PPP1R9B and SHANK3

Number of citations of the paper that reports this interaction (PubMedID 21653829)
54

Data Source:
BioGRID (two hybrid)

		PPP1R9B	SHANK3
Description		protein phosphatase 1 regulatory subunit 9B	SH3 and multiple ankyrin repeat domains 3
Image		No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 1 Complex Nucleus Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Adherens Junction Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Filopodium Dendrite Growth Cone Cortical Actin Cytoskeleton Ruffle Membrane Dendritic Spine Membrane Cell Projection Neuronal Cell Body Dendritic Spine Dendritic Spine Neck Dendritic Spine Head Synapse Anchoring Junction Spine Apparatus Extrinsic Component Of Postsynaptic Membrane Glutamatergic Synapse Plasma Membrane Bounded Cell Projection Cytoplasmic Side Of Dendritic Spine Plasma Membrane	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Cell Projection Neuron Projection Dendritic Spine Neuron Spine Synapse Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Actin Binding Protein Kinase Activity Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding Kinase Binding D2 Dopamine Receptor Binding Transmembrane Transporter Binding Protein-containing Complex Binding Actin Filament Binding	Actin Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding Scaffold Protein Binding
	Biological Process	Regulation Of Cell Growth By Extracellular Stimulus Response To Amphetamine Developmental Process Involved In Reproduction Actin Filament Organization Regulation Of Exit From Mitosis Nervous System Development Learning RNA Splicing Response To Xenobiotic Stimulus Dendrite Development Cell Migration Calcium-mediated Signaling Hippocampus Development Cerebral Cortex Development Actin Filament Depolymerization Cell Differentiation Negative Regulation Of Cell Growth Neuron Projection Development Response To Estradiol Response To Prostaglandin E Response To Nicotine Response To Immobilization Stress Regulation Of Cell Population Proliferation Response To Amino Acid Filopodium Assembly Response To Steroid Hormone Regulation Of Cell Cycle Male Mating Behavior Reproductive System Development Cellular Response To Morphine Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Xenobiotic Stimulus Regulation Of Postsynapse Assembly Cellular Response To Peptide Positive Regulation Of Protein Localization To Plasma Membrane Protein Localization To Actin Cytoskeleton Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Actin Cortical Patch Response To Kainic Acid Response To L-phenylalanine Derivative Protein Localization To Cell Periphery Regulation Of Opioid Receptor Signaling Pathway	MAPK Cascade Synapse Assembly Learning Memory Associative Learning Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Synapse Organization Neuromuscular Process Controlling Balance Cognition Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Positive Regulation Of Excitatory Postsynaptic Potential
Pathways			Neurexins and neuroligins Neurexins and neuroligins RET signaling
Drugs
Diseases
GWAS		Platelet distribution width ( 32888494) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 26561523 28107422) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Platelet count ( 32888494)
Interacting Genes		29 interacting genes: ACTA1 ACTN2 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C CCKAR CCKBR CDKN2A CHRM3 DCX DRD2 ITGB8 LRRC7 MAPK1 MECOM PPP1CA PPP1R2 PPP1R9A PRKACA RB1 RBL1 RBL2 RGS2 RPS6KB1 SHANK3 TGOLN2 TIAM1	152 interacting genes: ABCC2 ABI1 ABI2 ACE2 ACTN2 ADGRL1 AGAP7P ALDOA ANKRD35 APP ARHGAP44 ARPC2 ARPC5L ATN1 BAIAP2 C1QBP CA10 CALCOCO1 CAMK2B CCT3 CEP72 CIBAR1 CLTA CLU CNKSR2 COPS5 COPS6 COQ5 CPAP CRELD1 CRKL CSNK1D CTTN CYP51A1 CYTIP DBNL DCTN2 DDB1 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJA3 DNM2 EFEMP1 EFEMP2 EID1 ELAVL1 ERI3 FAM13A FBXO7 FKBP8 FRS3 FRYL GAPDH GOT1 