CTRC and NEDD8

Number of citations of the paper that reports this interaction (PMID 16979187)
6

Data Source:
BioGRID (enzymatic study)

		CTRC	NEDD8
Gene Name		chymotrypsin C (caldecrin)	neural precursor cell expressed, developmentally down-regulated 8
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Gene Ontology Annotations	Cellular Component		Nucleus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Proteolysis	Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Neddylation
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: KRTAP10-3 KRTAP10-7 NEDD8 PHKG1 SERPINA3 SPINK1 ST13 UBC	34 interactors: AHR ANK1 ARIH1 ARIH2 CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B CUL5 DCUN1D1 DNMT3B NAE1 NPLOC4 NUB1 PARP1 PSMD4 PTK2 RPL11 SENP8 SMURF1 TP53 UBA2 UBA3 UBE2F UBE2K UBE2M UBXN7 UCHL1 UCHL3 UFD1L
Entrez ID		11330	4738
HPRD ID		03242	04412
Ensembl ID		ENSG00000162438	ENSG00000129559
Uniprot IDs		Q99895	Q15843
PDB IDs		4H4F	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP
Enriched GO Terms of Interacting Partners?		Glycogen Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Cellular Polysaccharide Biosynthetic Process Polysaccharide Biosynthetic Process Glycogen Metabolic Process Polysaccharide Metabolic Process Regulation Of Proteolysis Energy Reserve Metabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Glucose Metabolic Process Carbohydrate Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Catalytic Activity Negative Regulation Of Nitric Oxide Mediated Signal Transduction Negative Regulation Of Cellular Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Regulation Of Protein Metabolic Process Response To Transforming Growth Factor Beta Negative Regulation Of Protein Refolding Pathogenesis Hexose Metabolic Process Negative Regulation Of Calcium Ion Import Chaperone Cofactor-dependent Protein Refolding Cellular Carbohydrate Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Monosaccharide Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Energy Derivation By Oxidation Of Organic Compounds Negative Regulation Of Serine-type Endopeptidase Activity Protein Neddylation Negative Regulation Of Serine-type Peptidase Activity Regulation Of Acrosome Reaction Viral Protein Processing Negative Regulation Of Proteolysis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Generation Of Precursor Metabolites And Energy Regulation Of Store-operated Calcium Entry Glycogen Catabolic Process Protein Refolding Epithelial Structure Maintenance Polysaccharide Catabolic Process Regulation Of Calcium Ion Import Notch Receptor Processing	Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Modification By Small Protein Conjugation Cellular Macromolecule Catabolic Process Proteolysis Cellular Protein Metabolic Process Protein Metabolic Process Cellular Protein Modification Process Protein Ubiquitination Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Neddylation Cellular Metabolic Process G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Intrinsic Apoptotic Signaling Pathway Regulation Of Cell Cycle Metabolic Process Positive Regulation Of Protein Catabolic Process Protein Deneddylation Apoptotic Process Mitotic Cell Cycle Programmed Cell Death Regulation Of Protein Catabolic Process Cell Death Death Cell Cycle Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Cell Cycle Arrest Negative Regulation Of Cell Cycle Mitotic Cell Cycle Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Apoptotic Signaling Pathway Viral Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K48-linked Ubiquitination Protein Modification By Small Protein Removal Protein Monoubiquitination Positive Regulation Of Proteolysis
Tagcloud ?		a73t acinar acini adenovirus ar42j became bip carrying characterised chop chymotrypsinogen considerably destruction detached dexamethasone ebp elicit exocrine freshly immunoglobulin judged mediator pancreas pancreatitis parenchymal permanent propensity tunel xbp1	activate activates activating analyze app appbp1 covalently cullin discuss downregulates driven existing gradual gradually hypothesize insights integrity investigation ligases lost modifies neddylation precursor protects reverse slow switches turnover ubiquitin
Tagcloud (Difference) ?		a73t acinar acini adenovirus ar42j became bip carrying characterised chop chymotrypsinogen considerably destruction detached dexamethasone ebp elicit exocrine freshly immunoglobulin judged mediator pancreas pancreatitis parenchymal permanent propensity tunel xbp1	activate activates activating analyze app appbp1 covalently cullin discuss downregulates driven existing gradual gradually hypothesize insights integrity investigation ligases lost modifies neddylation precursor protects reverse slow switches turnover ubiquitin
Tagcloud (Intersection) ?