VSIG4 and PDK2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		VSIG4	PDK2
Gene Name		V-set and immunoglobulin domain containing 4	pyruvate dehydrogenase kinase, isozyme 2
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane Extracellular Vesicular Exosome	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex
	Molecular Function	Protein Binding	Protein Kinase Activity Pyruvate Dehydrogenase (acetyl-transferring) Kinase Activity ATP Binding Protein Homodimerization Activity
	Biological Process	Complement Activation, Alternative Pathway Negative Regulation Of Interleukin-2 Production Negative Regulation Of T Cell Proliferation	Glucose Metabolic Process Pyruvate Metabolic Process Regulation Of Gluconeogenesis Protein Phosphorylation Regulation Of PH Insulin Receptor Signaling Pathway Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Cellular Ketone Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Nutrient Cellular Response To Reactive Oxygen Species Glucose Homeostasis Cellular Metabolic Process Small Molecule Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways			Regulation of pyruvate dehydrogenase (PDH) complex Pyruvate metabolism Signaling by Retinoic Acid Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: APP C3 PDK2	10 interactors: AKT1 DLAT HIC2 HTT ISOC2 PDHA1 PDHX PDK1 SGK1 VSIG4
Entrez ID		11326	5164
HPRD ID		02286	03955
Ensembl ID		ENSG00000155659	ENSG00000005882
Uniprot IDs		Q9Y279	B4DLP2 Q15119
PDB IDs		2ICC 2ICE 2ICF	2BTZ 2BU2 2BU5 2BU6 2BU7 2BU8
Enriched GO Terms of Interacting Partners?		Synaptic Growth At Neuromuscular Junction Positive Regulation Of Type IIa Hypersensitivity Regulation Of Phosphorus Metabolic Process Collateral Sprouting In Absence Of Injury Negative Regulation Of Endopeptidase Activity Negative Regulation Of Peptidase Activity Regulation Of Lipid Metabolic Process Positive Regulation Of Activation Of Membrane Attack Complex Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Processing Regulation Of Endopeptidase Activity Axon Choice Point Recognition Positive Regulation Of Hypersensitivity Negative Regulation Of Hydrolase Activity Regulation Of Protein Processing Regulation Of Peptidase Activity Positive Regulation Of Apoptotic Cell Clearance Response To Oxidative Stress Small Molecule Metabolic Process Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Neuron Remodeling Regulation Of Cellular Ketone Metabolic Process Regulation Of Apoptotic Cell Clearance Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Acyl-CoA Biosynthetic Process Ion Homeostasis Monocarboxylic Acid Metabolic Process Positive Regulation Of Humoral Immune Response Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Copper Ion Homeostasis Regulation Of Proteolysis Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process Copper Ion Homeostasis Suckling Behavior Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Response To Stress Negative Regulation Of Catalytic Activity Positive Regulation Of Acute Inflammatory Response Innate Immune Response Negative Regulation Of Cellular Protein Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity	Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Regulation Of Acyl-CoA Biosynthetic Process Regulation Of Fatty Acid Metabolic Process Pyruvate Metabolic Process Regulation Of Lipid Metabolic Process Glucose Metabolic Process Regulation Of Cellular Ketone Metabolic Process Hexose Metabolic Process Monocarboxylic Acid Metabolic Process Monosaccharide Metabolic Process Regulation Of Phosphorus Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Protein Localization To Plasma Membrane Organic Acid Metabolic Process Response To Epidermal Growth Factor Positive Regulation Of Ion Transport Small Molecule Metabolic Process Regulation Of Establishment Of Protein Localization To Plasma Membrane Tricarboxylic Acid Cycle Positive Regulation Of Transport Citrate Metabolic Process Response To Hypoxia Regulation Of T Cell Activation Regulation Of Protein Localization To Plasma Membrane Energy Derivation By Oxidation Of Organic Compounds Regulation Of Metabolic Process Endocrine Pancreas Development Tricarboxylic Acid Metabolic Process Positive Regulation Of Transporter Activity Aerobic Respiration Regulation Of Cell-cell Adhesion Neural Plate Formation Glycogen Cell Differentiation Involved In Embryonic Placenta Development T Cell Costimulation Apoptotic Process Regulation Of Lymphocyte Activation Programmed Cell Death Generation Of Precursor Metabolites And Energy Carbohydrate Metabolic Process Cell Death Death Positive Regulation Of Calcium Ion Transport Pancreas Development Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Regulation Of Cell Activation
Tagcloud ?		293ft absent b7 cd3 cd31 cd68 cd8 ck cocultured coexpressed efficacious facilitates grown h1 immunofluorescent immunohistochemically infiltration lewis littermates lung macrophage macrophages massive prominent prove smaller stroma transfection	addressed adenovirus aerobic biosynthetic dehydrogenase deprivation glutamine glycolysis gsh gssg hep3b hepatology hepatoma hepg2 metabolism mimic nadp nadph orphan pdhe1alpha pyruvate reprogramming restricting ror roralpha shifted sr1078 supply xenograft
Tagcloud (Difference) ?		293ft absent b7 cd3 cd31 cd68 cd8 ck cocultured coexpressed efficacious facilitates grown h1 immunofluorescent immunohistochemically infiltration lewis littermates lung macrophage macrophages massive prominent prove smaller stroma transfection	addressed adenovirus aerobic biosynthetic dehydrogenase deprivation glutamine glycolysis gsh gssg hep3b hepatology hepatoma hepg2 metabolism mimic nadp nadph orphan pdhe1alpha pyruvate reprogramming restricting ror roralpha shifted sr1078 supply xenograft
Tagcloud (Intersection) ?