GPR162 GRB2 GRN HAGH HECW1 HGS HNRNPK HOMER3 ICA1 IGSF9 ITGBL1 ITSN1 JAG2 KHDRBS1 KIAA0232 LINGO1 LRRC73 LTBP3 LTBP4 LZTS2 LZTS3 MAPK1 MBIP MBOAT7 MCRS1 MDH2 MEGF10 MEGF11 MEGF6 MIPOL1 MRM3 MT-CO2 MT-ND6 MYO5B N4BP3 NCK1 NCKIPSD NEFL NGRN NOTCH1 NOTCH2 NOTCH2NLA NOTCH3 NR1D1 NRBF2 PAX6 PFKL PHF12 PHLDB1 PLEKHA4 PPHLN1 PPP1CC PPP1R13L PPP1R9B PPP2R3B PRMT2 QSOX1 RBM5 RPS6KA1 RTN3 RUNDC3A SCYL3 SETD2 SH3GL2 SH3GL3 SHANK1 SHARPIN SIPA1 SLC48A1 SNRPN SORBS2 SORBS3 SPAG5 SPTAN1 SRSF9 STK32C SYNGAP1 SYT5 TCF25 TDRD7 TFIP11 THRAP3 TMEM14C TNIP2 TRAF3 TRIM27 TRIM9 TRIP10 TSG101 TUBA1C UCHL1 USP8 VIM VPS18 WWP1 ZCCHC2
Entrez ID		84687	85358
HPRD ID		04506	18979
Ensembl ID		ENSG00000108819	ENSG00000251322
Uniprot IDs		Q96SB3	Q9BYB0
PDB IDs			6CPK 7C7I 7C7J
Enriched GO Terms of Interacting Partners?		Adrenergic Receptor Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adrenergic Receptor Signaling Pathway Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Negative Regulation Of Catecholamine Secretion Alpha2-adrenergic Receptor Activity Regulation Of Muscle System Process Intracellular Signaling Cassette Regulation Of Blood Circulation G Protein-coupled Receptor Activity Signal Transduction Regulation Of System Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Lipid Kinase Activity Intracellular Signal Transduction Negative Regulation Of Epinephrine Secretion Regulation Of Vasoconstriction Negative Regulation Of Norepinephrine Secretion Epinephrine Binding Regulation Of Amine Transport System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Catecholamine Secretion Regulation Of Biological Quality Regulation Of MAPK Cascade Regulation Of Signal Transduction Regulation Of Norepinephrine Secretion Modulation Of Chemical Synaptic Transmission Positive Regulation Of Muscle Contraction Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Developmental Process Phospholipase C-activating Adrenergic Receptor Signaling Pathway Cholecystokinin Receptor Activity Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Hormone Secretion Dendritic Spine Positive Regulation Of Signal Transduction Regulation Of Tube Size Blood Vessel Diameter Maintenance Regulation Of Intracellular Signal Transduction Alpha1-adrenergic Receptor Activity Cholecystokinin Signaling Pathway Regulation Of Insulin Secretion ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization	Synapse Glutamatergic Synapse Postsynaptic Density Protein Domain Specific Binding Cytoplasm Dendritic Spine Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Supramolecular Fiber Organization Organelle Organization Identical Protein Binding Regulation Of Cellular Component Organization Endocytosis Cytoskeleton Regulation Of Signal Transduction Cytoskeleton Organization SH3 Domain Binding Positive Regulation Of Cytoskeleton Organization Cytosol Cell Projection Morphogenesis Regulation Of Supramolecular Fiber Organization Supramolecular Fiber Organization Postsynaptic Specialization Neuron Projection Signal Transduction Dendrite Development Endosome Cell Projection Organization Regulation Of Actin Filament Organization Cell Projection Neuron Projection Morphogenesis Regulation Of Postsynapse Organization Positive Regulation Of Cellular Component Organization Positive Regulation Of Amyloid Fibril Formation Notch Signaling Pathway Lamellipodium Modulation Of Chemical Synaptic Transmission Plasma Membrane Bounded Cell Projection Organization Import Into Cell Vesicle-mediated Transport Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Organelle Organization Regulation Of Synapse Organization Regulation Of Cytoskeleton Organization Actin Filament Organization Neuron Projection Development Cadherin Binding Modification Of Postsynaptic Structure Regulation Of Cell Projection Organization Postsynaptic Cytoskeleton Organization
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