Wiki-Pi
About
Search
People
Updates
Search
VSIG4 and POLE
VSIG4
POLE
Description
V-set and immunoglobulin domain containing 4
DNA polymerase epsilon, catalytic subunit
Image
GO Annotations
Cellular Component
Membrane
Protein-containing Complex
Nucleus
Nucleoplasm
Plasma Membrane
Epsilon DNA Polymerase Complex
Molecular Function
Complement Component C3b Binding
Protein Binding
Nucleotide Binding
Nucleic Acid Binding
DNA Binding
Chromatin Binding
DNA-directed DNA Polymerase Activity
Protein Binding
Zinc Ion Binding
Single-stranded DNA 3'-5' DNA Exonuclease Activity
Transferase Activity
Nucleotidyltransferase Activity
Hydrolase Activity
DNA Polymerase Activity
Metal Ion Binding
Iron-sulfur Cluster Binding
4 Iron, 4 Sulfur Cluster Binding
Biological Process
Immune System Process
Complement Activation, Alternative Pathway
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of T Cell Proliferation
Negative Regulation Of Macrophage Activation
Innate Immune Response
Negative Regulation Of Complement Activation, Alternative Pathway
G1/S Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
DNA Synthesis Involved In DNA Repair
DNA Replication
DNA-templated DNA Replication
Leading Strand Elongation
DNA Repair
Base-excision Repair, Gap-filling
Nucleotide-excision Repair, DNA Gap Filling
DNA Damage Response
DNA Replication Proofreading
Embryonic Organ Development
DNA Biosynthetic Process
Pathways
Recognition of DNA damage by PCNA-containing replication complex
PCNA-Dependent Long Patch Base Excision Repair
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
DNA replication initiation
Activation of the pre-replicative complex
Drugs
Cladribine
Diseases
GWAS
Male-pattern baldness (
28196072
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Body mass index (
26426971
)
Metabolite levels (
23823483
)
Urate levels in overweight individuals (
25811787
)
Interacting Genes
7 interacting genes:
APP
C3
FATE1
JAGN1
PDK2
TRIM72
VAMP5
13 interacting genes:
ABHD16A
CFTR
CLSPN
GINS4
MDM2
PCNA
POLA1
POLD4
POLE4
RAD17
TOPBP1
WHR1
XRCC5
Entrez ID
11326
5426
HPRD ID
02286
07177
Ensembl ID
ENSG00000155659
ENSG00000177084
Uniprot IDs
Q9Y279
Q07864
PDB IDs
2ICC
2ICE
2ICF
5IMK
5IML
8TE5
8TE6
5VBN
7PFO
7PLO
9B8S
9B8T
9F6D
9F6E
9F6F
9F6I
9F6J
9F6K
9F6L
Enriched GO Terms of Interacting Partners
?
Neuron Remodeling
Positive Regulation Of Endocytosis
Secretion By Cell
Secretion
Vesicle-mediated Transport
Clathrin-coated Pit
Signal Sequence Binding
Regulation Of Endocytosis
Regulation Of Vesicle-mediated Transport
Extrinsic Component Of Presynaptic Endocytic Zone Membrane
Acetylcholine Receptor Activator Activity
Amyloid-beta Complex
PTB Domain Binding
Regulation Of Phosphorus Metabolic Process
Monoatomic Ion Homeostasis
Growth Cone Lamellipodium
Collateral Sprouting In Absence Of Injury
Regulation Of Protein Import
Response To Norepinephrine
Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Intermediate-density Lipoprotein Particle
Regulation Of Response To Calcium Ion
Axon Midline Choice Point Recognition
Positive Regulation Of G Protein-coupled Receptor Signaling Pathway
Response To Stress
Amylin Binding
Endosome To Plasma Membrane Transport Vesicle
Neuron Maturation
Positive Regulation Of Amyloid Fibril Formation
Positive Regulation Of Toll Signaling Pathway
Positive Regulation Of Endothelin Production
Growth Cone Filopodium
Cellular Response To Norepinephrine Stimulus
Regulation Of Receptor-mediated Endocytosis
Receptor Ligand Activity
Positive Regulation Of Receptor-mediated Endocytosis
Monoatomic Cation Homeostasis
Defense Response To Fungus
Response To Fungus
Regulation Of Calcium-mediated Signaling
Lipoprotein Particle
Growth Factor Receptor Binding
Main Axon
Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Protein Import
Response To Other Organism
Astrocyte Activation Involved In Immune Response
Microglia Development
Positive Regulation Of G Protein-coupled Receptor Internalization
Immune Effector Process
DNA Metabolic Process
DNA Repair
Response To Stress
DNA Damage Response
Cellular Response To Stress
DNA Biosynthetic Process
Mitotic DNA Replication Checkpoint Signaling
DNA-templated DNA Replication
DNA Replication
DNA Replication Checkpoint Signaling
DNA-directed DNA Polymerase Activity
Nucleic Acid Metabolic Process
Leading Strand Elongation
DNA Synthesis Involved In DNA Repair
Macromolecule Metabolic Process
Signal Transduction In Response To DNA Damage
Male Germ Cell Nucleus
Mitotic G2/M Transition Checkpoint
Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair Via Nonhomologous End Joining
Mitotic DNA Damage Checkpoint Signaling
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Mitotic DNA Integrity Checkpoint Signaling
Negative Regulation Of Cell Cycle G2/M Phase Transition
DNA Strand Elongation Involved In DNA Replication
Double-strand Break Repair
Protein-containing Complex
Chromatin-protein Adaptor Activity
DNA Damage Checkpoint Signaling
Response To Lipid
DNA Strand Elongation
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Localization To Chromosome
Regulation Of Cell Cycle G2/M Phase Transition
Nucleoplasm
Protein Localization To Site Of Double-strand Break
DNA Replication Initiation
Cellular Response To Gamma Radiation
Recycling Endosome
Regulation Of Mitotic Cell Cycle Phase Transition
Recombinational Repair
Response To Hormone
Response To Ionizing Radiation
Chromosome Organization
Protein-containing Complex Binding
Protein Localization To Organelle
Mitotic G2 DNA Damage Checkpoint Signaling
Negative Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Sphingolipid Mediated Signaling Pathway
High-density Lipoprotein Particle Receptor Activity
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?