ADCY7 and PLSCR1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ADCY7	PLSCR1
Description		adenylate cyclase 7	phospholipid scramblase 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Adenylate Cyclase Activity ATP Binding Lyase Activity Phosphorus-oxygen Lyase Activity Metal Ion Binding	Magnesium Ion Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Virus Receptor Activity DNA Binding Nuclease Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Hydrolase Activity SH3 Domain Binding Phospholipid Scramblase Activity Enzyme Binding Lead Ion Binding CD4 Receptor Binding Mercury Ion Binding
	Biological Process	Regulation Of Adaptive Immune Response CAMP Biosynthetic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cyclic Nucleotide Biosynthetic Process Intracellular Signal Transduction Maternal Process Involved In Female Pregnancy Cellular Response To Lithium Ion Cellular Response To Ethanol Negative Regulation Of Cytokine Production Involved In Inflammatory Response	Phosphatidylserine Biosynthetic Process Lipid Transport Apoptotic Process Acute-phase Response Response To Lead Ion Positive Regulation Of Gene Expression Plasma Membrane Phospholipid Scrambling Platelet Activation Regulation Of Mast Cell Activation Response To Interferon-beta Negative Regulation Of Viral Genome Replication Positive Regulation Of Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Negative Regulation Of Phagocytosis Defense Response To Virus Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of Chromosome Separation Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Pathways		Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state GPER1 signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Drugs		Colforsin
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Crohn's disease ( 23128233) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688) Ulcerative colitis ( 28067908 28067910)	Gut microbiota (beta diversity) ( 27723756)
Interacting Genes		4 interacting genes: BUD31 PLSCR1 PRKCD XRCC6	132 interacting genes: ABL1 ADAMTSL4 ADCY7 ANXA11 APP ARNT2 ATG12 ATN1 BACE1 BCL6B C10orf62 CATSPER1 CCDC33 CCER1 CDC42EP1 CHRD CNTFR CPSF6 CRK CRKL CRY1 CTBP1-DT CTSZ DAZAP2 DDIAS DEF6 DEPP1 DHRS1 DLK2 DMRT3 DOCK2 DTX2 EFEMP2 EGFR ENKD1 EP300 ESR2 EWSR1 EXD3 FAM107A FBLN1 FBXL18 FRAT1 FRS3 GDPD5 GLRX3 GNAI2 GPRIN2 HEY2 HOXA1 HOXA9 HOXB6 HRG ILF3 INTS11 IP6K2 IQCN KIF1A KRTAP10-11 KRTAP10-3 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 LASP1 LCE2D LCE3C LCE4A LGALS9C LINC00663 LINC01547 LONRF1 MAPK6 MDK MED15 MGAT5B MVP NECAP2 NEU4 NOC4L NPDC1 NR0B2 NTN4 OGDH P2RY6 PCED1A PGLS PHLDA1 PITX1 PKD2 PLSCR3 PLSCR4 PML PPDPF PRKCD PRR13 RAMAC RASD1 RBL1 RERE RGS3 RXRB SCNM1 SF1 SHC1 SLC25A6 SLC35A2 SLPI SMARCC1 SMCP SPATA8 SPG7 SPRY2 SRC STK16 TFG THBS1 TRAF4 TRIM42 VASP VPS37C VSIR YIPF3 ZBTB16 ZNF417 ZNF581 ZNF587 ZNF638 ZNF688 ZNF764
Entrez ID		113	5359
HPRD ID		02663	08855
Ensembl ID		ENSG00000121281	ENSG00000188313
Uniprot IDs		B3KSJ0 F5H4D1 P51828 Q86YI0	C9J7K9 O15162
PDB IDs			1Y2A
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Catalytic Activity Positive Regulation Of Immune Response Positive Regulation Of Biosynthetic Process Regulation Of Immune Response DNA End Binding Regulation Of Defense Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Catalytic Activity Cellular Response To Radiation Ku70:Ku80 Complex Regulation Of Cell Activation Phosphatidylserine Biosynthetic Process Mercury Ion Binding Lead Ion Binding Phosphatidylserine Exposure On Apoptotic Cell Surface Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Positive Regulation Of Phospholipid Scramblase Activity Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Phospholipid Catabolic Process Positive Regulation Of Glucosylceramide Catabolic Process Positive Regulation Of Sphingomyelin Catabolic Process Positive Regulation Of Endodeoxyribonuclease Activity Termination Of Signal Transduction Positive Regulation Of Immune System Process Negative Regulation Of Filopodium Assembly Diacylglycerol-dependent, Calcium-independent Serine/threonine Kinase Activity Positive Regulation Of Deoxyribonuclease Activity Protein Kinase C Signaling Response To Other Organism Positive Regulation Of Macromolecule Metabolic Process Cellular Hyperosmotic Salinity Response DNA-dependent Protein Kinase Complex Positive Regulation Of Metabolic Process Hyperosmotic Salinity Response Defense Response Nuclear Telomere Cap Complex Positive Regulation Of Phosphate Metabolic Process DNA-dependent Protein Kinase-DNA Ligase 4 Complex Regulation Of RNA Metabolic Process Response To External Biotic Stimulus 5'-deoxyribose-5-phosphate Lyase Activity Positive Regulation Of Innate Immune Response Cellular Response To Chemical Stress Double-stranded Telomeric DNA Binding Nonhomologous End Joining Complex CD4 Receptor Binding Phospholipase C/protein Kinase C Signal Transduction Cellular Response To Hydroperoxide Positive Regulation Of Ceramide Biosynthetic Process Regulation Of Endodeoxyribonuclease Activity	Enzyme Binding Ephrin Receptor Binding Protein Binding Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell-substrate Adhesion Cellular Response To Transforming Growth Factor Beta Stimulus Keratin Filament Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Response To Transforming Growth Factor Beta Intermediate Filament Response To Growth Factor Regulation Of Cell Adhesion Positive Regulation Of MAPK Cascade Helper T Cell Diapedesis Shc-EGFR Complex Positive Regulation Of Cell-substrate Adhesion Regulation Of Superoxide Metabolic Process Negative Regulation Of Long-term Synaptic Potentiation Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Cell Adhesion Positive Regulation Of Cell Adhesion Response To Lipid Hair Cycle Apoptotic Process Regulation Of Focal Adhesion Assembly Regulation Of MAPK Cascade Cerebellar Neuron Development Regulation Of Apoptotic Process Protein Tyrosine Kinase Activator Activity Cellular Response To Lipid Morphogenesis Of A Branching Structure ERBB Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of Cell-substrate Junction Organization Gland Development Regulation Of RNA Biosynthetic Process Programmed Cell Death Cell Death Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Non-membrane Spanning Protein Tyrosine Kinase Activity Epidermal Growth Factor Binding System Development Regulation Of Cell Population Proliferation Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Migration Regulation Of Programmed Cell Death Regulation Of Cell-matrix Adhesion Positive Regulation Of Superoxide Anion Generation Central Nervous System Neuron Development
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