramoyl-L-alanine Amidase Activity Peptidoglycan Immune Receptor Activity Peptidoglycan Binding Protein Heterodimerization Activity	Protein Binding Identical Protein Binding Molecular Adaptor Activity Phosphatidic Acid Binding Lipid Transfer Activity
	Biological Process	Immune System Process Immune Response Peptidoglycan Catabolic Process Detection Of Bacterium Killing Of Cells Of Another Organism Negative Regulation Of Type II Interferon Production Negative Regulation Of Natural Killer Cell Differentiation Involved In Immune Response Defense Response To Bacterium Innate Immune Response Defense Response To Gram-positive Bacterium Biological Process Involved In Interaction With Host Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide	Apoptotic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Lipid Storage Response To Nutrient Levels Very-low-density Lipoprotein Particle Assembly Positive Regulation Of Apoptotic Process COPII-coated Vesicle Cargo Loading Regulation Of Triglyceride Metabolic Process Execution Phase Of Apoptosis Intermembrane Lipid Transfer Lipid Droplet Fusion
Pathways		Antimicrobial peptides
Drugs		2-ACETAMIDO-2-DEOXY-BETA-D-GLUCOPYRANOSE(BETA1-4)-2-ACETAMIDO-1,6-ANHYDRO-3-O-[(R)-1-CARBOXYETHYL]-2-DEOXY-BETA-D-GLUCOPYRANOSE-L-ALANYL-GAMMA-D-GLUTAMYL-MESO-DIAMINOPIMELYL-D-ALANINE
Diseases
GWAS		Asthma ( 31619474) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189)	Anorectal malformation ( 31136621) Height ( 28552196) Parent of origin effect on language impairment (paternal) ( 24571439)
Interacting Genes		4 interacting genes: CIDEB FAM209A HSD17B14 KRT34	68 interacting genes: ABHD16A AFG1L APOC1 ARL8B ATP5ME ATP5MJ BCL2L2 CAND2 CIDEA CLCN1 CMPK1 COL10A1 COL8A1 COX7C DFFA DFFB DHRSX DNAJA3 FAM218A FAM47E-STBD1 FKBP8 FOXD4L3 FUNDC2 GCSH GNB3 GPAM H4C7 HAPLN2 HCCS HIGD1C IRX2-DT MEST MICOS10 MPC2 MRPL36 MRPL57 MTERF4 NAALAD2 NDRG4 NFU1 NME4 PBX3 PDHX PGLYRP3 PISD PPIF RAMP2 RHBDD2 ROMO1 RTP5 SAA2 SAA4 SAR1B SCO1 SCO2 SDHAF1 SFXN1 SMARCC1 SPG21 TAOK2 TBX2 TEX44 THBD TIMM17B TMEM14B TPRG1 TSR1 UFSP1
Entrez ID		114771	27141
HPRD ID		16297	11981
Ensembl ID		ENSG00000159527	ENSG00000136305
Uniprot IDs		Q96LB9	Q9UHD4
PDB IDs		1SK3 1SK4 1TWQ 2APH	1D4B
Enriched GO Terms of Interacting Partners?		D-threo-aldose 1-dehydrogenase Activity COPI-coated Vesicle COPII Vesicle Coat Lipid Transfer Activity Lipid Droplet Fusion Very-low-density Lipoprotein Particle Assembly Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity L-fucose Catabolic Process Fucose Metabolic Process COPII-coated Vesicle Cargo Loading Execution Phase Of Apoptosis Phosphatidic Acid Binding Protein-lipid Complex Assembly Plasma Lipoprotein Particle Assembly	Mitochondrion Mitochondrial Inner Membrane Regulation Of Apoptotic DNA Fragmentation Negative Regulation Of Apoptotic DNA Fragmentation High-density Lipoprotein Particle Protein Binding Mitochondrion Organization Mitochondrial Membrane Copper Chaperone Activity Disordered Domain Specific Binding T Cell Apoptotic Process Mitochondrial Matrix Organophosphate Biosynthetic Process Cytochrome Complex Assembly Pyruvate Decarboxylation To Acetyl-CoA Activation-induced Cell Death Of T Cells Mitochondrial Respiratory Chain Complex Assembly Lymphocyte Apoptotic Process Import Into The Mitochondrion Negative Regulation Of Execution Phase Of Apoptosis Protein Localization To Mitochondrion
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