STX1B and UNC13B

Number of citations of the paper that reports this interaction (PMID 8999968)
59

Data Source:
BioGRID (two hybrid, biochemical)

		STX1B	UNC13B
Gene Name		syntaxin 1B	unc-13 homolog B (C. elegans)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Microtubule Organizing Center Spindle Cytosol Plasma Membrane Synaptic Vesicle Endomembrane System Membrane Integral Component Of Membrane SNARE Complex	Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cell Junction Neuromuscular Junction Terminal Bouton Presynaptic Active Zone
	Molecular Function	SNARE Binding SNAP Receptor Activity Protein Kinase Binding Protein Domain Specific Binding	Signal Transducer Activity Receptor Activity Protein Binding Diacylglycerol Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Intracellular Protein Transport Pathogenesis Regulation Of Gene Expression Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Fusion To Presynaptic Membrane Vesicle Docking Positive Regulation Of Excitatory Postsynaptic Membrane Potential	Apoptotic Process Signal Transduction Synaptic Transmission Neurotransmitter Secretion Neuromuscular Junction Development Excretion Positive Regulation Of Synaptic Vesicle Priming Glutamate Secretion Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Transmission, Glutamatergic Intracellular Signal Transduction Regulation Of Short-term Neuronal Synaptic Plasticity Innervation Positive Regulation Of Inhibitory Postsynaptic Membrane Potential
Pathways		Uptake and actions of bacterial toxins Toxicity of botulinum toxin type C (BoNT/C) Neurotoxicity of clostridium toxins	Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS			Parkinson's disease ( 21812969)
Protein-Protein Interactions		5 interactors: SNAP23 STXBP1 UNC13B VAMP1 VAMP2	9 interactors: DOC2A DOC2B RIMS1 RPH3AL SPTBN2 STX1A STX1B STX2 TOE1
Entrez ID		112755	10497
HPRD ID		18126	05785
Ensembl ID		ENSG00000099365	ENSG00000198722
Uniprot IDs		P61266	B1AM27 F8W8M9 O14795 Q4LE73
PDB IDs
Enriched GO Terms of Interacting Partners?		Exocytosis Neurotransmitter Secretion Synaptic Vesicle Transport Secretion By Cell Regulation Of Neurotransmitter Levels Glutamate Secretion Neurotransmitter Transport Secretion Establishment Of Vesicle Localization Vesicle Organization Vesicle Localization Vesicle Fusion Synaptic Vesicle Exocytosis Acid Secretion Establishment Of Organelle Localization Organelle Fusion Dicarboxylic Acid Transport Organelle Localization Vesicle-mediated Transport Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Priming Membrane Fusion Synaptic Transmission Regulation Of Exocytosis Amino Acid Transport Anion Transport Regulation Of Synaptic Plasticity Establishment Of Localization In Cell Membrane Organization Cell-cell Signaling Cellular Localization Protein Complex Assembly Regulation Of Synaptic Vesicle Exocytosis Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Regulation Of Synaptic Vesicle Transport Cellular Protein Complex Assembly Leukocyte Degranulation Regulation Of Vesicle-mediated Transport Regulated Secretory Pathway Organic Anion Transport Positive Regulation Of Exocytosis Vesicle Docking Involved In Exocytosis Regulation Of Neurotransmitter Secretion Vesicle Docking Post-Golgi Vesicle-mediated Transport Membrane Docking Ion Transport Cellular Macromolecular Complex Assembly	Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Synaptic Vesicle Exocytosis Neurotransmitter Transport Secretion By Cell Secretion Synaptic Vesicle Transport Exocytosis Regulation Of Exocytosis Establishment Of Vesicle Localization Vesicle Localization Synaptic Vesicle Fusion To Presynaptic Membrane Regulation Of Secretion Vesicle-mediated Transport Establishment Of Organelle Localization Regulation Of Vesicle-mediated Transport Membrane Fusion Cell-cell Signaling Organelle Localization Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Cellular Localization Establishment Of Localization In Cell Positive Regulation Of Membrane Potential Calcium Ion-dependent Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Synaptic Transmission Vesicle Fusion Cellular Localization Regulation Of Neurotransmitter Secretion Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Postsynaptic Membrane Potential Organelle Fusion Positive Regulation Of Secretion Vesicle Docking Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Calcium Ion-dependent Exocytosis Of Neurotransmitter Membrane Docking Transport Intracellular Protein Transport Membrane Depolarization Protein Localization Positive Regulation Of Neurotransmitter Secretion Glutamate Secretion Cellular Protein Localization Protein Transport Vesicle Organization Establishment Of Protein Localization Intracellular Transport Regulation Of Synaptic Vesicle Exocytosis
Tagcloud ?			accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation ppp1r9b retardation syndrome transcriptome trinucleotide untranslated
Tagcloud (Difference) ?			accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation ppp1r9b retardation syndrome transcriptome trinucleotide untranslated
Tagcloud (Intersection) ?